{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:53:29Z","timestamp":1775148809003,"version":"3.50.1"},"reference-count":54,"publisher":"American Spinal Injury Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"\n Background:<\/jats:title>\n Individuals with spinal cord injury (SCI) at and above T6 experience impaired descending cortical control of the autonomic nervous system, which predisposes them to blood pressure (BP) disorders including persistent hypotension.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n The primary aim of this investigation was to determine the effects of midodrine, 10 mg, administered daily over a 30-day period in the home environment, compared to placebo, on laboratory assessments of BP, cerebral blood flow velocity (CBFv), and cognitive performance in hypotensive individuals with chronic SCI.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This prospective, randomized, placebo-controlled, double-blind, crossover trial was conducted in 15 individuals with tetraplegia. In the first 30-day period, five participants were randomized to midodrine and 10 were randomized to placebo; participants were then crossed over to the second 30-day period following a 14-day washout. Laboratory assessments of BP, CBFv, and cognitive performance were measured before and after each of the two study arms.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Systolic BP (SBP) was significantly increased following midodrine administration compared to placebo (116 \u00b1 23 mm Hg vs 94 \u00b1 16 mm Hg;\n p<\/jats:italic>\n = .002). In addition, diastolic CBFv was increased after midodrine administration compared to placebo (31.0 \u00b1 11.2 vs 25.6 \u00b1 9.1 cm\/s;\n p<\/jats:italic>\n = .04). However, there were no significant drug by time interaction effects for systolic or mean CBFv (\n p<\/jats:italic>\n > .172) and cognitive performance (\n p<\/jats:italic>\n = .689).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The results suggest significant increases in SBP and diastolic CBFv without appreciable effects on cognition after 30 days of midodrine administration. Further investigation is needed to identify effective antihypotensive treatment options that not only normalize BP but also improve CBFv and cognition.<\/jats:p>\n <\/jats:sec>","DOI":"10.46292\/sci23-00038","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T01:47:55Z","timestamp":1722217675000},"page":"45-56","source":"Crossref","is-referenced-by-count":0,"title":["Effects of 30-Day Midodrine Administration, Compared to Placebo, on Blood Pressure, Cerebral Blood Flow Velocity, and Cognitive Performance in Persons with SCI"],"prefix":"10.46292","volume":"30","author":[{"given":"Caitlyn G.","family":"Peters","sequence":"first","affiliation":[{"name":"James J. Peters VA Medical Center, Bronx, New York"},{"name":"Kessler Foundation, West Orange, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Weir","sequence":"additional","affiliation":[{"name":"Department of Health, Sport, and Exercise Sciences, University of Kansas, Lawrence, Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy D.","family":"Chiaravalloti","sequence":"additional","affiliation":[{"name":"Kessler Foundation, West Orange, New Jersey"},{"name":"Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor A.","family":"Dyson-Hudson","sequence":"additional","affiliation":[{"name":"Kessler Foundation, West Orange, New Jersey"},{"name":"Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"Kirshblum","sequence":"additional","affiliation":[{"name":"Kessler Foundation, West Orange, New Jersey"},{"name":"Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, New Jersey"},{"name":"Kessler Institute for Rehabilitation, West Orange, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill M.","family":"Wecht","sequence":"additional","affiliation":[{"name":"James J. Peters VA Medical Center, Bronx, New York"},{"name":"Departments of Medicine and Rehabilitation Medicine, the Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"25425","reference":[{"key":"b1","series-title":"Clin Autonom Res","first-page":"3","article-title":"Cognitive performance in hypotensive persons with spinal cord injury","volume":"20","author":"Jegede\n AB","year":"2010","unstructured":"Jegede\n AB\n , Rosado-RiveraD, BaumanWA, et al.