{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:50:16Z","timestamp":1775148616320,"version":"3.50.1"},"reference-count":90,"publisher":"American Spinal Injury Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"abstract":"\n Background:<\/jats:title>\n People with spinal cord injury (SCI) present with impaired autonomic control when the lesion is above T6. This could lead to delayed cardiorespiratory recovery following vigorous physical activity.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n To characterize and compare gas exchange off-kinetics following exhaustive exercise in individuals with SCI and an apparently healthy control group.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Participants were 19 individuals with SCI who presented with the inability to voluntarily lift their legs against gravity (age, 44.6 \u00b1 14.2 years; AIS A,\n n<\/jats:italic>\n = 5; AIS B,\n n<\/jats:italic>\n = 7; AIS C,\n n<\/jats:italic>\n = 7; paraplegia,\n n<\/jats:italic>\n = 14; tetraplegia,\n n<\/jats:italic>\n = 5) and 10 healthy comparisons (COM; age, 30.5 \u00b1 5.3 years). All participants performed an arm ergometer cardiopulmonary exercise test (aCPET) to volitional exhaustion followed by a 10-minute passive recovery. O\n 2<\/jats:sub>\n uptake (\n \n V\u0307o\n 2<\/jats:sub>\n <\/jats:italic>\n ) and CO\n 2<\/jats:sub>\n output (\n \n V\u0307co\n 2<\/jats:sub>\n <\/jats:italic>\n ) off-kinetics was examined using a mono-exponential model in which tau\n off<\/jats:italic>\n (\n \n \u03c4\n off<\/jats:sub>\n <\/jats:italic>\n ) and mean response time (MRT) were determined. The off-kinetics transition constant (\n \n Kt\n off<\/jats:sub>\n <\/jats:italic>\n ) was calculated as \u0394\n \n V\u0307o\n 2<\/jats:sub>\n <\/jats:italic>\n \/MRT. Student\n t<\/jats:italic>\n tests were used to compare SCI versus COM group means.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n COM had a significantly higher relative peak\n \n V\u0307o\n 2<\/jats:sub>\n <\/jats:italic>\n compared to SCI (1.70 \u00b1 0.55 L\/min vs 1.19 \u00b1 0.51 L\/min,\n p<\/jats:italic>\n = .019). No difference was observed for\n \n \u03c4\n off<\/jats:sub>\n <\/jats:italic>\n between the groups, however\n \n Kt\n off<\/jats:sub>\n <\/jats:italic>\n for both\n \n V\u0307o\n 2<\/jats:sub>\n <\/jats:italic>\n and\n \n V\u0307co\n 2<\/jats:sub>\n <\/jats:italic>\n was significantly lower in the SCI compared to the COM group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n A reduced\n \n Kt\n off<\/jats:sub>\n <\/jats:italic>\n during recovery may suggest inefficiencies in replenishing muscle ATP stores and lactate clearance in these participants with SCI. These findings may contribute to the observed lower cardiorespiratory fitness and greater fatigability typically reported in individuals with SCI.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.46292\/sci19-00060","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T14:25:08Z","timestamp":1611930308000},"page":"304-313","source":"Crossref","is-referenced-by-count":3,"title":["Recovery Off-Kinetics Following Exhaustive Upper Body Exercise in Spinal Cord Injury"],"prefix":"10.46292","volume":"26","author":[{"given":"Donal","family":"Murray","sequence":"first","affiliation":[{"name":"Department of Kinesiology, Western Illinois University, Macomb, Illinois"},{"name":"Department of Rehabilitation Science, George Mason University, Fairfax, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.K.","family":"Chin","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel E.","family":"Cowan","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne L.","family":"Groah","sequence":"additional","affiliation":[{"name":"MedStar National Rehabilitation Hospital, Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall E.","family":"Keyser","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Science, George Mason University, Fairfax, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"25425","reference":[{"issue":"8","key":"i1082-0744-26-4-304-b1","series-title":"Spinal Cord","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/sc.2009.196","article-title":"Post-exercise heart rate recovery in 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