{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:03:16Z","timestamp":1788469396821,"version":"build-2803163510"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1314","license":[{"start":{"date-parts":[[2014,3,23]],"date-time":"2014-03-23T00:00:00Z","timestamp":1395532800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>BACKGROUND AND STUDY PURPOSE: To assess the incidence of cardiac and metabolic adverse events in very low birth weight (VLBW) infants receiving systematic steroids.\n        PATIENTS AND METHODS: Prospective single centre audit in VLBW infants (&lt;1,500 g) at the neonatal intensive care unit at the University Children\u2019s Hospital of Saarland, Germany.\n        RESULTS: A total of 72 VLBW infants (38 female) were included in this report (mean birth weight: 967 \u00b1 338 g; range: 320\u20131490 g). Birth weight, gestational age and Apgar scores were significantly lower in the steroid group (p &lt;0.01). Mortality rate was 8\/72 (7\/34 in the steroid treated vs nontreated 1\/38; odds ratio [OR]: 9.6; 95% confidence interval [CI]: 1.1\u201382.6 p = 0.02). In 34\/72 infants, steroids were given (22 hydrocortisone alone; 12 combination of hydrocortisone and dexamethasone). The most common indication for use of steroids was respiratory distress syndrome (RDS) and respiratory insufficiency (30\/34). Adverse events that occurred more often in the steroid group included hypertrophic cardiomyopathy (14\/34 vs 0\/38; p &lt;0.001); thrombus formation (8\/34 vs 1\/38; OR: 11.4; 95% CI: 1.3-96.6; p\u00a0&lt;0.05), hyperglycaemia (27\/34 vs 3\/38; OR: 45.0; 95% CI: 10.6\u2013190.4; p &lt;0.01), hypernatraemia (15\/34 vs 7\/38; OR: 3.5; 95% CI: 1.2\u201310.1; p\u00a0&lt;0.05), and sepsis\/infections (8\/34 vs 1\/38; OR: 11.4; 95% CI: 1.3\u201396.6; p\u00a0&lt;0.05). No significant differences were seen between hydrocortisone alone and the combination of hydrocortisone with dexamethasone. Birth weight and severity of RDS were predictors of steroid use (p &lt;0.01).\n        CONCLUSIONS: The use of steroids was significantly associated with severe short-term adverse events \u2013 most importantly hypertrophic cardiomyopathy and thrombus formation. These complications must be taken into consideration when administering steroids to VLBW infants.<\/jats:p>","DOI":"10.4414\/smw.2014.13954","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T09:32:03Z","timestamp":1404379923000},"page":"w13954","source":"Crossref","is-referenced-by-count":8,"title":["Non-neurological, steroid-related adverse events in very low birth weight infants: a\u00a0prospective audit"],"prefix":"10.57187","volume":"144","author":[{"given":"Sebastian Benedikt","family":"R\u00f6hr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Gottschling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashim","family":"Abdul-Khaliq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Gortner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Nunold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gr\u00e4ber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2014,3,23]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1845\/2573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1845\/2574","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1845\/2573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:20:56Z","timestamp":1755235256000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,23]]},"references-count":0,"journal-issue":{"issue":"1314","published-online":{"date-parts":[[2014,3,24]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2014.13954","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,23]]}}}