\n Cognitive performance in hypotensive persons with spinal cord injury. Clin Autonom Res. 2010;20:3-9."},{"issue":"2","key":"b2","series-title":"J Spinal Cord Med","first-page":"74","article-title":"Decentralized cardiovascular autonomic control and cognitive deficits in persons with spinal cord injury","volume":"36","author":"Wecht\n JM","year":"2013","unstructured":"Wecht\n JM\n , BaumanWA. Decentralized cardiovascular autonomic control and cognitive deficits in persons with spinal cord injury. J Spinal Cord Med. 2013;36(2):74-81."},{"issue":"24","key":"b3","series-title":"J Neurotrauma","first-page":"2957","article-title":"Systemic and cerebral hemodynamic contribution to cognitive performance in spinal cord injury","volume":"35","author":"Wecht\n JM","year":"2018","unstructured":"Wecht\n JM\n , WeirJP, KatzelnickCG, et al.\n Systemic and cerebral hemodynamic contribution to cognitive performance in spinal cord injury. J Neurotrauma. 2018;35(24):2957-2964."},{"issue":"3","key":"b4","series-title":"Physiol Rep","article-title":"Effects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controls","volume":"4","author":"Wecht\n JM","year":"2016","unstructured":"Wecht\n JM\n , WeirJP, RadulovicM, BaumanWA. Effects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controls. Physiol Rep. 2016;4(3):e12683."},{"issue":"9","key":"b5","series-title":"Arch Phys Med Rehabil","first-page":"1721","article-title":"Impact of blood pressure dysregulation on health-related quality of life in persons with spinal cord injury: Development of a conceptual model","volume":"94","author":"Carlozzi\n NE","year":"2013","unstructured":"Carlozzi\n NE\n , FyffeD, MorinKG, et al.\n Impact of blood pressure dysregulation on health-related quality of life in persons with spinal cord injury: Development of a conceptual model. Arch Phys Med Rehabil. 2013;94(9):1721-1730."},{"key":"b6","series-title":"Clin Autonom Res","first-page":"39","article-title":"Effect of hypotensive challenge on systemic hemodynamics and cerebral blood flow in persons with tetraplegia","volume":"19","author":"Handrakis\n JP","year":"2009","unstructured":"Handrakis\n JP\n , DeMeersmanRE, Rosado-RiveraD, et al.\n Effect of hypotensive challenge on systemic hemodynamics and cerebral blood flow in persons with tetraplegia. Clin Autonom Res. 2009;19:39-45."},{"issue":"6","key":"b7","series-title":"J Physiol","first-page":"1677","article-title":"Rigid and remodelled: Cerebrovascular structure and function after experimental high-thoracic spinal cord transection","volume":"594","author":"Phillips\n A","year":"2016","unstructured":"Phillips\n A\n , MatinN, FriasB, et al.\n Rigid and remodelled: Cerebrovascular structure and function after experimental high-thoracic spinal cord transection. J Physiol. 2016;594(6):1677-1688."},{"issue":"18","key":"b8","series-title":"J Neurotrauma","first-page":"1551","article-title":"Regulation of cerebral blood flow after spinal cord injury","volume":"30","author":"Phillips\n AA","year":"2013","unstructured":"Phillips\n AA\n , AinsliePN, KrassioukovAV, WarburtonDE. Regulation of cerebral blood flow after spinal cord injury. J Neurotrauma. 2013;30(18):1551-1563."