{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:52:45Z","timestamp":1781020365253,"version":"3.54.1"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"5152","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Actinic  keratosis (AK) affects millions of people worldwide, and its prevalence  continues to increase. AK lesions are caused by chronic ultraviolet radiation  exposure, and the presence of two or more AK lesions along with photodamage should  raise the consideration of a diagnosis of field cancerization. Effective  treatment of individual lesions as well as field cancerization is essential for  good long-term outcomes.\n        The Swiss  Registry of Actinic Keratosis Treatment (REAKT) Working Group has developed  clinical practice guidelines for the treatment of field cancerization in  patients who present with AK. These guidelines are intended to serve as a resource  for physicians as to the most appropriate treatment and management of AK and  field cancerization based on current evidence and the combined practical  experience of the authors. Treatment of AK and field cancerization should be  driven by consideration of relevant patient, disease, and treatment factors,  and appropriate treatment decisions will differ from patient to patient. Prevention  measures and screening recommendations are discussed, and special considerations  related to management of immunocompromised patients are provided.<\/jats:p>","DOI":"10.4414\/smw.2014.14026","type":"journal-article","created":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T05:41:46Z","timestamp":1420177306000},"page":"w14026","source":"Crossref","is-referenced-by-count":16,"title":["Swiss  clinical practice guidelines on field cancerization of the skin"],"prefix":"10.57187","volume":"144","author":[{"given":"G\u00fcnther\u00a0FL","family":"Hofbauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Anliker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf-Henning","family":"Boehncke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gaide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Hafner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hunger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Itin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Kaeuper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Lautenschlager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Mainetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Streit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2014,12,15]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1961\/2802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1961\/2803","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1961\/2802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T06:02:17Z","timestamp":1755237737000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,15]]},"references-count":0,"journal-issue":{"issue":"5152","published-online":{"date-parts":[[2014,12,15]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2014.14026","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,15]]}}}