{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:42:39Z","timestamp":1792564959216,"version":"4.5.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1112","license":[{"start":{"date-parts":[[2014,3,9]],"date-time":"2014-03-09T00:00:00Z","timestamp":1394323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>In humans, hantaviruses can cause haemorrhagic fever  with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS). Currently it is estimated that  150,000 to 200,000 cases of hantavirus disease occur each year, the majority  being reported in Asia. However, human hantavirus infections are increasingly  reported in the Americas and Europe. Although many of the underlying pathogenic  mechanisms still remain unclear, recent evidence rather argues against a purely  immune-mediated pathophysiology of human disease. Despite the high morbidity  and case-fatality rates of HFRS and HCPS, respectively, no vaccine or drug is  currently proven to be preventive or therapeutic. This review summarises  clinical features and current epidemiological findings, as well as concepts  regarding the immunology, pathogenesis and intervention strategies of human  hantaviral diseases.<\/jats:p>","DOI":"10.4414\/smw.2014.13937","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T09:32:03Z","timestamp":1404379923000},"page":"w13937","source":"Crossref","is-referenced-by-count":60,"title":["Human  hantavirus infections: epidemiology, clinical features, pathogenesis and  immunology"],"prefix":"10.57187","volume":"144","author":[{"given":"Tobias","family":"Manigold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Vial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2014,3,9]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1844\/2571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1844\/2572","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1844\/2571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:20:44Z","timestamp":1755235244000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,9]]},"references-count":0,"journal-issue":{"issue":"1112","published-online":{"date-parts":[[2014,3,10]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2014.13937","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,9]]}}}