},{"key":"b9","series-title":"Meeting held in Geneva","article-title":"Arterial Hypertension: Report of a WHO Expert Committee","author":"World Health Organization","unstructured":"World Health Organization\n . Arterial Hypertension: Report of a WHO Expert Committee. Meeting held in GenevafromMarch 13-21, 1978."},{"key":"b10","series-title":"Clin Autonom Res","first-page":"49","article-title":"Orthostatic hypotension and orthostatic hypertension in American veterans","volume":"26","author":"Wecht\n JM","year":"2016","unstructured":"Wecht\n JM\n , WeirJP, MartinezS, EraifejM, BaumanWA. Orthostatic hypotension and orthostatic hypertension in American veterans. Clin Autonom Res. 2016;26:49-58."},{"issue":"5","key":"b11","series-title":"J Spinal Cord Med","first-page":"463","article-title":"A retrospective chart review of heart rate and blood pressure abnormalities in veterans with spinal cord injury","volume":"36","author":"Zhu\n C","year":"2013","unstructured":"Zhu\n C\n , GaleaM, LivoteE, SignorD, WechtJM. A retrospective chart review of heart rate and blood pressure abnormalities in veterans with spinal cord injury. J Spinal Cord Med. 2013;36(5):463-475."},{"issue":"12","key":"b12","series-title":"J Neurotrauma","first-page":"1713","article-title":"Orthostatic hypotension and autonomic pathways after spinal cord injury","volume":"23","author":"Claydon\n VE","year":"2006","unstructured":"Claydon\n VE\n , KrassioukovAV. Orthostatic hypotension and autonomic pathways after spinal cord injury. J Neurotrauma. 2006;23(12):1713-1725."},{"issue":"1","key":"b13","series-title":"Spinal Cord","first-page":"4","article-title":"Effect of tilting on the cardiovascular responses and plasma catecholamine levels in spinal man","volume":"1","author":"Guttmann\n L","year":"1963","unstructured":"Guttmann\n L\n , MunroA, RobinsonR, WalshJ. Effect of tilting on the cardiovascular responses and plasma catecholamine levels in spinal man. Spinal Cord. 1963;1(1):4-18."},{"issue":"4","key":"b14","series-title":"Clinical Sci Molec Med","first-page":"291","article-title":"Plasma catecholamines, plasma renin activity and plasma aldosterone in tetraplegic man, horizontal and tilted","volume":"49","author":"Mathias\n C","year":"1975","unstructured":"Mathias\n C\n , ChristensenN, CorbettJ, FrankelH, GoodwinT, PeartW. Plasma catecholamines, plasma renin activity and plasma aldosterone in tetraplegic man, horizontal and tilted. Clinical Sci Molec Med. 1975;49(4):291-299."},{"issue":"1","key":"b15","series-title":"Am J Physiol Heart Circ Physiol","first-page":"H190","article-title":"Direct and reflexive effects of nitric oxide synthase inhibition on blood pressure","volume":"294","author":"Wecht\n JM","year":"2008","unstructured":"Wecht\n JM\n , WeirJP, GoldsteinDS, et al.\n Direct and reflexive effects of nitric oxide synthase inhibition on blood pressure. Am J Physiol Heart Circ Physiol. 2008;294(1):H190-H197."},{"key":"b16","series-title":"Clin Autonom Res","first-page":"296","article-title":"Pyridostigmine in autonomic failure: Can we treat postural hypotension and bladder dysfunction with one drug?","volume":"16","author":"Yamamoto\n T","year":"2006","unstructured":"Yamamoto\n T\n , SakakibaraR, YamanakaY, et al.\n Pyridostigmine in autonomic failure: Can we treat postural hypotension and bladder dysfunction with one drug?\n Clin Autonom Res. 2006;16:296-298."},{"issue":"16","key":"b17","series-title":"Circulation","first-page":"2127","article-title":"Cardiovascular control during exercise: Insights from spinal cord\u2013 injured humans","volume":"107","author":"Dela\n F","year":"2003","unstructured":"Dela\n F\n , MohrT, JensenCM, et al.\n Cardiovascular control during exercise: Insights from spinal cord\u2013 injured humans. Circulation. 2003;107(16):2127-2133."},{"issue":"6","key":"b18","series-title":"Medicine Sci Sports Exerc","first-page":"913","article-title":"Effect of an abdominal binder during wheelchair exercise","volume":"27","author":"Kerk\n JK","year":"1995","unstructured":"Kerk\n JK\n , CliffordPS, SnyderA, et al.