{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:26:07Z","timestamp":1779222367201,"version":"3.51.4"},"reference-count":112,"publisher":"American Spinal Injury Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Transverse myelitis (TM) in childhood is a rare disorder characterized by the presence of spinal cord inflammation. Gait difficulty in children with TM is common; however, there is a paucity of literature regarding quantitative assessment of gait in children and adolescents with TM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To characterize gait patterns in a cohort of ambulatory children with TM and age-matched, typically developing peers in order to better understand the functional mobility of patients diagnosed with childhood TM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective study of 26 ambulatory pediatric patients with a confirmed diagnosis of TM who had undergone three-dimensional, instrumented gait analysis (3D-IGA) at 3 years of age or older. A group of 38 typically developing children served as a control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Gait in children with TM was characterized by moderate kinematic deviations as measured by the Gait Deviation Index (GDI) and a crouched gait pattern (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001), increased anterior pelvic tilt (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001), decreased motion at the knees (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001), and a wider base of support (foot progression angle,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001). The TM group had a slower walking speed (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001), shorter strides (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001), and an increased stance phase compared to controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study results showed moderate kinematic deviations quantified by the GDI. Overall, the gait pattern in the TM population tested had greater hip and knee flexion with wider foot progression angle. Identification of gait characteristics in children with TM is the first step in predicting changes in gait pattern as they mature over time, which may ultimately allow for targeted intervention to maintain their ambulatory function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.46292\/sci20-00048","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T17:07:51Z","timestamp":1628874471000},"page":"38-48","source":"Crossref","is-referenced-by-count":6,"title":["Gait Characteristics in Youth With Transverse Myelitis"],"prefix":"10.46292","volume":"27","author":[{"given":"Miriam","family":"Hwang","sequence":"first","affiliation":[{"name":"Shriners Hospitals for Children, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Shriners Hospitals for Children, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Graf","sequence":"additional","affiliation":[{"name":"Shriners Hospitals for Children, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M.","family":"Kruger","sequence":"additional","affiliation":[{"name":"Shriners Hospitals for Children, Chicago, Illinois"},{"name":"Marquette University, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Scullion","sequence":"additional","affiliation":[{"name":"Shriners Hospitals for Children, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Tayne","sequence":"additional","affiliation":[{"name":"Phoenix Children\u2019s Hospital, Phoenix, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haluk","family":"Altiok","sequence":"additional","affiliation":[{"name":"Shriners Hospitals for Children, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"25425","reference":[{"key":"i1082-0744-27-3-38-b1","series-title":"Transverse myelitis.","year":"2020","unstructured":"Simone\n              CG,\n            \n            \n              Emmady\n              PD.\n            \n          \n          \n            Transverse myelitis.\n          \n          2020;\n\t\t\t\t\t2020 Jan. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559302\/."},{"issue":"4","key":"i1082-0744-27-3-38-b2","series-title":"Neurology","first-page":"499","article-title":"Proposed diagnostic criteria and nosology of acute transverse myelitis","volume":"59","year":"2002","unstructured":"Transverse Myelitis Consortium Working Group.\n          \n          Proposed diagnostic criteria and nosology of acute transverse 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discriminate the implication of iliopsoas, hamstring and gastrocnemius contractures to a knee flexion gait.\n\t\t\t\t\tGait Posture.\n\t\t\t\t\t2019;\n\t\t\t\t\t68:\n\t\t\t\t\t415\u2013\n\t\t\t\t\t422."},{"issue":"10","key":"i1082-0744-27-3-38-b34","series-title":"PLoS Comp Biol","first-page":"e1006993","article-title":"Predicting gait adaptations due to ankle plantarflexor weakness and contracture using physics-based musculoskeletal simulations","volume":"15","year":"2019","unstructured":"Ong\n              CF,\n            \n            \n              Geijtenbeek\n              T,\n            \n            \n              Hicks\n              JL,\n            \n            \n              Delp\n              SL.\n            \n          \n          Predicting gait adaptations due to ankle plantarflexor weakness and contracture using physics-based musculoskeletal simulations.\n\t\t\t\t\tPLoS Comp Biol.\n\t\t\t\t\t2019;\n\t\t\t\t\t15(\n\t\t\t\t\t10):\n\t\t\t\t\te1006993."},{"issue":"4","key":"i1082-0744-27-3-38-b35","series-title":"J Pediatr Orthop B","first-page":"265","article-title":"An update on the treatment of gait problems in cerebral palsy","volume":"10","year":"2001","unstructured":"Gage\n              JR,\n            \n            \n              Novacheck\n              TF.\n            \n          \n          An update on the treatment of gait problems in cerebral palsy.\n\t\t\t\t\tJ Pediatr Orthop B.\n\t\t\t\t\t2001;\n\t\t\t\t\t10(\n\t\t\t\t\t4):\n\t\t\t\t\t265\u2013\n\t\t\t\t\t274."