{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:37:09Z","timestamp":1787031429046,"version":"build-2736575974"},"reference-count":0,"publisher":"MJH Life Sciences","issue":"3909","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,8]]},"abstract":"<jats:p>PURPOSE:\nTo present a rare case of proximal-type epithelioid sarcoma (PES) of the vulva and highlight the importance of a multidisciplinary approach in its diagnosis and treatment, especially in the context of SMARCB1 loss.\n\nMETHODS:\nA 41-year-old woman presented with a painless mass in the right labia majora. An MRI, PET\/CT, histopathology, and immunohistochemistry confirmed the diagnosis of PES with loss of SMARCB1 expression. The patient underwent wide local excision followed by re-excision and inguinal lymphadenectomy. Adjuvant radiotherapy was initiated but discontinued at 46 Gy due to grade 2 skin reactions and wound dehiscence.\n\nRESULTS:\nPosttreatment PET\/CT imaging posed challenges in distinguishing between recurrence and radiation-induced changes. Despite these challenges, the patient remained disease free during the 2-year follow-up period. This case underscores the diagnostic and therapeutic complexities involved in treating PES, particularly in sensitive anatomical regions such as the vulva. The loss of SMARCB1 served as a key molecular marker guiding diagnosis and therapeutic decisions.\n\nCONCLUSION:\nThe case underscores the importance of a comprehensive, individualized treatment approach, including surgery, radiotherapy, and advanced imaging, for managing rare malignancies such as vulvar PES.<\/jats:p>","DOI":"10.46883\/2025.25921054","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T15:33:29Z","timestamp":1761924809000},"page":"394-399","source":"Crossref","is-referenced-by-count":1,"title":["Unraveling the Complexities of Proximal-Type Epithelioid Sarcoma of the Vulva"],"prefix":"10.46883","member":"25947","published-online":{"date-parts":[[2025,10,27]]},"container-title":["ONCOLOGY"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T15:33:29Z","timestamp":1761924809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cancernetwork.com\/view\/unraveling-the-complexities-of-proximal-type-epithelioid-sarcoma-of-the-vulva"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":0,"issue-title":["October 2025"],"journal-issue":{"issue":"3909","published-online":{"date-parts":[[2025,10,24]]},"published-print":{"date-parts":[[2025,10,8]]}},"URL":"https:\/\/doi.org\/10.46883\/2025.25921054","relation":{},"ISSN":["0890-9091"],"issn-type":[{"value":"0890-9091","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,8]]}}}