{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:38:29Z","timestamp":1785530309126,"version":"3.56.0"},"reference-count":68,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"2","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Rheumatology"],"abstract":"<jats:p>Objectives: In this study, we aimed to assess the impact of serum vitamin D level in systemic lupus erythematosus (SLE) patients with novel coronavirus-2019 (COVID-19) disease on severity of infection, duration of COVID-19 disease course, and fatigue development as a complication of both SLE and COVID-19.\r\nPatients and methods: Between April 2020 and January 2021, a total of 38 patients (31 males, 7 females; mean age: 49.2\u00b18.1 years; range, 38 to 65 years) who were previously diagnosed with SLE and on different lines of lupus management were included. The patients presented to chest outpatient clinic and emergency hospital with manifestations suggesting COVID-19 infection. Vitamin D levels were measured in serum by enzymelinked immunosorbent assay (ELISA). Vitamin D supplement was added to treatment protocols for COVID-19.\r\nResults: Thirteen (34.2%) patients had normal baseline serum vitamin D levels (\u226530 ng\/mL), nine (23.7%) patients had vitamin D insufficiency (21 to 29 ng\/mL), and 16 (42.1%) patients had vitamin D deficiency (\u226420 ng\/mL). Low vitamin D levels (insufficiency &amp; deficiency) patients had long SLE disease duration (p=0.06). Also, there was a significant long time spent until recovery from COVID-19 infection in low vitamin D levels (insufficiency &amp; deficiency) patient groups versus those with normal vitamin D (p=0.019). Low baseline vitamin D level patients mainly presented with severe COVID19 symptoms (p=0.04). Patients recovered from COVID-19 had normal vitamin D levels than those who died or were lost to follow-up (p=0.07). After recovery from COVID-19, fatigue was more common in SLE patients with low baseline vitamin D level.\r\nConclusion: Vitamin D seems to play a certain role in the management of COVID-19 infection in SLE patients. Patients with normal vitamin D levels have less severe symptoms, shorter time to recovery, improved COVID-19 outcomes, and less development of fatigue after COVID-19 infection.<\/jats:p>","DOI":"10.46497\/archrheumatol.2022.8996","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:05:33Z","timestamp":1646485533000},"page":"288-299","source":"Crossref","is-referenced-by-count":7,"title":["Impact of vitamin D level and supplementation on systemic lupus erythematosus patients during COVID-19 pandemic"],"prefix":"10.5152","volume":"37","author":[{"family":"Yasmin Adel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Mohamed Elgamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sherehan Adel Abdelsalam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"ref-1","unstructured":"Jump RL, Robinson ME, Armstrong AE, Barnes EV, Kilbourn KM, Richards HB. 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