{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:14:42Z","timestamp":1788887682063,"version":"build-2803163510"},"reference-count":23,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"2","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Rheumatology"],"abstract":"<jats:p>Objectives: The aim of this study was to examine the clinical and phenotypic features of pediatric Beh\u00e7et\u2019s disease (PEDBD) in our clinic and present the rates of fulfilling the diagnostic criteria.\r\nPatients and methods: Thirty-four patients (20 males, 14 females; mean age: 16.0\u00b12.1 years; range, 10 to 18 years) diagnosed with PEDBD between January 2010 and December 2019 were retrospectively evaluated. Patients were reclassified according to 1990 International Study Group (ISG) criteria, 2014 International Criteria for Beh\u00e7et\u2019s Disease (ICBD), and PEDBD criteria.\r\nResults: The mean age at diagnosis was 12.6\u00b13.1 years, the median diagnosis delay time was 12.0 (range, 4.5 to 27.0) months, and the mean age at symptom onset was 10.8\u00b12.9 years. The mean follow-up period was 31.9\u00b120.9 months. Oral aphthous ulcer was observed in 33 (97.1%), genital ulcer in 16 (47.0%), ocular involvement in 15 (44.1%), skin lesion in 11 (32.3%), joint involvement in nine (26.4%), both vascular and neurological involvement in six (17.6%) patients. The pathergy test was positive in 11 (37.8%) patients, and human leukocyte antigen (HLA)-B51 was positive in 11 (78.5%) of 14 patients. The rates of patients meeting the criteria for ISG, ICBD, and PEDBD were 52.9%, 82.4%, and 50.0%, respectively.\r\nConclusion: Pathergy and HLA-B51 can be used as supportive findings in patients who do not meet the diagnostic criteria. However, expert opinion is still the gold standard in diagnosis.<\/jats:p>","DOI":"10.46497\/archrheumatol.2023.9651","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T10:08:05Z","timestamp":1707214085000},"page":"282-290","source":"Crossref","is-referenced-by-count":9,"title":["Pediatric Beh\u00e7et\u2019s disease: Experience of a single tertiary center"],"prefix":"10.5152","volume":"38","author":[{"family":"Ceyhun A\u00e7ar\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Rana \u0130\u015fg\u00fcder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"R\u00fcya Torun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Balahan Makay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"\u015eevket Erbil \u00dcnsal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Batu ED. Diagnostic\/classification criteria in pediatric Beh\u00e7et's disease. Rheumatol Int 2019;39:37-46.","DOI":"10.1007\/s00296-018-4208-9"},{"key":"ref-2","unstructured":"Shahram F, Nadji A, Akhlaghi M, Faezi ST, ChamsDavatchi C, Shams H, et al. Paediatric Beh\u00e7et's disease in Iran: Report of 204 cases. Clin Exp Rheumatol 2018;36(6 Suppl 115):135-40."},{"key":"ref-3","doi-asserted-by":"crossref","unstructured":"Ishido T, Horita N, Takeuchi M, Kawagoe T, Shibuya E, Yamane T, et al. Clinical manifestations of Beh\u00e7et's disease depending on sex and age: Results from Japanese nationwide registration. Rheumatology (Oxford) 2017;56:1918-27.","DOI":"10.1093\/rheumatology\/kex285"},{"key":"ref-4","doi-asserted-by":"crossref","unstructured":"Kurt T, Ayd\u0131n F, Sezer M, Tekg\u00f6z PN, Tekin ZE, \u00c7elikel E, et al. Performance of diagnostic criteria in pediatric Beh\u00e7et's disease. Rheumatol Int 2022;42:127-32.","DOI":"10.1007\/s00296-020-04777-0"},{"key":"ref-5","doi-asserted-by":"crossref","unstructured":"Davatchi F, Sadeghi Abdollahi B, Chams-Davatchi C, Shahram F, Shams H, Nadji A, et al. The saga of diagnostic\/classification criteria in Behcet's disease. Int J Rheum Dis 2015;18:594-605.","DOI":"10.1111\/1756-185X.12520"},{"key":"ref-6","doi-asserted-by":"crossref","unstructured":"Criteria for diagnosis of Beh\u00e7et's disease. International Study Group for Beh\u00e7et's Disease. Lancet 1990;335:1078-80.","DOI":"10.1016\/0140-6736(90)92643-V"},{"key":"ref-7","doi-asserted-by":"crossref","unstructured":"International Team for the Revision of the International Criteria for Beh\u00e7et's Disease (ITR-ICBD). The International Criteria for Beh\u00e7et's Disease (ICBD): A collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol 2014;28:338-47.","DOI":"10.1111\/jdv.12107"},{"key":"ref-8","doi-asserted-by":"crossref","unstructured":"Kon\u00e9-Paut I, Shahram F, Darce-Bello M, Cantarini L, Cimaz