{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T22:30:22Z","timestamp":1775341822006,"version":"3.50.1"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"0708","license":[{"start":{"date-parts":[[2014,2,9]],"date-time":"2014-02-09T00:00:00Z","timestamp":1391904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>BACKGROUND:  Neuroendocrine neoplasms (NENs) are difficult to diagnose. We used SwissNET  data to characterise NEN patients followed in the two academic centres of  western Switzerland (WS), and to compare them with patients followed in eastern  Switzerland (ES) as well as with international guidelines.\n        METHOD: SwissNET  is a prospective database covering data from 522 consecutive patients (285 men,  237 women) from WS (n = 99) and ES (n = 423).\n        RESULTS: Mean  \u00b1 SD age at diagnosis was 59.0 \u00b1 15.7 years. Overall, 76\/522 experienced a  functional syndrome, with a median interval of 1.0 (IQR: 1.0\u20133.0) year between  symptoms onset and diagnosis. A total of 51\/522 of these tumours were  incidental. The primary tumour site was the small intestine (29%), pancreas  (21%), appendix (18%) and lung (11%) in both regions combined. In all, 513  functional imaging studies were obtained (139 in WS, 374 in ES). Of these, 381  were 111In-pentetreotide scintigraphies and 20 were 68Ga-DOTATOC  PET. First line therapy was surgery in 87% of patients, medical therapy  (biotherapy or chemotherapy) in 9% and irradiation in 3% for both regions  together.\n        CONCLUSION:  Swiss NEN patients appear similar to what has been described in the literature.  Imaging by somatostatin receptor scintigraphy (SRS) is widely used in both  regions of Switzerland. In good accordance with published guidelines, data on  first line therapy demonstrate the crucial role of surgery. The low incidence  of biotherapy suggests that long-acting somatostatin analogues are not yet  widely used for their anti-proliferative effects. The SwissNET initiative  should help improve compliance with ENETS guidelines in the workup and care of  NEN patients.<\/jats:p>","DOI":"10.4414\/smw.2014.13924","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T09:32:03Z","timestamp":1404379923000},"page":"w13924","source":"Crossref","is-referenced-by-count":7,"title":["Diagnosis and workup of 522 consecutive patients with neuroendocrine  neoplasms in Switzerland"],"prefix":"10.57187","volume":"144","author":[{"given":"Marine","family":"Gouffon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Iff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Larche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Schwarzenbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Prior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Matter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Stettler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Pralong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2014,2,9]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1826\/2535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1826\/2536","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1826\/2535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:14:59Z","timestamp":1755234899000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,9]]},"references-count":0,"journal-issue":{"issue":"0708","published-online":{"date-parts":[[2014,2,10]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2014.13924","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,9]]}}}