{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:52:36Z","timestamp":1791453156511,"version":"4.3.3"},"reference-count":15,"publisher":"American Spinal Injury Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Neuropathic pain after spinal cord injury (SCI) is common and often refractory to treatment. Scrambler Therapy (ST) is a noninvasive neuromodulation approach that delivers synthetic \u201cnonpain\u201d signals via cutaneous electrodes. We report 2 cases of SCI-related neuropathic pain treated with ST. One patient experienced transient and inconsistent relief, while the other achieved substantial, durable improvement with functional recovery and complete response after retreatment. ST was well tolerated with minimal adverse effects. These cases highlight variable response and support further study of ST as a potential treatment for refractory SCI-related neuropathic pain.<\/jats:p>","DOI":"10.46292\/sci25-00143","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:23:23Z","timestamp":1791451403000},"page":"137-140","source":"Crossref","is-referenced-by-count":0,"title":["Scrambler Therapy for Neuropathic Pain After Spinal Cord Injury: Two Case Reports"],"prefix":"10.46292","volume":"32","author":[{"given":"Zhu","family":"Wang","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, Section of Palliative Medicine, Department of Medicine, Johns Hopkins Medical School, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippines","family":"Cabahug","sequence":"additional","affiliation":[{"name":"Kennedy Krieger Institute, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Institute, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25425","reference":[{"issue":"2","key":"b1","series-title":"Spinal Cord","first-page":"63","article-title":"Pain following spinal cord injury","volume":"39","author":"Siddall PJ","year":"2001","unstructured":"Siddall PJ, Loeser JD. Pain following spinal cord injury. Spinal Cord. 2001;39(2):63\u201373."},{"issue":"2","key":"b2","series-title":"Eur J Neurol","first-page":"73","article-title":"Spinal cord injury pain\u2014mechanisms and treatment","volume":"11","author":"Finnerup NB","year":"2004","unstructured":"Finnerup NB, Jensen TS. Spinal cord injury pain\u2014mechanisms and treatment. Eur J Neurol. 2004;11(2):73\u201382."},{"issue":"10","key":"b3","series-title":"Spinal Cord","first-page":"809","article-title":"The International Spinal Cord Injury Pain Classification, version 2.0","volume":"54","author":"Widerstr\u00f6m-Noga E","year":"2016","unstructured":"Widerstr\u00f6m-Noga E, Biering-S\u00f8rensen F, et al. The International Spinal Cord Injury Pain Classification, version 2.0. Spinal Cord. 2016;54(10):809\u2013814."},{"issue":"2","key":"b4","series-title":"Lancet Neurol","first-page":"162","article-title":"Pharmacotherapy for neuropathic pain in adults: systematic review and meta-analysis","volume":"14","author":"Finnerup NB","year":"2015","unstructured":"Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162\u2013173."},{"issue":"1","key":"b5","series-title":"Top Spinal Cord Inj Rehabil","first-page":"24","article-title":"Pain post spinal cord injury: A review","volume":"16","author":"Mehta S","year":"2010","unstructured":"Mehta S, Teasell RW, Loh E, et al. Pain post spinal cord injury: A review. Top Spinal Cord Inj Rehabil. 2010;16(1):24\u201336."},{"issue":"9","key":"b6","series-title":"Spinal Cord","first-page":"640","article-title":"Psychological morbidity and chronic pain in SCI","volume":"53","author":"Craig A","year":"2015","unstructured":"Craig A, Tran Y, Siddall P, et al. Psychological morbidity and chronic pain in SCI. Spinal Cord. 2015;53(9):640\u2013644."},{"issue":"6","key":"b7","series-title":"Neuromodulation","first-page":"515","article-title":"The appropriate use of neurostimulation in the treatment of chronic pain","volume":"17","author":"Deer TR","year":"2014","unstructured":"Deer TR, Mekhail N, Provenzano D, et al. The appropriate use of neurostimulation in the treatment of chronic pain. Neuromodulation. 