{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:53:29Z","timestamp":1787320409754,"version":"build-2736575974"},"reference-count":76,"publisher":"American Spinal Injury Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Secondary health conditions (SHC) are physical and mental health conditions that are causally related to disabilities. Studies have found that SHC increase risk of negative health outcomes among people with traumatic spinal cord injury (TSCI). However, little has been done to assess the association of SHC with the risk of chronic health conditions (CHC) after TSCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To identify the prevalence of CHC in adults with TSCI, changes in CHC at follow-up, and the associations of baseline SHC with future CHC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Participants included 501 adults with TSCI of at least 1-year duration, identified through a population-based surveillance system. Baseline and follow-up self-report assessments were completed. We measured seven SHC: fatigue, spasticity, pain, pressure ulcers, subsequent injury, fracture, and anxiety disorder, and measured seven CHC: diabetes, heart attack, coronary artery disease, stroke, cancer, hypertension, and high blood cholesterol. Control variables included gender, race\/ethnicity, age at injury, years post injury, injury severity, smoking status, binge drinking, and taking prescription medication. We implemented a Poisson regression model for the multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The total number of CHC, the percentage of participants having at least one CHC, and prevalence of three individual CHC (diabetes, cancer, and high cholesterol) increased from baseline to follow-up. After controlling for demographic, injury characteristics, and behavioral factors, pain interference and anxiety disorder at baseline were associated with the total number of CHC at follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CHC are common among adults with TSCI and increase significantly over time. Pain and anxiety disorders appear to be risk factors for future CHC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.46292\/sci20-00020","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T14:25:53Z","timestamp":1611930353000},"page":"283-289","source":"Crossref","is-referenced-by-count":23,"title":["Association of Secondary Health Conditions With Future Chronic Health Conditions Among Persons With Traumatic Spinal Cord Injury"],"prefix":"10.46292","volume":"26","author":[{"given":"Yue","family":"Cao","sequence":"first","affiliation":[{"name":"College of Health Professions, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"DiPiro","sequence":"additional","affiliation":[{"name":"College of Health Professions, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Krause","sequence":"additional","affiliation":[{"name":"College of Health Professions, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25425","reference":[{"issue":"5","key":"i1082-0744-26-4-283-b1","series-title":"Spinal Cord","first-page":"373","article-title":"Secondary health conditions in individuals aging with SCI: Terminology, concepts and analytic approaches","volume":"50","year":"2012","unstructured":"Jensen\n              MP,\n            \n            \n              Molton\n              IR,\n            \n            \n              Groah\n              SL,\n            \n          \n          .\n\t\t\t\t\tSecondary health conditions in individuals aging with SCI: Terminology, concepts and analytic approaches.\n\t\t\t\t\tSpinal 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  Chung,\n              O.Y.,\n            \n            \n              Jirjis,\n              J.N.,\n            \n            \n              Biridapalli,\n              S.\n            \n          \n          Prevalence of clinical hypertension in patients with chronic pain compared to nonpain general medical patients.\n\t\t\t\t\tClin J Pain.\n\t\t\t\t\t2005;\n\t\t\t\t\t21(\n\t\t\t\t\t2):\n\t\t\t\t\t147\u2013\n\t\t\t\t\t153."