{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:53:32Z","timestamp":1756896812912,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1314","license":[{"start":{"date-parts":[[2014,3,23]],"date-time":"2014-03-23T00:00:00Z","timestamp":1395532800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>In the  1980s, leukaemia clusters were discovered around nuclear fuel reprocessing  plants in Sellafield and Dounreay in the United Kingdom. This raised public  concern about the risk of childhood leukaemia near nuclear power plants (NPPs).  Since then, the topic has been well-studied, but methodological limitations  make results difficult to interpret. Our review aims to: (1.) summarise current  evidence on the relationship between NPPs and risk of childhood leukaemia, with  a focus on the Swiss CANUPIS (Childhood cancer and nuclear power plants in  Switzerland) study; (2.) discuss the limitations of previous research; and (3.)  suggest directions for future research.\n        There are  various reasons that previous studies produced inconclusive results. These include:  inadequate study designs and limited statistical power due to the low  prevalence of exposure (living near a NPP) and outcome (leukaemia); lack of  accurate exposure estimates; limited knowledge of the aetiology of childhood  leukaemia, particularly of vulnerable time windows and latent periods; use of  residential location at time of diagnosis only and lack of data on address  histories; and inability to adjust for potential confounders.\n        We  conclude that risk of childhood leukaemia around NPPs should continue to be monitored  and that study designs should be improved and standardised. Data should be  pooled internationally to increase the statistical power. More research needs  to be done on other putative risk factors for childhood cancer such as low-dose  ionizing radiation, exposure to certain chemicals and exposure to infections. Studies  should be designed to allow examining multiple exposures.<\/jats:p>","DOI":"10.4414\/smw.2014.13912","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T09:32:03Z","timestamp":1404379923000},"page":"w13912","source":"Crossref","is-referenced-by-count":1,"title":["Nuclear  power plants and childhood leukaemia: lessons from the past and future  directions"],"prefix":"10.57187","volume":"144","author":[{"given":"Claudia\u00a0Elisabeth","family":"Kuehni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben\u00a0Daniel","family":"Spycher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2014,3,23]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1852\/2587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1852\/2588","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1852\/2587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:22:23Z","timestamp":1755235343000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,23]]},"references-count":0,"journal-issue":{"issue":"1314","published-online":{"date-parts":[[2014,3,24]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2014.13912","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2014,3,23]]}}}