{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:41:18Z","timestamp":1790631678587,"version":"4.1.0"},"reference-count":21,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"3","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Rheumatology"],"abstract":"<jats:p>Objectives: This study was implemented to reveal the expression and the clinical correlation of matrix metalloproteinases (MPSs) with connective tissue disease (CTD) complicated with interstitial lung disease (ILD).\r\nPatients and methods: This clinical study was conducted with 260 patients (151 males, 109 females; mean age: 47.3\u00b112.5 years; range, 29 to 67 years) between October 2019 and October 2020. Among the subjects, 100 were CTD patients (CTD group), 80 were CTD patients with ILD (CTD-ILD group) and 80 were healthy individuals (control group). The MMP-2, -3, -7, and -9 levels in the serum of the three groups were detected by enzyme-linked immunosorbent assay.\r\nResults: Serum levels of MMP-3, -7, and -9 in the CTD-ILD group were higher, while the MMP-2 level was lower than those in the CTD group and the control group. The MMP-7 level in the serum of the CTD-ILD group was positively related to C-reactive protein, erythrocyte sedimentation rate, and rheumatoid factor and negatively correlated with immunoglobulin G and complement 3. The MMP-7 expression in the serum was positively correlated with forced expiratory volume in one second (FEV1%), FEV1\/forced expiratory volume (FVC), and FVC in CTD-ILD patients. Pearson statistical analysis revealed that there was a significant positive correlation between the MMP-7 expression and the percentage of B cells in the serum of CTD-ILD patients.\r\nConclusion: Expressions of MMP-3, -7, and -9 are significantly increased in the serum of patients with CTD and related interstitial lung lesions, and the high expression of MMP-7 indicates dynamic lung lesions, which is possible to be used as a possible biomarker for early diagnosis and assessment of disease progression.<\/jats:p>","DOI":"10.46497\/archrheumatol.2023.9547","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T07:04:24Z","timestamp":1675235064000},"page":"367-374","source":"Crossref","is-referenced-by-count":6,"title":["Clinical association study on the matrix metalloproteinase expression in the serum of patients with connective tissue disease complicated with interstitial lung disease"],"prefix":"10.5152","volume":"38","author":[{"family":"Hong Chen*","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Jun Tang*","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Juhua Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Dan Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Chunfeng Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sha Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Xiuri Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Liju Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Giaj-Levra N, Sciascia S, Fiorentino A, Fersino S, Mazzola R, Ricchetti F, et al. Radiotherapy in patients with connective tissue diseases. Lancet Oncol 2016;17:e109-e117.","DOI":"10.1016\/S1470-2045(15)00417-9"},{"key":"ref-2","unstructured":"Guo J, Luo F. Clinical and etiological characteristics of pulmonary infection in patients with connective tissue disease-related interstitial lung disease. Int J Respiration 2020;40:1609-15."},{"key":"ref-3","unstructured":"Li HL, Xiong Z, Liu JK, LI YS, Zhou B. High resolution CT findings of connective tissue diseaseassociated lung interstitial lesions. Journal of Central South University: Medical Science 2017;42:72-7."},{"key":"ref-4","unstructured":"Zheng XJ, Wang XX, Ruan HL, Yang JL Zhao Ya J. Research progress of rheumatoid arthritis complicated with pulmonary interstitial disease. Hebei Med J 2016;38:1708-10."},{"key":"ref-5","unstructured":"Yang SQ, Yang DL, Liu J. Role of matrix metalloproteinases-2 and matrix metalloproteinases-9 in the development and progression of chronic liver diseases. 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Respirology 2017;22:486-93.","DOI":"10.1111\/resp.12920"},{"key":"ref-9","doi-asserted-by":"crossref","unstructured":"Song JW, Do KH, Jang SJ, Colby TV, Han S, Kim DS. Blood biomarkers MMP-7 and SP-A: Predictors of outcome in idiopathic pulmonary fibrosis. Chest 2013;143:1422-9.","DOI":"10.1378\/chest.11-2735"},{"key":"ref-10","doi-asserted-by":"crossref","unstructured":"Wu Z, He D, Zhao S, Wang H. IL-17A\/IL-17RA promotes invasion and activates MMP-2 and MMP-9 expression via p38 MAPK signaling pathway in non-small cell lung cancer. Mol Cell Biochem 2019;455:195-206.","DOI":"10.1007\/s11010-018-3483-9"},{"key":"ref-11","doi-asserted-by":"crossref","unstructured":"Agraval H, Yadav UCS. MMP-2 and MMP-9 mediate cigarette smoke extract-induced epithelialmesenchymal transition in airway epithelial cells via EGFR\/Akt\/GSK3b\/b-catenin pathway: Amelioration by fisetin. Chem Biol Interact 2019;314:108846.","DOI":"10.1016\/j.cbi.2019.108846"},{"key":"ref-12","unstructured":"Song N, Duan L. Interpretation of 2015 ATS\/ ERS\/JRS\/ALAT guidelines for idiopathic pulmonary interstitial fibrosis. Clin Focus 2015;9:1073-80."},{"key":"ref-13","doi-asserted-by":"crossref","unstructured":"Xie W, Yang X, Zhang Z. The plight and light of treating rheumatoid arthritis in China. The Lancet Rheumatology 2019;1:e81-e82.","DOI":"10.1016\/S2665-9913(19)30039-6"},{"key":"ref-14","doi-asserted-by":"crossref","unstructured":"Song X, Zhang Y, Dai E, Du H, Wang L. Mechanism of action of celastrol against rheumatoid arthritis: A network pharmacology analysis. Int Immunopharmacol 2019;74:105725.","DOI":"10.1016\/j.intimp.2019.105725"},{"key":"ref-15","unstructured":"Huang H, Jin YL, Ding F. Progress in diagnosis and treatment of interstitial lung disease associated with connective tissue diseases in children. Int J Pediatrics 2020;47:768-72."},{"key":"ref-16","doi-asserted-by":"crossref","unstructured":"Tuncer T, Kaya A, Gulkesen A, Kal GA, Kaman D, Akgol G. 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Knockout of MMP3 weakens solid tumor organoids and cancer extracellular vesicles. Cancers (Basel) 2020;12:1260.","DOI":"10.3390\/cancers12051260"},{"key":"ref-20","unstructured":"Ma J, Wang X, Mo Y, Chen L, Zheng D, Wei X, et al. Value of serum matrix metalloproteinase-3 in the assessment of active disease in patients with rheumatoid arthritis. Zhonghua Yi Xue Za Zhi 2015;95:3823-8."},{"key":"ref-21","unstructured":"Xiang M. The role of mMP-7 in pulmonary fibrosis. Clin J Pulmonary Med 2013;18:525-52."}],"container-title":["Archives of Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1353\/2398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1353\/2399","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1353\/2398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T09:02:54Z","timestamp":1761210174000},"score":1,"resource":{"primary":{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/view\/1353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,30]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9,30]]}},"URL":"https:\/\/doi.org\/10.46497\/archrheumatol.2023.9547","relation":{},"ISSN":["2618-6500"],"issn-type":[{"value":"2618-6500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,30]]}}}