{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:28:05Z","timestamp":1791221285485,"version":"4.1.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"4546","license":[{"start":{"date-parts":[[2013,11,3]],"date-time":"2013-11-03T00:00:00Z","timestamp":1383436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>QUESTIONS UNDER  STUDY: The aim of this study was to evaluate risk factors and outcome of expanded-criteria  donor (ECD) kidney transplants in patients with low immunological risk.\n        METHODS: We  evaluated graft survival and graft function in 265 recipients with low  immunological risk defined as the absence of pretransplant donor-specific HLA antibodies.\n        RESULTS: A  total of 112 (42%) kidneys derived from ECD and 153 (58%) from standard-criteria  donors (SCDs). Overall, in a multivariate Cox regression, ECD status was the  only significant risk factor for graft failure (hazard ratio [HR] 2.31, 95%  confidence interval [CI] 1.22\u20134.37; p = 0.01). In the SCD group there was an  increased risk for graft failure with increasing recipient age (HR 1.06 per  year, CI 1.01\u20131.10; p = 0.02) and in the ECD group a trend for risk reduction for  recipients treated with tacrolimus (Tac) (HR 0.46, CI 0.20\u20121.06; p = 0.07). One,  three and five-year graft survival of ECD kidneys was significantly better when  recipients were treated with Tac (95%, 88% and 72%, respectively) than when they  were treated without Tac (73%, 65% and 50%, respectively) (p = 0.008). At three  years, ECD kidneys had a lower median estimated creatinine clearance (eCrCl)  than SCD kidneys (37 vs 58 ml\/min, p &lt;0.001). Within the ECD group,  recipients treated with Tac had a higher median eCrCl than those treated  without Tac (41 ml\/min vs 33 ml\/min, p = 0.004). Graft function from one to  three years was preserved in ECD recipients treated with Tac (median change 0.0  ml\/min, p = 0.4) compared with those treated without Tac (median change \u20133.2  ml\/min, p\u00a0=\u00a00.005).\n        CONCLUSION:  Tac-based immunosuppression seems to improve graft survival and to preserve  graft function in ECD kidneys with low immunological risk.<\/jats:p>","DOI":"10.4414\/smw.2013.13883","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T10:27:23Z","timestamp":1404383243000},"page":"w13883","source":"Crossref","is-referenced-by-count":3,"title":["Risk  factors and outcome of expanded-criteria donor kidney transplants in patients  with low immunological risk"],"prefix":"10.57187","volume":"143","author":[{"given":"Claudia","family":"Praehauser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Hirt-Minkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiymet","family":"Saydam Bakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Vogler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2013,11,3]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1778\/2438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1778\/2439","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1778\/2438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:03:42Z","timestamp":1755234222000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,3]]},"references-count":0,"journal-issue":{"issue":"4546","published-online":{"date-parts":[[2013,11,4]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13883","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,3]]}}}