{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:24:07Z","timestamp":1783113847626,"version":"3.54.6"},"reference-count":0,"publisher":"Probiologists Limited","issue":"1","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/probiologists.com\/Policies"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Signal"],"abstract":"<jats:p>An investigation of comprehensive changes and shared dysregulated signaling pathways across acne patients in the early stages remains largely unexplored. In our recently published paper entitled \u201cAnalysis of Intracellular Communication Reveals Consistent Gene Changes Associated with Early-Stage Acne Skin,\u201d we utilized single-cell RNA sequencing and spatial RNA-seq datasets from acne patients to analyze cell communication. We identified dysregulated genes associated with inflammatory responses and hyperkeratinization. This commentary discusses new potential markers in major skin cell types, including endothelial cells, fibroblasts, lymphocytes, myeloid cells, keratinocytes, and smooth muscle cells. We also discuss key dysregulated genes associated with inflammation and hyperkeratinization in acne lesions, focusing on the intricate interplay between these processes. Based on our findings, we discussed potential FDA-approved treatments targeting two key pathways involved in acne pathogenesis. These insights offer new therapeutic targets for acne treatment.<\/jats:p>","DOI":"10.46439\/signaling.3.053","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T08:23:43Z","timestamp":1739262223000},"page":"32-39","source":"Crossref","is-referenced-by-count":2,"title":["Insights into early acne pathogenesis: Exploring intercellular dynamics and key dysregulated genes"],"prefix":"10.46439","volume":"3","author":[{"given":"Min","family":"Deng","sequence":"first","affiliation":[{"name":"Division of Dermatology, David Geffen School of Medicine, University of California (UCLA), Los Angeles, CA-90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiana","family":"Farahani","sequence":"additional","affiliation":[{"name":"Division of Dermatology, David Geffen School of Medicine, University of California (UCLA), Los Angeles, CA-90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Agak","sequence":"additional","affiliation":[{"name":"Division of Dermatology, David Geffen School of Medicine, University of California (UCLA), Los Angeles, CA-90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25620","published-online":{"date-parts":[[2025,2,11]]},"container-title":["Cell Signaling"],"original-title":[],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:00:33Z","timestamp":1740135633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probiologists.com\/article\/insights-into-early-acne-pathogenesis-exploring-intercellular-dynamics-and-key-dysregulated-genes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,11]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2,11]]}},"URL":"https:\/\/doi.org\/10.46439\/signaling.3.053","relation":{},"ISSN":["2837-8253"],"issn-type":[{"value":"2837-8253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,11]]}}}