},{"key":"i1082-0744-27-3-38-b36","series-title":"J Appl Biomater Biomech","first-page":"98","article-title":"Gait analysis before and after gastrocnemius fascia lengthening in children with cerebral palsy","volume":"3","year":"2005","unstructured":"Galli\n              M,\n            \n            \n              Cimolin\n              V,\n            \n            \n              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during gait in children with cerebral palsy: A cross-sectional study with 3-dimensional kinematics and lower lumbar spinal loading","volume":"98","year":"2018","unstructured":"Kiernan\n              D,\n            \n            \n              O\u2019Sullivan\n              R,\n            \n            \n              Malone\n              A,\n            \n            \n              O\u2019Brien\n              T,\n            \n            \n              Simms\n              CK.\n            \n          \n          Pathological movements of the pelvis and trunk during gait in children with cerebral palsy: A cross-sectional study with 3-dimensional kinematics and lower lumbar spinal loading.\n\t\t\t\t\tPhys Ther.\n\t\t\t\t\t2018;\n\t\t\t\t\t98(\n\t\t\t\t\t2):\n\t\t\t\t\t86\u2013\n\t\t\t\t\t94."},{"issue":"2","key":"i1082-0744-27-3-38-b41","series-title":"Gait Posture","first-page":"196","article-title":"Computerized gait analysis in Legg Calve Perthes disease - analysis of the frontal plane","volume":"24","year":"2006","unstructured":"Westhoff\n              B,\n            \n            \n              Petermann\n              A,\n            \n            \n              Hirsch\n              MA,\n            \n            \n              Willers\n              R,\n            \n            \n              Krauspe\n              R.\n            \n          \n          Computerized gait analysis in Legg Calve Perthes disease - analysis of the frontal plane.\n\t\t\t\t\tGait Posture.\n\t\t\t\t\t2006;\n\t\t\t\t\t24(\n\t\t\t\t\t2):\n\t\t\t\t\t196\u2013\n\t\t\t\t\t202."},{"key":"i1082-0744-27-3-38-b42","series-title":"Clin Biomech","first-page":"105013","article-title":"Trunk biomechanics during walking after sub-acute stroke and its relation to lower limb impairments","volume":"75","year":"2020","unstructured":"Van Criekinge\n              T,\n            \n            \n              Wim\n              S,\n            \n            \n              Herssens\n   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scales","volume":"4","year":"2006","unstructured":"Cremeens\n              J,\n            \n            \n              Eiser\n              C,\n            \n            \n              Blades\n              M.\n            \n          \n          Factors influencing agreement between child self-report and parent-reports on the Pediatric Quality of Life Inventory 4.0 (PedsQL) generic core scales.\n\t\t\t\t\tHealth Qual Life Outcomes.\n\t\t\t\t\t2006;\n\t\t\t\t\t4:\n\t\t\t\t\t58."},{"key":"i1082-0744-27-3-38-b1","series-title":"Transverse myelitis.","year":"2020","unstructured":"Simone\n              CG,\n            \n            \n              Emmady\n              PD.\n            \n          \n          \n            Transverse myelitis.\n          \n          2020;\n\t\t\t\t\t2020 Jan. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559302\/."},{"issue":"4","key":"i1082-0744-27-3-38-b2","series-title":"Neurology","first-page":"499","article-title":"Proposed diagnostic criteria and nosology of acute transverse myelitis","volume":"59","year":"2002","unstructured":"Transverse Myelitis Consortium Working Group.\n          \n          Proposed diagnostic criteria and nosology of acute transverse myelitis.\n\t\t\t\t\tNeurology.\n\t\t\t\t\t2002;\n\t\t\t\t\t59(\n\t\t\t\t\t4):\n\t\t\t\t\t499\u2013\n\t\t\t\t\t505."},{"issue":"18","key":"i1082-0744-27-3-38-b3","series-title":"Neurology","first-page":"1474","article-title":"Acute transverse myelitis in childhood: Center-based analysis of 47 cases","volume":"68","year":"2007","unstructured":"Pidcock\n              FS,\n            \n            \n              Krishnan\n              C,\n            \n            \n              Crawford\n              TO,\n            \n            \n              Salorio\n              CF,\n            \n            \n              Trovato\n              M,\n            \n            \n              Kerr\n              DA.\n            \n          \n          Acute transverse myelitis in 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Rep","first-page":"236","article-title":"Demyelinating disorders: update on transverse myelitis","volume":"6","year":"2006","unstructured":"Krishnan\n              C,\n            \n            \n              Kaplin\n              AI,\n            \n            \n              Pardo\n              CA,\n            \n            \n              Kerr\n              DA,\n            \n            \n              Keswani\n              SC.\n            \n          \n          Demyelinating disorders: update on transverse myelitis.\n\t\t\t\t\tCurr Neurol Neurosci Rep.\n\t\t\t\t\t2006;\n\t\t\t\t\t6(\n\t\t\t\t\t3):\n\t\t\t\t\t236\u2013\n\t\t\t\t\t243."},{"issue":"4","key":"i1082-0744-27-3-38-b9","series-title":"Continuum (Minneap Minn)","first-page":"816","article-title":"Rehabilitation in transverse myelitis","volume":"17","year":"2011","unstructured":"Sadowsky\n              CL,\n            \n            \n              Becker\n              D,\n            \n            \n              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frontal plane","volume":"24","year":"2006","unstructured":"Westhoff\n              B,\n            \n            \n              Petermann\n              A,\n            \n            \n              Hirsch\n              MA,\n            \n            \n              Willers\n              R,\n            \n            \n              Krauspe\n              R.\n            \n          \n          Computerized gait analysis in Legg Calve Perthes disease - analysis of the frontal plane.\n\t\t\t\t\tGait Posture.\n\t\t\t\t\t2006;\n\t\t\t\t\t24(\n\t\t\t\t\t2):\n\t\t\t\t\t196\u2013\n\t\t\t\t\t202."},{"key":"i1082-0744-27-3-38-b42","series-title":"Clin Biomech","first-page":"105013","article-title":"Trunk biomechanics during walking after sub-acute stroke and its relation to lower limb impairments","volume":"75","year":"2020","unstructured":"Van Criekinge\n              T,\n            \n            \n              Wim\n              S,\n            \n            \n              Herssens\n   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