},{"issue":"3","key":"i1082-0744-26-4-283-b32","series-title":"Neuroepidemiology","first-page":"130","article-title":"Neuropathic pain, depression, and cardiovascular disease: A national multicenter study","volume":"44","year":"2015","unstructured":"Cragg\n              JJ,\n            \n            \n              Noonan\n              VK,\n            \n            \n              Noreau\n              L,\n            \n            \n              Borisoff\n              JF,\n            \n            \n              Kramer\n              JK.\n            \n          \n          Neuropathic pain, depression, and cardiovascular disease: A national multicenter study.\n\t\t\t\t\tNeuroepidemiology.\n\t\t\t\t\t2015;\n\t\t\t\t\t44(\n\t\t\t\t\t3):\n\t\t\t\t\t130\u2013\n\t\t\t\t\t137."},{"issue":"6","key":"i1082-0744-26-4-283-b33","series-title":"Eur Arch Psychiatry Clin Neurosci","first-page":"313","article-title":"Associations between anxiety disorders and physical illness","volume":"253","year":"2003","unstructured":"Harter,\n              MC,\n            \n            \n              Conway,\n              KP,\n            \n            \n              Merikangas,\n              KR.\n            \n          \n          Associations between anxiety disorders and physical illness.\n\t\t\t\t\tEur Arch Psychiatry Clin Neurosci.\n\t\t\t\t\t2003;\n\t\t\t\t\t253(\n\t\t\t\t\t6):\n\t\t\t\t\t313\u2013\n\t\t\t\t\t320."},{"issue":"3","key":"i1082-0744-26-4-283-b34","series-title":"Gen Hosp Psychiatry","first-page":"208","article-title":"Anxiety disordres and comorbid medical illness","volume":"30","year":"2008","unstructured":"Roy-Byrne,\n              PP,\n            \n            \n              Davidson,\n              KW,\n            \n            \n              Kessler,\n              RC,\n            \n          \n          .\n\t\t\t\t\tAnxiety disordres and comorbid medical illness.\n\t\t\t\t\tGen Hosp Psychiatry.\n\t\t\t\t\t2008;\n\t\t\t\t\t30(\n\t\t\t\t\t3):\n\t\t\t\t\t208\u2013\n\t\t\t\t\t225."},{"issue":"6","key":"i1082-0744-26-4-283-b35","series-title":"Arch Phys Med Rehabil","first-page":"1054","article-title":"Risk of death after hospital discharge with traumatic spinal cord injury: A population-based analysis, 1998\u20132009","volume":"94","year":"2013","unstructured":"Cao\n              Y,\n            \n            \n              Selassie\n              AW,\n            \n            \n              Krause\n              JS.\n            \n          \n          Risk of death after hospital discharge with traumatic 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Accessed August 22, 2012."},{"key":"i1082-0744-26-4-283-b37","series-title":"Fatigue and Multiple Sclerosis: Evidence-Based Management of Strategies for Fatigue in Multiple Sclerosis.","year":"1998","unstructured":"Multiple Sclerosis Council for Clinical Practice Guidelines.\n\t\t\t\t\tFatigue and Multiple Sclerosis: Evidence-Based Management of Strategies for Fatigue in Multiple Sclerosis.Washington, DC:\n\t\t\t\t\tParalyzed Veterans of America;\n\t\t\t\t\t1998."},{"key":"i1082-0744-26-4-283-b38","series-title":"Ann Acad Med, Singapore","first-page":"129","article-title":"Pain assessment: Global use of the Brief Pain Inventory","volume":"23","year":"1994","unstructured":"Cleeland\n              CS,\n            \n            \n              Ryan\n              KM.\n            \n          \n          Pain assessment: Global use of the Brief Pain Inventory.\n\t\t\t\t\tAnn Acad Med, 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         Clarke\n              A,\n            \n            \n              Tate\n              DG,\n            \n            \n              Forchheimer\n              M,\n            \n            \n              Krause\n              JS.\n            \n          \n          Lifetime prevalence of chronic health conditions among persons with spinal cord injury.\n\t\t\t\t\tArch Phys Med Rehabil.\n\t\t\t\t\t2015;\n\t\t\t\t\t96(\n\t\t\t\t\t4):\n\t\t\t\t\t673\u2013\n\t\t\t\t\t679."},{"issue":"12","key":"i1082-0744-26-4-283-b4","series-title":"Phys Ther","first-page":"1728","article-title":"A conceptual model for identifying, preventing, and managing secondary conditions in people with disabilities","volume":"91","year":"2011","unstructured":"Rimmer\n              JH,\n            \n            \n              Chen\n              MD,\n            \n            \n              Hsieh\n              K.