{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:04:24Z","timestamp":1790532264997,"version":"4.1.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"3738","license":[{"start":{"date-parts":[[2014,9,7]],"date-time":"2014-09-07T00:00:00Z","timestamp":1410048000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Tuberculosis (TB) is one of the oldest diseases known to  mankind, yet it is the second leading cause of death from an infection  worldwide today. In the absence of epidemiological data, TB in children was not  considered significant and research efforts did not prioritise this group. More  recently, there has been renewed interest in childhood TB, leading to improved  understanding of the fundamental differences between children and adults in  relation to both TB infection and disease. Children with TB infection have a  high risk of rapid progression to disease which leads to challenges in  diagnosis but also offers the opportunity to investigate biomarkers for  infection, progression and protection. This review discusses the most relevant  advances in the understanding of epidemiology, diagnosis and prevention of children  with TB. It also highlights challenges and research priorities in childhood TB,  which include better diagnostic tests, accurate correlates of protection and an  improved vaccine.<\/jats:p>","DOI":"10.4414\/smw.2014.14000","type":"journal-article","created":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T05:41:46Z","timestamp":1420177306000},"page":"w14000","source":"Crossref","is-referenced-by-count":22,"title":["Novel concepts in the epidemiology, diagnosis and\u00a0prevention of\u00a0childhood tuberculosis"],"prefix":"10.57187","volume":"144","author":[{"given":"Nicole","family":"Ritz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2014,9,7]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1904\/2689","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1904\/2690","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1904\/2689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:39:49Z","timestamp":1755236389000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,7]]},"references-count":0,"journal-issue":{"issue":"3738","published-online":{"date-parts":[[2014,9,8]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2014.14000","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,7]]}}}