{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:40:34Z","timestamp":1785436834489,"version":"3.56.0"},"reference-count":6,"publisher":"MJH Life Sciences","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,4]]},"abstract":"<jats:p>Adult T-cell leukemia\/lymphoma (ATLL) is an aggressive lymphoma with a poor prognosis. The human T-lymphotropic virus 1 (HTLV-1) is associated with immunodeficiency and increased extranodal involvement in patients with diffuse large B-cell lymphoma (DLBCL). We report on a 47-year-old woman with spastic paraparesis and hepatitis B who was diagnosed with the acute form of ATLL. The clinical picture reveals peripheral generalized lymphadenopathy and splenomegaly. Findings on a hematologic exam indicated leukocytosis with lymphocytosis. A bone marrow biopsy\/aspiration confirmed 50% T-cell lymphoid infiltration. Biochemistry results revealed hypercalcemia and a high lactate dehydrogenase value. Results of a  CT scan indicated abdominal and thoracic adenopathy as well as moderate splenomegaly. A supraclavicular lymph node biopsy established a DLBCL diagnosis. The final diagnosis was composite lymphoma, DLBCL, and ATLL. The CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate [Oncovin], and prednisone) regimen was chosen due to the patient\u2019s ECOG performance status. Multiple infectious complications were diagnosed during chemotherapy-induced secondary aplasia. A complete remission, confirmed via PET-CT imaging, was obtained. After 1 month, a skin tumor on the upper right thigh was discovered and biopsied, and the histopathological exam and immunochemistry findings indicated Epstein-Barr virus\u2013DLBCL lymphoma. The association of 2 aggressive lymphomas in a single HTLV-1 carrier is a rare report, and the evolution was severe, complicated by opportunistic infections, and unfavorable.<\/jats:p>","DOI":"10.46883\/2026.25921072","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:43:44Z","timestamp":1777988624000},"page":"162","source":"Crossref","is-referenced-by-count":1,"title":["Adult T-Cell Leukemia\/Lymphoma and Epstein-Barr Virus-Positive DLBCL: A Rare Concomitant Association"],"prefix":"10.46883","volume":"40","author":[{"given":"Viola","family":"Popov","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04fkbqt11","id-type":"ROR","asserted-by":"publisher"}],"name":"Spitalul Clinic Colentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Grasu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04fkbqt11","id-type":"ROR","asserted-by":"publisher"}],"name":"Spitalul Clinic Colentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horia","family":"Bumbea","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051v1dy68","id-type":"ROR","asserted-by":"publisher"}],"name":"Bucharest Emergency University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camelia","family":"Dobrea","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04fm87419","id-type":"ROR","asserted-by":"publisher"}],"name":"Carol Davila University of Medicine and Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Mastalier","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04fkbqt11","id-type":"ROR","asserted-by":"publisher"}],"name":"Spitalul Clinic Colentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ion","family":"Dumitru","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051v1dy68","id-type":"ROR","asserted-by":"publisher"}],"name":"Bucharest Emergency University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela","family":"Voicu","sequence":"additional","affiliation":[{"name":"Colentina Clinical Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Andreescu","sequence":"additional","affiliation":[{"name":"Colentina Clinical Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25947","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1. Ratner L. Adult T cell leukemia lymphoma. Front Biosci. 2004;9:2852-2859. doi:10.2741\/1442","DOI":"10.2741\/1442"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"2. Shibusawa M, Kidoguchi K, Tanimoto T. Epstein-Barr virus-positive diffuse large B cell lymphoma. In: Gallamini A, Juweid M, eds. Lymphoma [Internet]. Exon Publications; 2021.","DOI":"10.36255\/exon-publications.lymphoma.2021.ebv-dlbcl"},{"key":"ref2","unstructured":"3. Sakamoto H, Imaizumi Y, Niino D, et al. Composite adult T-cell leukemia\/lymphoma and Epstein-Barr virus-positive diffuse large B-cell lymphoma. Article in Japanese. Rinsho Ketsueki. 2020;61(4):305-311. doi:10.11406\/rinketsu.61.305"},{"key":"ref3","unstructured":"4. Ba Y, Shi Y, Jiang W, Feng J, et al. Current management of chemotherapy-induced neutropenia in adults: key points and new challenges: Committee of Neoplastic Supportive-Care (CONS), China Anti-Cancer Association Committee of Clinical Chemotherapy, China Anti-Cancer Association. Cancer Biol Med. 2020 Nov 15;17(4):896-909. doi: 10.20892\/j.issn.2095-3941.2020.0069. Epub 2020 Dec 15. PMID: 33299642; PMCID: PMC7721096."},{"key":"ref4","unstructured":"5. R-CHOP-21. Thames Valley Cancer Alliance, Oxford University Hospitals NHS Foundation Trust. Accessed March 12, 2026. https:\/\/tinyurl.com\/3ktcdp2b"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"6. Tobinai K, Ohtsu T, Hayashi M, et al. Epstein-Barr virus (EBV) genome carrying monoclonal B-cell lymphoma in a patient with adult T-cell leukemia-lymphoma. Leuk Res. 1991;15(9):837-846. doi:10.1016\/0145-2126(91)90468-9","DOI":"10.1016\/0145-2126(91)90468-9"}],"container-title":["ONCOLOGY"],"original-title":[],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:43:58Z","timestamp":1777988638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cancernetwork.com\/view\/adult-t-cell-leukemia-lymphoma-and-epstein-barr-virus-positive-dlbcl-a-rare-concomitant-association"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,4]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,4,21]]},"published-print":{"date-parts":[[2026,4,4]]}},"URL":"https:\/\/doi.org\/10.46883\/2026.25921072","relation":{},"ISSN":["0890-9091","2767-7389"],"issn-type":[{"value":"0890-9091","type":"print"},{"value":"2767-7389","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,4]]}}}