\n            \n          \n          A conceptual model for identifying, preventing, and 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          Noonan\n              VK,\n            \n            \n              Krassioukov\n              A,\n            \n            \n              Borisoff\n              J.\n            \n          \n          Cardiovascular disease and spinal cord injury: Results from a national population health survey.\n\t\t\t\t\tNeurology.\n\t\t\t\t\t2013;\n\t\t\t\t\t81(\n\t\t\t\t\t8):\n\t\t\t\t\t723\u2013\n\t\t\t\t\t728."},{"issue":"1","key":"i1082-0744-26-4-283-b10","series-title":"Arch Phys Med Rehabil","first-page":"90","article-title":"Males aging with a spinal cord injury: Prevalence of cardiovascular and metabolic conditions","volume":"93","year":"2012","unstructured":"LaVela\n              SL,\n            \n            \n              Evans\n              CT,\n            \n            \n              Prohaska\n              TR,\n            \n            \n              Miskevics\n              S,\n            \n            \n              Ganesh\n              SP,\n            \n            \n              Weaver\n              FM.\n            \n          \n          Males aging with a spinal cord injury: Prevalence of cardiovascular and metabolic conditions.\n\t\t\t\t\tArch Phys Med Rehabil.\n\t\t\t\t\t2012;\n\t\t\t\t\t93(\n\t\t\t\t\t1):\n\t\t\t\t\t90\u2013\n\t\t\t\t\t95."},{"key":"i1082-0744-26-4-283-b11","series-title":"Am J Phys Med Rehabil","first-page":"142","article-title":"Cardiovascular disease in spinal cord injury: An overview of prevalence, risk, evaluation, and management","volume":"86","year":"2007","unstructured":"Myers\n              J,\n            \n            \n              Lee\n              M,\n            \n            \n              Kiralti\n              J.\n            \n          \n          Cardiovascular disease in spinal cord injury: An overview of prevalence, risk, evaluation, and management.\n\t\t\t\t\tAm J Phys Med 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   K,\n            \n            \n              Nash\n              MS,\n            \n            \n              Lewis\n              JE,\n            \n            \n              Seiger\n              A,\n            \n            \n              Levi\n              R.\n            \n          \n          Increased cardiovascular disease risk in Swedish persons with paraplegia: The Stockholm spinal cord injury study.\n\t\t\t\t\tJ Rehabil Med.\n\t\t\t\t\t2010;\n\t\t\t\t\t42(\n\t\t\t\t\t5):\n\t\t\t\t\t489\u2013\n\t\t\t\t\t492."},{"issue":"1","key":"i1082-0744-26-4-283-b15","series-title":"Spinal Cord","first-page":"33","article-title":"Prevalence of chronic health conditions and hospital utilization in adults with spinal cord injury: an analysis of self-report and South Carolina administrative billing data","volume":"57","year":"2019","unstructured":"DiPiro\n              ND,\n            \n            \n              Murday\n              D,\n            \n            \n            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study.\n\t\t\t\t\tNeurology.\n\t\t\t\t\t2012;\n\t\t\t\t\t78(\n\t\t\t\t\t14):\n\t\t\t\t\t1051\u2013\n\t\t\t\t\t1057."},{"issue":"9","key":"i1082-0744-26-4-283-b17","series-title":"Disabil Rehabil","first-page":"919","article-title":"Prevalence of hypertension and associated risk factors in people with long-term spinal cord injury living in the Netherlands","volume":"39","year":"2017","unstructured":"Adriaansen\n              JJ,\n            \n            \n              Douma-Haan\n              Y,\n            \n            \n              van Asbeck\n              FW,\n            \n          \n          .\n\t\t\t\t\tPrevalence of hypertension and associated risk factors in people with long-term spinal cord injury living in the Netherlands.\n\t\t\t\t\tDisabil Rehabil.\n\t\t\t\t\t2017;\n\t\t\t\t\t39(\n\t\t\t\t\t9):\n\t\t\t\t\t919\u2013\n\t\t\t\t\t927."