{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:43:24Z","timestamp":1792118604889,"version":"4.4.0"},"reference-count":24,"publisher":"SAABRON PRESS","issue":"3","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the best cure for many hematologic diseases, but it is associated with multiple short and long term cardiovascular adverse effects. This retrospective study assesses the short-term cardiovascular consequences after allo-HSCT and compares the risk of developing cardiotoxicity based on conditioning regimens and post-transplant prophylactic medications. A total of 310 patients were identified at the American University of Beirut Medical Center (AUBMC), of whom 255 were followed up for 100 days post-transplant. There was a significant decrease in left ventricular ejection fraction (LVEF), from a mean of 59.14% pre-transplant to 58.44% post-transplant (P= 0.037). Significant decreases were also noted in the E wave, E\u2019 wave, and E\/A ratio (P &lt;0.01, &lt;0.001, and 0.006, respectively), while no significant changes were observed in A wave or E\/E\u2019 ratio (P= 0.197 and 0.078, respectively). No significant decrease in global longitudinal strain was noted (P=0.18). Haploidentical transplants, cyclophosphamide, and sequential conditioning regimens were associated with reduced LVEF (P= 0.002, 0.007 and 0.019, respectively). Among those followed up for 100 days, 8 patients (3.2%) developed moderate or large pericardial effusion. While the average decrease in LVEF was of no clinical significance, the percentage of patients with reduced LVEF (&lt;50%) increased from 3.1% pre-transplant to 6.7% at 100 days. These subclinical changes in LVEF and diastolic measurements are not fully understood. We recommend serial echocardiographic follow-ups to assess their potential clinical relevance and the risk of cardiotoxicity later in life, particularly those undergoing haploidentical transplant, receiving cyclophosphamide or sequential conditioning regimens.<\/jats:p>","DOI":"10.46989\/001c.140766","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T11:15:09Z","timestamp":1751454909000},"source":"Crossref","is-referenced-by-count":5,"title":["The short-term Cardiotoxicity after Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective single center experience"],"prefix":"10.46989","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-9428","authenticated-orcid":false,"given":"Jean","family":"El Cheikh","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut, Medical Center, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6514-1283","authenticated-orcid":false,"given":"Ibrahim","family":"Hasan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00wmm6v75","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine, American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Saleh","sequence":"additional","affiliation":[{"name":"Research Program, Department of Internal Medicine, American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zyad","family":"Saifi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, American University of Beirut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Ammar","family":"Al Kouchak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, American University of Beirut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Moukalled","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00wmm6v75","id-type":"ROR","asserted-by":"publisher"}],"name":"Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Abu Dalle","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00wmm6v75","id-type":"ROR","asserted-by":"publisher"}],"name":"Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Fakhreddine","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00wmm6v75","id-type":"ROR","asserted-by":"publisher"}],"name":"Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Skouri","sequence":"additional","affiliation":[{"name":"Cardiology Program, Department of Internal Medicine, American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26435","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1365-2141.2008.07165.x","article-title":"Cardiac and cardiovascular consequences after haematopoietic stem cell transplantation","volume":"142","author":"A. 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