2014;17(6):515\u2013550."},{"issue":"2","key":"b8","series-title":"N Engl J Med","first-page":"158","article-title":"Cutaneous electroanalgesia for relief of chronic and neuropathic pain","volume":"389","author":"Smith TJ","year":"2023","unstructured":"Smith TJ, Wang EJ, Loprinzi CL. Cutaneous electroanalgesia for relief of chronic and neuropathic pain. N Engl J Med. 2023;389(2):158\u2013164. doi: 10.1056\/NEJMra2110098."},{"key":"b9","series-title":"510(k) Premarket Notification: Scrambler Therapy Device","author":"US Food and Drug Administration","year":"2009","unstructured":"US Food and Drug Administration. 510(k) Premarket Notification: Scrambler Therapy Device. FDA; 2009."},{"issue":"1","key":"b10","series-title":"J Pain Symptom Manage","first-page":"87","article-title":"Untreatable pain resulting from chemotherapy: Scrambler Therapy mechanism and analgesic efficacy","volume":"43","author":"Marineo G","year":"2012","unstructured":"Marineo G. Untreatable pain resulting from chemotherapy: Scrambler Therapy mechanism and analgesic efficacy. J Pain Symptom Manage. 2012;43(1):87\u201395."},{"issue":"5","key":"b11","series-title":"J Support Oncol","first-page":"225","article-title":"Scrambler Therapy for chronic pain","volume":"9","author":"Smith TJ","year":"2011","unstructured":"Smith TJ, Marineo G. Scrambler Therapy for chronic pain. J Support Oncol. 2011;9(5):225\u2013230."},{"issue":"7","key":"b12","series-title":"Pain Med","first-page":"1362","article-title":"Scrambler Therapy and central sensitization","volume":"20","author":"Ricci M","year":"2019","unstructured":"Ricci M, Fofi L, Saltari R, et al. Scrambler Therapy and central sensitization. Pain Med. 2019;20(7):1362\u20131369."},{"issue":"7","key":"b13","series-title":"Pain Med","first-page":"1342","article-title":"Scrambler Therapy alters regional cerebral blood flow","volume":"16","author":"Pachman DR","year":"2015","unstructured":"Pachman DR, Weisbrod A, et al. Scrambler Therapy alters regional cerebral blood flow. Pain Med. 2015;16(7):1342\u20131349."},{"issue":"7","key":"b14","series-title":"Pain Pract","first-page":"595","article-title":"Reduction of inflammatory neuropeptides with Scrambler Therapy","volume":"15","author":"Sabato AF","year":"2015","unstructured":"Sabato AF, Marineo G, et al. Reduction of inflammatory neuropeptides with Scrambler Therapy. Pain Pract. 2015;15(7):595\u2013603."},{"issue":"1","key":"b15","series-title":"Res Nurs Health","first-page":"29","article-title":"Decreased low back pain intensity and differential gene expression following Calmare\u00ae: results from a double-blinded randomized sham-controlled study","volume":"38","author":"Starkweather AR","year":"2015","unstructured":"Starkweather AR, Coyne P, Lyon DE, et al. Decreased low back pain intensity and differential gene expression following Calmare\u00ae: results from a double-blinded randomized sham-controlled study. Res Nurs Health. 2015;38(1):29\u201338. doi: 10.1002\/nur.21632."}],"container-title":["Topics in Spinal Cord Injury Rehabilitation"],"original-title":[],"link":[{"URL":"https:\/\/tscir.kglmeridian.com\/view\/journals\/tscr\/32\/4\/article-p137.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/tscir.kglmeridian.com\/downloadpdf\/journals\/tscr\/32\/4\/article-p137.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/tscir.kglmeridian.com\/downloadpdf\/journals\/tscr\/32\/4\/article-p137.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:23:23Z","timestamp":1791451403000},"score":1,"resource":{"primary":{"URL":"https:\/\/tscir.kglmeridian.com\/view\/journals\/tscr\/32\/4\/article-p137.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":15,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.46292\/sci25-00143","relation":{},"ISSN":["1082-0744","1945-5763"],"issn-type":[{"value":"1082-0744","type":"print"},{"value":"1945-5763","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}