{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:08:53Z","timestamp":1777860533502,"version":"3.51.4"},"reference-count":26,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"4","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Rheumatology"],"abstract":"<jats:p>Objectives: The study aimed to evaluate the frequency of diastolic dysfunction (DD) in patients with Beh\u00e7et's disease (BD) and its relationship with clinical manifestations.\r\nPatients and methods: Seventy patients (35 females, 35 males; mean age: 39.3\u00b111.0 years; range, 21 to 61 years) with BD and 50 healthy controls (27 females, 23 males; mean age: 38.8\u00b110.0 years; range, 23 to 62 years) were included in the case-control study between October 2023 and December 2023. Age, sex, smoking status, disease duration, mucocutaneous involvement, other organ involvement, treatment received of the patients were recorded. The E\/A ratio (the ratio of early diastolic wave to the atrial wave) and the E\/E' ratio (the ratio of early transmitral filling velocity to early diastolic mitral annular velocity), which are markers of DD, were measured by transthoracic echocardiography.\r\nResults: Diastolic dysfunction was observed in 27.1% (n=19) of BD patients and 8% (n=4) of healthy controls (p=0.017). Male dominance was observed in patients with major organ involvement (MOI) compared to patients with isolated mucocutaneous involvement (p=0.001). While MOI was observed at a rate of 65.7%, ocular involvement, among the MOIs, constituted 52.9% of all BD patients. The percentage of patients with a mitral E\/A ratio<\/jats:p>","DOI":"10.46497\/archrheumatol.2024.10772","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:56:27Z","timestamp":1740988587000},"page":"624-630","source":"Crossref","is-referenced-by-count":1,"title":["Diastolic dysfunction in Beh\u00e7et's disease and its relationship with clinical manifestations of the disease: A case-control study"],"prefix":"10.5152","volume":"39","author":[{"family":"Gizem Varkal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Rabia Eker Ak\u0131ll\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"\u0130pek T\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Zeynep T\u00fcz\u00fcn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Burak Mete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"S\u00fcleyman \u00d6zbek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Tong B, Liu X, Xiao J, Su G. 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