\n Effect of an abdominal binder during wheelchair exercise. Medicine Sci Sports Exerc. 1995;27(6):913-919."},{"issue":"1","key":"b19","series-title":"J Spinal Cord Med","first-page":"88","article-title":"Patterns of cognitive deficits in persons with spinal cord injury as compared with both age-matched and older individuals without spinal cord injury","volume":"43","author":"Chiaravalloti\n ND","year":"2020","unstructured":"Chiaravalloti\n ND\n , WeberE, WylieG, Dyson-HudsonT, WechtJM. Patterns of cognitive deficits in persons with spinal cord injury as compared with both age-matched and older individuals without spinal cord injury. J Spinal Cord Med. 2020;43(1):88-97."},{"issue":"5","key":"b20","series-title":"J Spinal Cord Med","first-page":"633","article-title":"The impact of level of injury on patterns of cognitive dysfunction in individuals with spinal cord injury","volume":"43","author":"Chiaravalloti\n ND","year":"2020","unstructured":"Chiaravalloti\n ND\n , WeberE, WylieG, Dyson-HudsonT, WechtJM. The impact of level of injury on patterns of cognitive dysfunction in individuals with spinal cord injury. J Spinal Cord Med. 2020;43(5):633-641."},{"issue":"6","key":"b21","series-title":"Arch Phys Med Rehabil","first-page":"1147","article-title":"Traumatic spinal cord injury and risk of early and late onset Alzheimer's disease and related dementia: Large longitudinal study","volume":"102","author":"Mahmoudi\n E","year":"2021","unstructured":"Mahmoudi\n E\n , LinP, PetersonMD, MeadeMA, TateDG, KamdarN. Traumatic spinal cord injury and risk of early and late onset Alzheimer's disease and related dementia: Large longitudinal study. Arch Phys Med Rehabil. 2021;102(6):1147-1154."},{"key":"b22","series-title":"J Spinal Cord Med","first-page":"1","article-title":"Clinical trial of home blood pressure monitoring following midodrine administration in hypotensive individuals with spinal cord injury","author":"Wecht\n JM","year":"2023","unstructured":"Wecht\n JM\n , WeirJP, KatzelnickCG, Dyson-HudsonTA, BaumanWA, KirshblumSC. Clinical trial of home blood pressure monitoring following midodrine administration in hypotensive individuals with spinal cord injury. J Spinal Cord Med. 2023:1-9."},{"issue":"9","key":"b23","series-title":"Spinal Cord","first-page":"959","article-title":"Double-blinded, placebo-controlled crossover trial to determine the effects of midodrine on blood pressure during cognitive testing in persons with SCI","volume":"58","author":"Wecht\n JM","year":"2020","unstructured":"Wecht\n JM\n , WeirJP, KatzelnickCG, et al.\n Double-blinded, placebo-controlled crossover trial to determine the effects of midodrine on blood pressure during cognitive testing in persons with SCI. Spinal Cord. 2020;58(9):959-969."},{"issue":"2","key":"b24","series-title":"J Pharmacol Pharmacotherapeut","first-page":"100","article-title":"CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials","volume":"1","author":"Schulz\n KF","year":"2010","unstructured":"Schulz\n KF\n , AltmanDG, MoherD. CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. J Pharmacol Pharmacotherapeut. 2010;1(2):100-107."},{"issue":"6","key":"b25","series-title":"J Neurotrauma","first-page":"1156","article-title":"Cognitive impairment and mood states after spinal cord injury","volume":"34","author":"Craig\n A","year":"2017","unstructured":"Craig\n A\n , GuestR, TranY, MiddletonJ. Cognitive impairment and mood states after spinal cord injury. J Neurotrauma. 2017;34(6):1156-1163."