{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:32:23Z","timestamp":1739511143473,"version":"3.37.0"},"reference-count":16,"publisher":"Uniwersytet Jagiellonski - Wydawnictwo Uniwersytetu Jagiellonskiego","issue":"1","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/deed.pl"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AMSIK"],"abstract":"<jats:p>Biologia molekularna i genetyka dysponuj\u0105 mo\u017cliwo\u015bciami diagnostyki wielu schorze\u0144, kt\u00f3rych obecno\u015b\u0107 lub nieobecno\u015b\u0107 ma istotne znaczenie w r\u00f3\u017cnych obszarach opiniowania s\u0105dowo-lekarskiego. Celem pracy jest zaprezentowanie przyk\u0142ad\u00f3w mo\u017cliwego zastosowania tego rodzaju bada\u0144 w medycynie s\u0105dowej. Spo\u015br\u00f3d opinii opracowanych w Zak\u0142adzie Medycyny S\u0105dowej w Katowicach wybrano trzy, z kt\u00f3rych dwie dotyczy\u0142y wniosk\u00f3w posekcyjnych odnosz\u0105cych si\u0119 do przyczyny zgonu, natomiast w jednym przypadku \u2013 opinii na podstawie akt sprawy maj\u0105cej zwi\u0105zek z podejrzeniem zespo\u0142u dziecka maltretowanego. We wszystkich tych przypadkach wyniki przeprowadzonych bada\u0144 molekularno-genetycznych by\u0142y ujemne, co zosta\u0142o uwzgl\u0119dnione przez bieg\u0142ych podczas formu\u0142owania ostatecznych wniosk\u00f3w. Zastosowanie klinicznych bada\u0144 molekularno-genetycznych w medycynie s\u0105dowej jest mo\u017cliwe i zawsze wnosi istotne informacje rozszerzaj\u0105ce mo\u017cliwo\u015bci opiniodawcze i u\u0142atwiaj\u0105ce postawienie rozpoznania. Obszarami, w kt\u00f3rych tego rodzaju badania mog\u0105 by\u0107 szczeg\u00f3lnie przydatne, s\u0105: diagnostyka pod\u0142o\u017ca powik\u0142a\u0144 zakrzepowo-zatorowych, nowoczesna zintegrowana diagnostyka morfologiczno-molekularna nowotwor\u00f3w oraz diagnostyka defekt\u00f3w genetycznych tkanki \u0142\u0105cznej u dzieci podejrzanych o zesp\u00f3\u0142 dziecka maltretowanego.\n\n\nThe use of clinical molecular and genetic tests in forensic medical opinions\n\nModern molecular biology and clinical genetics have the ability to diagnose many diseases, the presence or absence of which is important in various areas of forensic medical opinion. The aim of the study is to present examples of possible non-standard application of clinical molecular-genetic tests in forensic medicine. From among all the opinions prepared so far at the Department of Forensic Medicine in Katowice, three were selected two of which concerned post-autopsy conclusions relating to the cause of death, and in one case \u2013 opinion based on the files of a case related to the suspicion of a maltreated child syndrome in an infant. In all these cases, the results of the molecular and genetic tests were negative, which was taken into account by the experts when formulating the final conclusions of the opinion. The use of clinical molecular and genetic tests in forensic medicine is possible and always brings important additional information that broadens the possibilities of opinion-making and facilitates diagnosis. The areas in which this type of research may be particularly useful are: diagnostics of the basis of thromboembolic complications, modern integrated morphological and molecular diagnostics of neoplasms and diagnostics of genetic defects of connective tissue in children suspected of having abused child syndrome.<\/jats:p>","DOI":"10.4467\/16891716amsik.22.005.16234","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T11:54:22Z","timestamp":1663329262000},"page":"47-52","source":"Crossref","is-referenced-by-count":0,"title":["Wykorzystanie klinicznych bada\u0144 molekularno-genetycznych w opiniowaniu s\u0105dowo-lekarskim"],"prefix":"10.4467","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-3807","authenticated-orcid":false,"given":"Rafa\u0142","family":"Skowronek","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine and Forensic Toxicology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10051","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"ref0","unstructured":"1. 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