{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:47:44Z","timestamp":1761101264590,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"0910","license":[{"start":{"date-parts":[[2014,2,23]],"date-time":"2014-02-23T00:00:00Z","timestamp":1393113600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>The  purpose of this study was to examine changes in haematopoietic stem cell  transplant (HSCT) characteristics and outcome in our combined paediatric and  adult programme over the past four decades, since its implementation  in 1973. The total number of transplant procedures rose from 109 in the first  decade (1973\u201382) to 939 in the last decade (2003\u201312). Transplant  characteristics changed significantly over time: patient age increased,  peripheral blood largely replaced bone marrow as stem cell source, unrelated  donors became an alternative to matched siblings, and patients are increasingly  transplanted in more advanced disease stages.\n        Advances  such as improved supportive care and histocompatibility typing resulted in a  steady decrease of transplant-related mortality after allogeneic HSCT (43% in the  first decade, 22% in the last decade). Despite this, unadjusted survival rates  were stable in the last three decades for allogeneic HSCT (approximately 50% 5\u2013year  survival) and in the last two decades for autologous HSCT (approximately 60% 5\u2013year  survival). After adjustment for covariates such as donor type, age and stage, the  relative risk of treatment failure continuously dropped (for allogeneic HSCT:  first decade 1.0, second decade 0.58, third decade 0.51, last decade 0.41). Collectively,  these data suggest that improvements in peri- and post-transplant care have  allowed considerable extension of transplant indications without having a  negative impact on outcome.<\/jats:p>","DOI":"10.4414\/smw.2014.13928","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T09:32:03Z","timestamp":1404379923000},"page":"w13928","source":"Crossref","is-referenced-by-count":1,"title":["Forty  years of haematopoietic stem cell transplantation: a\u00a0review\u00a0of\u00a0the\u00a0Basel  experience"],"prefix":"10.57187","volume":"144","author":[{"given":"Alix\u00a0Catherine","family":"O'Meara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Holbro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Medinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Buser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Halter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Heim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Gerull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Bucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Rovo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kuehne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Tichelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alois","family":"Gratwohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Stern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Passweg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2014,2,23]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1835\/2553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1835\/2554","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1835\/2553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:18:50Z","timestamp":1755235130000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,23]]},"references-count":0,"journal-issue":{"issue":"0910","published-online":{"date-parts":[[2014,2,24]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2014.13928","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2014,2,23]]}}}