},{"issue":"4","key":"b26","series-title":"Br J Health Psychol","first-page":"807","article-title":"Adjustment following chronic spinal cord injury: Determining factors that contribute to social participation","volume":"20","author":"Craig\n A","year":"2015","unstructured":"Craig\n A\n , Nicholson PerryK, GuestR, TranY, MiddletonJ. Adjustment following chronic spinal cord injury: Determining factors that contribute to social participation. Br J Health Psychol. 2015;20(4):807-823."},{"issue":"5","key":"b27","series-title":"J Cerebr Blood Flow Metab","first-page":"794","article-title":"Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: Improved by alpha-1 agonist midodrine hydochloride","volume":"34","author":"Phillips\n AA","year":"2014","unstructured":"Phillips\n AA\n , WarburtonDE, AinsliePN, KrassioukovAV. Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: Improved by alpha-1 agonist midodrine hydochloride. J Cerebr Blood Flow Metab. 2014;34(5):794-801."},{"key":"b1","series-title":"Clin Autonom Res","first-page":"3","article-title":"Cognitive performance in hypotensive persons with spinal cord injury","volume":"20","author":"Jegede\n AB","year":"2010","unstructured":"Jegede\n AB\n , Rosado-RiveraD, BaumanWA, et al.\n Cognitive performance in hypotensive persons with spinal cord injury. Clin Autonom Res. 2010;20:3-9."},{"issue":"2","key":"b2","series-title":"J Spinal Cord Med","first-page":"74","article-title":"Decentralized cardiovascular autonomic control and cognitive deficits in persons with spinal cord injury","volume":"36","author":"Wecht\n JM","year":"2013","unstructured":"Wecht\n JM\n , BaumanWA. Decentralized cardiovascular autonomic control and cognitive deficits in persons with spinal cord injury. J Spinal Cord Med. 2013;36(2):74-81."},{"issue":"24","key":"b3","series-title":"J Neurotrauma","first-page":"2957","article-title":"Systemic and cerebral hemodynamic contribution to cognitive performance in spinal cord injury","volume":"35","author":"Wecht\n JM","year":"2018","unstructured":"Wecht\n JM\n , WeirJP, KatzelnickCG, et al.\n Systemic and cerebral hemodynamic contribution to cognitive performance in spinal cord injury. J Neurotrauma. 2018;35(24):2957-2964."},{"issue":"3","key":"b4","series-title":"Physiol Rep","article-title":"Effects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controls","volume":"4","author":"Wecht\n JM","year":"2016","unstructured":"Wecht\n JM\n , WeirJP, RadulovicM, BaumanWA. Effects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controls. Physiol Rep. 2016;4(3):e12683."},{"issue":"9","key":"b5","series-title":"Arch Phys Med Rehabil","first-page":"1721","article-title":"Impact of blood pressure dysregulation on health-related quality of life in persons with spinal cord injury: Development of a conceptual model","volume":"94","author":"Carlozzi\n NE","year":"2013","unstructured":"Carlozzi\n NE\n , FyffeD, MorinKG, et al.\n Impact of blood pressure dysregulation on health-related quality of life in persons with spinal cord injury: Development of a conceptual model. Arch Phys Med Rehabil. 2013;94(9):1721-1730."},{"key":"b6","series-title":"Clin Autonom Res","first-page":"39","article-title":"Effect of hypotensive challenge on systemic hemodynamics and cerebral blood flow in persons with tetraplegia","volume":"19","author":"Handrakis\n JP","year":"2009","unstructured":"Handrakis\n JP\n , DeMeersmanRE, Rosado-RiveraD, et al.\n Effect of hypotensive challenge on systemic hemodynamics and cerebral blood flow in persons with tetraplegia. Clin Autonom Res. 2009;19:39-45."},{"issue":"6","key":"b7","series-title":"J Physiol","first-page":"1677","article-title":"Rigid and remodelled: Cerebrovascular structure and function after experimental high-thoracic spinal cord transection","volume":"594","author":"Phillips\n A","year":"2016","unstructured":"Phillips\n A\n , MatinN, FriasB, et al.\n Rigid and remodelled: Cerebrovascular structure and function after experimental high-thoracic spinal cord transection. J Physiol. 