{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:51:10Z","timestamp":1775148670873,"version":"3.50.1"},"reference-count":58,"publisher":"American Spinal Injury Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"\n Background:<\/jats:title>\n The risk of symptomatic urinary tract infections (UTIs) after spinal cord injury\/disease (SCI\/D) is increased, and effective preventive measures are lacking.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n To evaluate the feasibility of a full-size trial on the efficacy of oral immunomodulation for the primary prevention of symptomatic UTIs in patients with SCI\/D.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n This was a randomized, placebo-controlled, quasi-blinded, monocentric feasibility trial enrolling patients with SCI\/D during primary in-house rehabilitation. Participants received either a lyophilized\n Escherichia coli<\/jats:italic>\n lysate (Uro-Vaxom\u00ae) or placebo for 90 days. During the intervention and a 3-month follow-up period, symptomatic UTIs and side effects were recorded. Upon trial completion, participants were asked to rate their trial experience.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A total of 446 individuals with acute SCI\/D were screened. Twenty-four out of 83 eligible candidates (28.9%) provided written informed consent, while 22 (26.5%) were randomized. The retention rate was high (90.9%) in both groups. Data of seven women and 13 men (40.8 \u00b1 12.8 years) were analyzed. In the Uro-Vaxom group, two participants did not complete the treatment (adherence rate 80%). Six participants receiving Uro-Vaxom experienced symptomatic UTIs compared to nine participants in the placebo group. Six and four participants reported side effects in the Uro-Vaxom and placebo groups, respectively. Eighteen participants expressed willingness to participate again in a similar future trial.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The trial demonstrated strong retention and adherence rates with minimal participant burden. Consideration of broader inclusion criteria is suggested to improve the number of eligible patients and enhance participant recruitment.<\/jats:p>\n <\/jats:sec>","DOI":"10.46292\/sci24-00045","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T03:56:15Z","timestamp":1745985375000},"page":"130-140","source":"Crossref","is-referenced-by-count":0,"title":["Immunomodulation for Primary Prevention of Urinary Tract Infections in Patients With Spinal Cord Injury or Disease During Primary In-House Rehabilitation: Results From a Randomized Placebo-Controlled Feasibility Trial (UroVaxom-Pilot)"],"prefix":"10.46292","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1807-2670","authenticated-orcid":true,"given":"J\u00f6rg","family":"Krebs","sequence":"first","affiliation":[{"name":"Swiss Paraplegic Research, Nottwil, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"W\u00f6llner","sequence":"additional","affiliation":[{"name":"Swiss Paraplegic Research, Nottwil, Switzerland"},{"name":"Neuro-Urology, Swiss Paraplegic Centre, Nottwil, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Neuenschwander","sequence":"additional","affiliation":[{"name":"Neuro-Urology, Swiss Paraplegic Centre, Nottwil, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Mahler","sequence":"additional","affiliation":[{"name":"Swiss Paraplegic Research, Nottwil, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezra","family":"Valido","sequence":"additional","affiliation":[{"name":"Swiss Paraplegic Research, Nottwil, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Harder","sequence":"additional","affiliation":[{"name":"Paraplegiology, Swiss Paraplegic Centre, Nottwil, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jivko","family":"Stoyanov","sequence":"additional","affiliation":[{"name":"Swiss Paraplegic Research, Nottwil, Switzerland"},{"name":"Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Pannek","sequence":"additional","affiliation":[{"name":"Swiss Paraplegic Research, Nottwil, Switzerland"},{"name":"Neuro-Urology, Swiss Paraplegic Centre, Nottwil, Switzerland"},{"name":"Department of Urology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"25425","reference":[{"issue":"9","key":"b1","series-title":"Curr Urol Rep","first-page":"433","article-title":"UTIs in patients with neurogenic bladder","volume":"15","author":"Jahromi MS","year":"2014","unstructured":"Jahromi MS, Mure A, Gomez CS. 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