{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:49:55Z","timestamp":1782863395689,"version":"3.54.5"},"reference-count":68,"publisher":"American Spinal Injury Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Transcutaneous spinal cord stimulation (tSCS) has shown evidence of leveraging intact neural circuits to increase blood pressure (BP) in hypotensive people with chronic spinal cord injury (SCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The primary aim is to determine the safety and feasibility of using tSCS to promote seated systolic BP (SBP) within a target range of 110-130 mm Hg and to mitigate the fall in BP with transition to an upright position in hypotensive participants during acute inpatient rehabilitation (AIR) following SCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/Methods:<\/jats:title>\n                    <jats:p>Cathode placement on the spine will be randomized among 4 sites: T7\/8, T9\/10, T11\/12, and L1\/2. Mapping for other stimulation parameters includes waveform (monophasic, biphasic, pseudo-monophasic), frequency (30, 60, 120 Hz), use of a carrier frequency (0, 10 kHz), and stimulation amplitude (0-100 mA). Each mapping session will consist of 2 sit-up tests, one without stimulation followed by one with stimulation. During the sit-up test with stimulation, intensity will be slowly increased to 30 mA with continuous monitoring of BP, heart rate, pain, and symptoms of orthostatic hypotension (OH) and autonomic dysreflexia (AD). Once 30 mA is reached, brachial BP will be monitored for 5 minutes. If below the target SBP range, stimulation intensity will be increased in increments of 5 to 10 mA until one of the following occurs: (1) SBP is within the target range, (2) stimulation is intolerable, (3) 100 mA is reached, or (4) stimulation is delivered for 30 minutes. Safety and feasibility will be measured by assessing burn frequency, pain level, and symptoms of AD and OH along with scheduling compliance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.46292\/sci25-00028","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T12:09:57Z","timestamp":1756728597000},"page":"12-20","source":"Crossref","is-referenced-by-count":1,"title":["Protocol for Safety, Feasibility, and Efficacy of Using Targeted Transcutaneous Spinal Cord Stimulation to Treat Hypotension During Acute Inpatient Rehabilitation in Individuals With SCI"],"prefix":"10.46292","volume":"32","author":[{"given":"Jorge","family":"Chavez","sequence":"first","affiliation":[{"name":"Spinal Cord Damage Research Center, James J Peters VA Medical Center, Bronx, New York"},{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve L.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Spinal Cord Damage Research Center, James J Peters VA Medical Center, Bronx, New York"},{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Weir","sequence":"additional","affiliation":[{"name":"Department of Health, Sport, and Exercise Sciences, University of Kansas, Lawrence, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Ying","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn E.","family":"Fox","sequence":"additional","affiliation":[{"name":"Spinal Cord Damage Research Center, James J Peters VA Medical Center, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam Y.","family":"Harel","sequence":"additional","affiliation":[{"name":"Spinal Cord Damage Research Center, James J Peters VA Medical Center, Bronx, New York"},{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda M.","family":"Murray","sequence":"additional","affiliation":[{"name":"Spinal Cord Damage Research Center, James J Peters VA Medical Center, Bronx, New York"},{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob A.","family":"Goldsmith","sequence":"additional","affiliation":[{"name":"Spinal Cord Damage Research Center, James J Peters VA Medical Center, Bronx, New York"},{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Sutor","sequence":"additional","affiliation":[{"name":"Spinal Cord Damage Research Center, James J Peters VA Medical Center, Bronx, New York"},{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel X.","family":"Escalon","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas N.","family":"Bryce","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill M.","family":"Wecht","sequence":"additional","affiliation":[{"name":"Spinal Cord Damage Research Center, James J Peters VA Medical Center, Bronx, New York"},{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25425","reference":[{"key":"b1","series-title":"Seminars in Neurology","first-page":"550559","article-title":"Cardiovascular autonomic dysfunction in spinal cord injury: epidemiology, diagnosis, and management","author":"Wecht JM","year":"2020","unstructured":"Wecht JM, Harel NY, Guest J, et al. Cardiovascular autonomic dysfunction in spinal cord injury: epidemiology, diagnosis, and management. In: Seminars in Neurology. Thieme Medical Publishers; 2020: 550559."},{"key":"b2","series-title":"Resuscitation","first-page":"5762","article-title":"The incidence of neurogenic shock in patients with isolated spinal cord injury in the emergency department","volume":"76","author":"Guly H","year":"2008","unstructured":"Guly H, Bouamra O, Lecky F. The incidence of neurogenic shock in patients with isolated spinal cord injury in the emergency department. Resuscitation. 2008;76:5762."},{"key":"b3","series-title":"Am Surg","first-page":"623626","article-title":"The incidence of neurogenic shock after spinal cord injury in patients admitted to a highvolume level I trauma center","volume":"78","author":"Mallek JT","year":"2012","unstructured":"Mallek JT, Inaba K, Branco BC, et al. The incidence of neurogenic shock after spinal cord injury in patients admitted to a highvolume level I trauma center. Am Surg. 2012;78:623626."},{"key":"b4","series-title":"J Neurotrauma","first-page":"461466","article-title":"Incidence and natural progression of neurogenic shock after traumatic spinal cord injury","volume":"35","author":"Ruiz IA","year":"2018","unstructured":"Ruiz IA, Squair JW, Phillips AA, et al. Incidence and natural progression of neurogenic shock after traumatic spinal cord injury. J Neurotrauma. 2018;35:461466."},{"key":"b5","series-title":"Clin Autonom Res","first-page":"335337","article-title":"A walking disaster: A case of incomplete spinal cord injury with symptomatic orthostatic hypotension","volume":"25","author":"Currie KD","year":"2015","unstructured":"Currie KD, Krassioukov AV. A walking disaster: A case of incomplete spinal cord injury with symptomatic orthostatic hypotension. 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