2016;594(6):1677-1688."},{"issue":"18","key":"b8","series-title":"J Neurotrauma","first-page":"1551","article-title":"Regulation of cerebral blood flow after spinal cord injury","volume":"30","author":"Phillips\n AA","year":"2013","unstructured":"Phillips\n AA\n , AinsliePN, KrassioukovAV, WarburtonDE. Regulation of cerebral blood flow after spinal cord injury. J Neurotrauma. 2013;30(18):1551-1563."},{"key":"b9","series-title":"Meeting held in Geneva","article-title":"Arterial Hypertension: Report of a WHO Expert Committee","author":"World Health Organization","unstructured":"World Health Organization\n . Arterial Hypertension: Report of a WHO Expert Committee. Meeting held in GenevafromMarch 13-21, 1978."},{"key":"b10","series-title":"Clin Autonom Res","first-page":"49","article-title":"Orthostatic hypotension and orthostatic hypertension in American veterans","volume":"26","author":"Wecht\n JM","year":"2016","unstructured":"Wecht\n JM\n , WeirJP, MartinezS, EraifejM, BaumanWA. Orthostatic hypotension and orthostatic hypertension in American veterans. Clin Autonom Res. 2016;26:49-58."},{"issue":"5","key":"b11","series-title":"J Spinal Cord Med","first-page":"463","article-title":"A retrospective chart review of heart rate and blood pressure abnormalities in veterans with spinal cord injury","volume":"36","author":"Zhu\n C","year":"2013","unstructured":"Zhu\n C\n , GaleaM, LivoteE, SignorD, WechtJM. A retrospective chart review of heart rate and blood pressure abnormalities in veterans with spinal cord injury. J Spinal Cord Med. 2013;36(5):463-475."},{"issue":"12","key":"b12","series-title":"J Neurotrauma","first-page":"1713","article-title":"Orthostatic hypotension and autonomic pathways after spinal cord injury","volume":"23","author":"Claydon\n VE","year":"2006","unstructured":"Claydon\n VE\n , KrassioukovAV. Orthostatic hypotension and autonomic pathways after spinal cord injury. J Neurotrauma. 2006;23(12):1713-1725."},{"issue":"1","key":"b13","series-title":"Spinal Cord","first-page":"4","article-title":"Effect of tilting on the cardiovascular responses and plasma catecholamine levels in spinal man","volume":"1","author":"Guttmann\n L","year":"1963","unstructured":"Guttmann\n L\n , MunroA, RobinsonR, WalshJ. Effect of tilting on the cardiovascular responses and plasma catecholamine levels in spinal man. Spinal Cord. 1963;1(1):4-18."},{"issue":"4","key":"b14","series-title":"Clinical Sci Molec Med","first-page":"291","article-title":"Plasma catecholamines, plasma renin activity and plasma aldosterone in tetraplegic man, horizontal and tilted","volume":"49","author":"Mathias\n C","year":"1975","unstructured":"Mathias\n C\n , ChristensenN, CorbettJ, FrankelH, GoodwinT, PeartW. Plasma catecholamines, plasma renin activity and plasma aldosterone in tetraplegic man, horizontal and tilted. Clinical Sci Molec Med. 1975;49(4):291-299."},{"issue":"1","key":"b15","series-title":"Am J Physiol Heart Circ Physiol","first-page":"H190","article-title":"Direct and reflexive effects of nitric oxide synthase inhibition on blood pressure","volume":"294","author":"Wecht\n JM","year":"2008","unstructured":"Wecht\n JM\n , WeirJP, GoldsteinDS, et al.\n Direct and reflexive effects of nitric oxide synthase inhibition on blood pressure. Am J Physiol Heart Circ Physiol. 2008;294(1):H190-H197."},{"key":"b16","series-title":"Clin Autonom Res","first-page":"296","article-title":"Pyridostigmine in autonomic failure: Can we treat postural hypotension and bladder dysfunction with one drug?","volume":"16","author":"Yamamoto\n T","year":"2006","unstructured":"Yamamoto\n T\n , SakakibaraR, YamanakaY, et al.\n Pyridostigmine in autonomic failure: Can we treat postural hypotension and bladder dysfunction with one drug?\n Clin Autonom Res. 2006;16:296-298."