{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T05:19:18Z","timestamp":1772255958568,"version":"3.50.1"},"reference-count":0,"publisher":"Sociedade Portuguesa de Neurologia","issue":"1","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sinapse"],"abstract":"<jats:p>Introduction: Studies have shown the worsening of migraine associated with the COVID-19 infection and the pandemic more broadly. COVID-19 vaccination has also been associated with symptomatic headache, with high frequency among migraineurs. We aimed to assess the impact of COVID-19 diagnosis and vaccine administration on migraine, during the SARS-CoV-2 pandemic.\n\nMethods: An online questionnaire was sent to migraine patients followed in a neurology outpatient clinic between March and November 2022. The survey inquired about migraine symptoms and treatment changes, as well as sleep changes, anxiety, and depressive symptoms during the pandemic, after a COVID-19 diagnosis and\/or vaccination.\n\nResults: Out of the 185 patients included, 108 (58.4%) reported a change in headache pattern (intensity, frequency, and\/or pain quality) and 47% reported higher intensity and frequency. The pattern changes occurred before the COVID-19 diagnosis in 41%. Of all the participants with headache changes 72.2% needed to intensify medication (abortive or prophylaxis), regardless of infection status. High levels of insomnia, anxiety, and depressive symptoms were found among patients with worsening migraine, irrespective of COVID-19 diagnosis. After vaccination, 49 (27.1%) described a change in headache pattern, with a worsening pattern in 29 (16%). In half, this change occurred for up to 3 weeks.\n\nConclusion: Worsening of migraine was more likely associated with other factors related to the pandemic rather than COVID-19 diagnosis. COVID-19 vaccination might have acted as an additional but less relevant and temporary trigger for migraine worsening.<\/jats:p>","DOI":"10.46531\/sinapse\/ao\/230065\/2024","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T17:16:59Z","timestamp":1712078219000},"page":"12-22","source":"Crossref","is-referenced-by-count":0,"title":["Impact of SARS-CoV-2 Infection and Vaccination on Migraine Symptoms during the COVID-19 Pandemic"],"prefix":"10.46531","volume":"24","author":[{"given":"L\u00e9nia","family":"Silva","sequence":"first","affiliation":[]},{"given":"Adriana","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Pontes","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Arlinda","family":"Chiteculo","sequence":"additional","affiliation":[]},{"given":"Beatriz","family":"Soares","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"Teixeira","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Cardia","sequence":"additional","affiliation":[]},{"given":"Mariana","family":"Monteiro","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Eiras","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Costa","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"Laranjinha","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Andrade","sequence":"additional","affiliation":[]},{"given":"Denis","family":"Gabriel","sequence":"additional","affiliation":[]}],"member":"25677","published-online":{"date-parts":[[2024,4,2]]},"container-title":["Sinapse"],"original-title":[],"link":[{"URL":"https:\/\/sinapse.pt\/index.php\/journal\/article\/download\/42\/38","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sinapse.pt\/index.php\/journal\/article\/download\/42\/38","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T04:12:09Z","timestamp":1714623129000},"score":1,"resource":{"primary":{"URL":"https:\/\/sinapse.pt\/index.php\/journal\/article\/view\/42"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,5,2]]}},"URL":"https:\/\/doi.org\/10.46531\/sinapse\/ao\/230065\/2024","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2628516\/v1","asserted-by":"object"}]},"ISSN":["2184-4240","1645-281X"],"issn-type":[{"value":"2184-4240","type":"electronic"},{"value":"1645-281X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,2]]}}}