},{"issue":"21","key":"i1082-0744-26-4-283-b18","series-title":"Neurology","first-page":"1864","article-title":"Spinal cord injury and 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     Weaver\n              FM,\n            \n            \n              Goldstein\n              B,\n            \n          \n          .\n\t\t\t\t\tDiabetes mellitus in individuals with spinal cord injury or disorder.\n\t\t\t\t\tJ Spinal Cord Med.\n\t\t\t\t\t2006;\n\t\t\t\t\t29(\n\t\t\t\t\t4):\n\t\t\t\t\t387\u2013\n\t\t\t\t\t395."},{"issue":"3","key":"i1082-0744-26-4-283-b20","series-title":"Disabil Health J","first-page":"533","article-title":"Self-reported incidence and age of onset of chronic comorbid medical conditions in adults aging with long-term physical disability","volume":"9","year":"2016","unstructured":"Smith\n              AE,\n            \n            \n              Molton\n              IR,\n            \n            \n              Jensen\n              MP.\n            \n          \n          Self-reported incidence and age of onset of chronic comorbid medical conditions in adults aging with long-term physical disability.\n\t\t\t\t\tDisabil Health J.\n\t\t\t\t\t2016;\n\t\t\t\t\t9(\n\t\t\t\t\t3):\n\t\t\t\t\t533\u2013\n\t\t\t\t\t538."},{"key":"i1082-0744-26-4-283-b21","series-title":"Arch Phys Med Rehabil","first-page":"1757","article-title":"Etiology and incidence of rehospitalization after traumatic spinal cord injury: A multicenter analysis","volume":"85","year":"2004","unstructured":"Cardenas\n              D,\n            \n            \n              Hoffman\n              J,\n            \n            \n              Kirshblum\n              S,\n            \n            \n              McKinley\n              W.\n            \n          \n          Etiology and incidence of rehospitalization after traumatic spinal cord injury: A multicenter analysis.\n\t\t\t\t\tArch Phys Med Rehabil.\n\t\t\t\t\t2004;\n\t\t\t\t\t85:\n\t\t\t\t\t1757\u2013\n\t\t\t\t\t1763."},{"issue":"6","key":"i1082-0744-26-4-283-b22","series-title":"Spinal Cord","first-page":"359","article-title":"Patterns of morbidity and rehospitalisation following spinal 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hospitalizations among persons with spinal cord injury.\n\t\t\t\t\tTop Spinal Cord Inj Rehabil.\n\t\t\t\t\t2011;\n\t\t\t\t\t16(\n\t\t\t\t\t4):\n\t\t\t\t\t53\u2013\n\t\t\t\t\t61."},{"issue":"8","key":"i1082-0744-26-4-283-b24","series-title":"Injury","first-page":"1847","article-title":"Profile and costs of secondary conditions resulting in emergency department presentations and readmission to hospital following traumatic spinal cord injury","volume":"47","year":"2016","unstructured":"Gabbe\n              BJ,\n            \n            \n              Nunn\n              A.\n            \n          \n          Profile and costs of secondary conditions resulting in emergency department presentations and readmission to hospital following traumatic spinal cord injury.\n\t\t\t\t\tInjury.\n\t\t\t\t\t2016;\n\t\t\t\t\t47(\n\t\t\t\t\t8):\n\t\t\t\t\t1847\u2013\n\t\t\t\t\t1855."},{"key":"i1082-0744-26-4-283-b25","series-title":"Arch Phys Med Rehabil.","article-title":"Concentration of costs among high utilizers of health care services over the first 10 years after spinal cord injury rehabilitation: A population-based study [online publication December 6, 2018]","unstructured":"Krause\n              JS,\n            \n            \n              Murday\n              D,\n            \n            \n              Corley\n              EH,\n            \n            \n              DiPiro\n              ND.\n            \n          \n          Concentration of costs among high utilizers of health care services over the first 10 years after spinal cord injury rehabilitation: A population-based study [online publication December 6, 2018].\n\t\t\t\t\tArch Phys Med Rehabil."},{"issue":"3\u20134","key":"i1082-0744-26-4-283-b26","series-title":"Neuroepidemiology","first-page":"205","article-title":"Comparison of all-cause and cause-specific mortality of persons with traumatic spinal cord injuries to the general Swiss population: Results from a national cohort 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