R, Gattorno M, et al. Consensus classification criteria for paediatric Beh\u00e7et's disease from a prospective observational cohort: PEDBD. Ann Rheum Dis 2016;75:958-64.","DOI":"10.1136\/annrheumdis-2015-208491"},{"key":"ref-9","doi-asserted-by":"crossref","unstructured":"Yildiz M, Haslak F, Adrovic A, Sahin S, Koker O, Barut K, et al. Pediatric Beh\u00e7et's Disease. Front Med (Lausanne) 2021;8:627192.","DOI":"10.3389\/fmed.2021.627192"},{"key":"ref-10","doi-asserted-by":"crossref","unstructured":"Gallizzi R, Pidone C, Cantarini L, Finetti M, Cattalini M, Filocamo G, et al. A national cohort study on pediatric Beh\u00e7et's disease: Cross-sectional data from an Italian registry. Pediatr Rheumatol Online J 2017;15:84.","DOI":"10.1186\/s12969-017-0213-x"},{"key":"ref-11","doi-asserted-by":"crossref","unstructured":"Karincaoglu Y, Borlu M, Toker SC, Akman A, Onder M, Gunasti S, et al. Demographic and clinical properties of juvenile-onset Beh\u00e7et's disease: A controlled multicenter study. J Am Acad Dermatol 2008;58:579-84.","DOI":"10.1016\/j.jaad.2007.10.452"},{"key":"ref-12","unstructured":"Gezgin Y\u0131ld\u0131r\u0131m D, Bakkalo\u011flu SA, Hasanreisoglu M, Buyan N. Disease activity and outcomes in juvenile Beh\u00e7et's disease: 10 years' experience of a single centre. Clin Exp Rheumatol 2020;38 Suppl 127:105-11."},{"key":"ref-13","doi-asserted-by":"crossref","unstructured":"Butbul Aviel Y, Batu ED, S\u00f6zeri B, Aktay Ayaz N, Baba L, Amarilyo G, et al. Characteristics of pediatric Beh\u00e7et's disease in Turkey and Israel: A crosssectional cohort comparison. Semin Arthritis Rheum 2020;50:515-20.","DOI":"10.1016\/j.semarthrit.2020.01.013"},{"key":"ref-14","doi-asserted-by":"crossref","unstructured":"Ekici Tekin Z, \u00c7elikel E, Aydin F, Kurt T, Sezer M, Tekg\u00f6z N, et al. Juvenile Beh\u00e7et's disease: A tertiary center experience. Clin Rheumatol 2022;41:187-94.","DOI":"10.1007\/s10067-021-05896-0"},{"key":"ref-15","unstructured":"\u00c7irkino\u011flu MS, Demir S, Bilginer Y, \u00d6zen S. Beh\u00e7et's disease in children: Single-center experience. Turk Pediatri Ars 2019;54:179-84."},{"key":"ref-16","doi-asserted-by":"crossref","unstructured":"Nanthapisal S, Klein NJ, Ambrose N, Eleftheriou D, Brogan PA. Paediatric Beh\u00e7et's disease: A UK tertiary centre experience. Clin Rheumatol 2016;35:2509-16.","DOI":"10.1007\/s10067-016-3187-z"},{"key":"ref-17","unstructured":"Makmur EL, Myers SH, Hanns L, Haskard DO, Brogan P, Ambrose N. Comparing the clinical profile of adults and children with Beh\u00e7et's syndrome in the UK. Clin Exp Rheumatol 2019;37 Suppl 121:48-51."},{"key":"ref-18","doi-asserted-by":"crossref","unstructured":"Hatemi G, Christensen R, Bang D, Bodaghi B, Celik AF, Fortune F, et al. 2018 update of the EULAR recommendations for the management of Beh\u00e7et's syndrome. Ann Rheum Dis 2018;77:808-18.","DOI":"10.1136\/annrheumdis-2018-213225"},{"key":"ref-19","doi-asserted-by":"crossref","unstructured":"Emmi G, Bettiol A, Silvestri E, Di Scala G, Becatti M, Fiorillo C, et al. Vascular Beh\u00e7et's syndrome: An update. Intern Emerg Med 2019;14:645-52.","DOI":"10.1007\/s11739-018-1991-y"},{"key":"ref-20","doi-asserted-by":"crossref","unstructured":"Uluduz D, Midi I, Duman T, Colakoglu S, T\u00fcfekci A, Bakar M, et al. Beh\u00e7et's disease as a causative factor of cerebral venous sinus thrombosis: Subgroup analysis of data from the VENOST study. Rheumatology (Oxford) 2019;58:600-8.","DOI":"10.1093\/rheumatology\/key153"},{"key":"ref-21","doi-asserted-by":"crossref","unstructured":"Wesner N, Fenaux P, Jachiet V, Ades L, Fain O, Mekinian A; MINHEMON (French Network of dysimmune disorders associated with hemopathies). Beh\u00e7et's-like syndrome and other dysimmunitary manifestations related to myelodysplastic syndromes with trisomy 8. Rev Med Interne 2021;42:170-6.","DOI":"10.1016\/j.revmed.2020.08.016"},{"key":"ref-22","doi-asserted-by":"crossref","unstructured":"Oka S, Ono K, Nohgawa M. The acquisition of trisomy 8 associated with Beh\u00e7et's-like disease in myelodysplastic syndrome. Leuk Res Rep 2020;13:100196.","DOI":"10.1016\/j.lrr.2020.100196"},{"key":"ref-23","doi-asserted-by":"crossref","unstructured":"Soysal T, Saliho\u011flu A, Esato\u011flu SN, G\u00fclt\u00fcrk E, E\u015fkazan AE, Hatemi G, et al. Bone marrow transplantation for Beh\u00e7et's disease: A case report and systematic review of the literature. 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