{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T03:02:38Z","timestamp":1779850958734,"version":"3.53.1"},"reference-count":82,"publisher":"American Spinal Injury Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background:<\/jats:title>\n Spinal cord injury (SCI) causes major functional limitations. The subacute phase offers a critical window to optimize recovery. High-intensity interval training (HIIT) may improve cardiorespiratory fitness (CRF) in chronic complete SCI, but evidence in subacute incomplete SCI is limited.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n To evaluate the effects of 6 weeks of HIIT on CRF compared with usual care in subacute motor incomplete SCI.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n In this explorative randomized controlled trial, participants with subacute incomplete SCI were assigned to HIIT or usual care. HIIT involved 2 to 3 weekly arm-ergometry sessions. Usual care consisted of individualized inpatient rehabilitation fitness, mainly focusing on strength training. Primary outcomes were relative peak oxygen uptake (VO\n 2<\/jats:sub>\n peak) and absolute peak power output (PPO), measured by cardiopulmonary exercise testing. Pre-post changes across all participants were analyzed with the Wilcoxon signed-rank test and between-group differences with the Mann-Whitney\n U<\/jats:italic>\n test.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of 19 randomized participants, 7\/10 completed HIIT (70%), and all 9 completed usual care (100%). Across groups, relative VO\n 2<\/jats:sub>\n peak increased from 18.0 (12.5-23.7) to 20.3 (14.4-24.8) mL\/kg\/min and absolute PPO increased from 63 (35-75) to 73 (45-85) watts post intervention (both\n P<\/jats:italic>\n S<\/jats:sub>\n = .003), with no between-group differences. A higher proportion of HIIT participants (57%) achieved clinically meaningful VO\n 2<\/jats:sub>\n peak improvements compared with usual care (33%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Inpatient rehabilitation, through HIIT or usual care, improved CRF in individuals with subacute motor incomplete SCI. Although between-group differences were not found, a greater proportion of HIIT participants achieved clinically meaningful CRF improvements, suggesting that HIIT may improve CRF in this population.<\/jats:p>\n <\/jats:sec>","DOI":"10.46292\/sci25-00101","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T02:20:17Z","timestamp":1779848417000},"page":"96-109","source":"Crossref","is-referenced-by-count":0,"title":["High-Intensity Interval Training in Individuals with Subacute Motor Incomplete Spinal Cord Injury: An Explorative Randomized Controlled Trial"],"prefix":"10.46292","volume":"32","author":[{"given":"Maxime J.","family":"van Oort","sequence":"first","affiliation":[{"name":"Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"Department of Research and Innovation, Sint Maartenskliniek, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse J. W.","family":"van Nes","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Sint Maartenskliniek, Nijmegen, the Netherlands"},{"name":"Department of Rehabilitation Medicine, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick H. J.","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise M.","family":"Wilders","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Sint Maartenskliniek, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T. E.","family":"Hopman","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelleke G.","family":"Langerak","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"Department of Research and Innovation, Sint Maartenskliniek, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25425","reference":[{"key":"b1","series-title":"Handboek dwarslaesierevalidatie (3e herziene druk)","author":"Van Asbeck FWA","year":"2016","unstructured":"Van Asbeck FWA, Van Nes IJW. Handboek dwarslaesierevalidatie (3e herziene druk). 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