{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:29:14Z","timestamp":1755793754678,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"3334","license":[{"start":{"date-parts":[[2014,8,10]],"date-time":"2014-08-10T00:00:00Z","timestamp":1407628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>SETTING: A  950 bed teaching hospital in Switzerland.\n        AIM: To  describe the result of a contact investigation among health care workers (HCW) and  patients after exposure to a physician with smear-positive pulmonary  tuberculosis in a hospital setting using  standard tuberculin skin tests (TST)  and Interferon-gamma release assay (IGRA).\n        METHOD: HCW  with a negative or unknown TST at hiring had a TST two weeks after the last  contact with the index case (T0), repeated six weeks later if negative (T6). All  exposed HCW had a T-SPOT.TB at T0 and T6. Exposed patients had a TST six weeks  after the last contact, and a T-SPOT.TB if the TST was positive.\n        RESULTS:  Among 101 HCW, 17\/73 (22%) had a positive TST at T0. TST was repeated in 50 at  T6 and converted from negative to positive in eight (16%). Twelve HCW had a  positive T-SPOT.TB at T0 and ten converted from negative to positive at T6.  Seven HCW with a positive T-SPOT.TB reverted to negative at T6 or at later  controls, most of them with test values close to the cut-off. Among 27 exposed  patients tested at six weeks, ten had a positive TST, five of them confirmed by  a positive T-SPOT.TB.\n        CONCLUSIONS:  HCW tested twice after exposure to a case of smear-positive pulmonary TB  demonstrated a possible conversion in 10% with T-SPOT and 16% with TST. Some  T-SPOT.TB reverted from positive to negative during the follow-up, mostly tests  with a value close to the cut-off. Due to the variability of the test results,  it seems advisable to repeat the test with values close to the cut-off before  diagnosing the presence of a tuberculous infection.<\/jats:p>","DOI":"10.4414\/smw.2014.13988","type":"journal-article","created":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T05:41:46Z","timestamp":1420177306000},"page":"w13988","source":"Crossref","is-referenced-by-count":3,"title":["Contact  tracing investigation after professional exposure to tuberculosis in a Swiss hospital  using both tuberculin skin test and IGRA"],"prefix":"10.57187","volume":"144","author":[{"given":"Carlo","family":"Balmelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Zysset","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Pagnamenta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Francioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Lazor-Blanchet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Zanetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Zellweger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2014,8,10]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1897\/2675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1897\/2676","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1897\/2675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:38:12Z","timestamp":1755236292000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,10]]},"references-count":0,"journal-issue":{"issue":"3334","published-online":{"date-parts":[[2014,8,11]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2014.13988","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2014,8,10]]}}}