{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:31:51Z","timestamp":1787499111100,"version":"build-2736575974"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1112","license":[{"start":{"date-parts":[[2014,3,9]],"date-time":"2014-03-09T00:00:00Z","timestamp":1394323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>OBJECTIVE:  To evaluate the rates of penicillin, clindamycin and erythromycin resistance  and the serotype distribution among isolates of group B streptococcus (GBS)  obtained from pregnant women at the University Hospital of Bern in Switzerland.\n        METHODS: We  prospectively collected screening samples for GBS colonisation at the University  Women\u2019s Hospital Bern, Switzerland, between March 2009 and August 2010. We  included 364 GBS isolates collected from vaginal, cervical or vaginal-perianal swabs  at any gestation time. The minimal inhibitory concentrations for penicillin,  clindamycin and erythromycin were established using Etest with 24 hours of incubation,  and inducible clindamycin resistance was tested with double disk diffusion  tests. Serotyping was done with a rapid latex agglutination test or, if not conclusive,  with polymerase chain-reaction (PCR) testing. We looked for significant associations  between resistance patterns, age groups, serotype and ethnicity.\n        RESULTS:  All isolates were susceptible to penicillin. Resistance rates were 14.5% for erythromycin  and 8.2% for clindamycin. Of 364 isolates, 5.8% were susceptible to clindamycin  but not to erythromycin, although demonstrating inducible clindamycin  resistance. Hence, the final reported clindamycin resistance rate was 14%. Serotype  III was the most frequent serotype (29%), followed by V (25%) and Ia (19%). Serotype  V was associated with erythromycin resistance (p = 0.0007). In comparison with all  other ethnicities, patients from Asia showed a higher proportion of  erythromycin and clindamycin resistance (p = 0.018). No significant association  between resistance patterns and age groups was found.\n        CONCLUSION:  In pregnant women with GBS colonisation, penicillin is the antibiotic of choice  for intrapartum prophylaxis to prevent neonatal early-onset GBS sepsis. In  women with penicillin allergy and at high risk for anaphylactic reaction,  clindamycin may be an alternative. The resistance rate for clindamycin at our  institution was 14%; therefore, susceptibility must be tested before administration.<\/jats:p>","DOI":"10.4414\/smw.2014.13935","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T09:32:03Z","timestamp":1404379923000},"page":"w13935","source":"Crossref","is-referenced-by-count":16,"title":["Serotype  distribution and antimicrobial susceptibility of group B streptococci in pregnant  women: results from a Swiss tertiary centre"],"prefix":"10.57187","volume":"144","author":[{"given":"Simone","family":"Fr\u00f6hlicher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Reichen-Fahrni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Surbek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Droz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Spellerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parham","family":"Sendi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2014,3,9]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1843\/2569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1843\/2570","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1843\/2569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:20:33Z","timestamp":1755235233000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,9]]},"references-count":0,"journal-issue":{"issue":"1112","published-online":{"date-parts":[[2014,3,10]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2014.13935","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,9]]}}}