},{"issue":"16","key":"b17","series-title":"Circulation","first-page":"2127","article-title":"Cardiovascular control during exercise: Insights from spinal cord\u2013 injured humans","volume":"107","author":"Dela\n F","year":"2003","unstructured":"Dela\n F\n , MohrT, JensenCM, et al.\n Cardiovascular control during exercise: Insights from spinal cord\u2013 injured humans. Circulation. 2003;107(16):2127-2133."},{"issue":"6","key":"b18","series-title":"Medicine Sci Sports Exerc","first-page":"913","article-title":"Effect of an abdominal binder during wheelchair exercise","volume":"27","author":"Kerk\n JK","year":"1995","unstructured":"Kerk\n JK\n , CliffordPS, SnyderA, et al.\n Effect of an abdominal binder during wheelchair exercise. Medicine Sci Sports Exerc. 1995;27(6):913-919."},{"issue":"1","key":"b19","series-title":"J Spinal Cord Med","first-page":"88","article-title":"Patterns of cognitive deficits in persons with spinal cord injury as compared with both age-matched and older individuals without spinal cord injury","volume":"43","author":"Chiaravalloti\n ND","year":"2020","unstructured":"Chiaravalloti\n ND\n , WeberE, WylieG, Dyson-HudsonT, WechtJM. Patterns of cognitive deficits in persons with spinal cord injury as compared with both age-matched and older individuals without spinal cord injury. J Spinal Cord Med. 2020;43(1):88-97."},{"issue":"5","key":"b20","series-title":"J Spinal Cord Med","first-page":"633","article-title":"The impact of level of injury on patterns of cognitive dysfunction in individuals with spinal cord injury","volume":"43","author":"Chiaravalloti\n ND","year":"2020","unstructured":"Chiaravalloti\n ND\n , WeberE, WylieG, Dyson-HudsonT, WechtJM. The impact of level of injury on patterns of cognitive dysfunction in individuals with spinal cord injury. J Spinal Cord Med. 2020;43(5):633-641."},{"issue":"6","key":"b21","series-title":"Arch Phys Med Rehabil","first-page":"1147","article-title":"Traumatic spinal cord injury and risk of early and late onset Alzheimer's disease and related dementia: Large longitudinal study","volume":"102","author":"Mahmoudi\n E","year":"2021","unstructured":"Mahmoudi\n E\n , LinP, PetersonMD, MeadeMA, TateDG, KamdarN. Traumatic spinal cord injury and risk of early and late onset Alzheimer's disease and related dementia: Large longitudinal study. Arch Phys Med Rehabil. 2021;102(6):1147-1154."},{"key":"b22","series-title":"J Spinal Cord Med","first-page":"1","article-title":"Clinical trial of home blood pressure monitoring following midodrine administration in hypotensive individuals with spinal cord injury","author":"Wecht\n JM","year":"2023","unstructured":"Wecht\n JM\n , WeirJP, KatzelnickCG, Dyson-HudsonTA, BaumanWA, KirshblumSC. Clinical trial of home blood pressure monitoring following midodrine administration in hypotensive individuals with spinal cord injury. J Spinal Cord Med. 2023:1-9."},{"issue":"9","key":"b23","series-title":"Spinal Cord","first-page":"959","article-title":"Double-blinded, placebo-controlled crossover trial to determine the effects of midodrine on blood pressure during cognitive testing in persons with SCI","volume":"58","author":"Wecht\n JM","year":"2020","unstructured":"Wecht\n JM\n , WeirJP, KatzelnickCG, et al.\n Double-blinded, placebo-controlled crossover trial to determine the effects of midodrine on blood pressure during cognitive testing in persons with SCI. Spinal Cord. 2020;58(9):959-969."},{"issue":"2","key":"b24","series-title":"J Pharmacol Pharmacotherapeut","first-page":"100","article-title":"CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials","volume":"1","author":"Schulz\n KF","year":"2010","unstructured":"Schulz\n KF\n , AltmanDG, MoherD. CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. 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