{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:48:15Z","timestamp":1785415695201,"version":"3.56.0"},"reference-count":57,"publisher":"SAABRON PRESS","issue":"1","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Approximately 90% of patients with multiple myeloma experience significant pain from osseous involvement during their lifetime. Untreated osseous involvement results in vertebral compression fractures, leading to negative consequences for quality of life. Vertebral augmentation procedures, including percutaneous vertebroplasty and kyphoplasty, offer better and faster pain control and likely lower morbidity compared with non-operative interventions. Our review provides an up-to-date summary of the indications, contraindications, timing, outcomes, and potential complications of vertebral augmentation procedures to guide practicing oncologists in effectively managing bone disease in patients with multiple myeloma.<\/jats:p>","DOI":"10.46989\/001c.92984","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T08:22:31Z","timestamp":1708417351000},"source":"Crossref","is-referenced-by-count":7,"title":["The Role of Vertebral Augmentation Procedures in the Management of Multiple Myeloma"],"prefix":"10.46989","volume":"6","author":[{"given":"Nishanth","family":"Thalambedu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00xcryt71","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Arkansas for Medical Sciences","department":["Hematology and Oncology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudassar","family":"Kamran","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00xcryt71","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Arkansas for Medical Sciences","department":["Interventional Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Al-Hadidi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00xcryt71","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Arkansas for Medical Sciences","department":["Myeloma Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26435","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"issue":"7","key":"ref1","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00198-003-1412-5","article-title":"Incident vertebral fractures and mortality in older women: a prospective study","volume":"14","author":"D. M. Kado","year":"2003","journal-title":"Osteoporosis International","ISSN":"https:\/\/id.crossref.org\/issn\/0937-941X","issn-type":"print"},{"issue":"3","key":"ref2","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s001980050063","article-title":"Reduced pulmonary function in patients with spinal osteoporotic fractures","volume":"8","author":"C. Schlaich","year":"1998","journal-title":"Osteoporosis International","ISSN":"https:\/\/id.crossref.org\/issn\/0937-941X","issn-type":"print"},{"issue":"1","key":"ref3","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/ajh.24236","article-title":"Myeloma today: Disease definitions and treatment advances","volume":"91","author":"S. Vincent Rajkumar","year":"2016","journal-title":"American Journal of Hematology","ISSN":"https:\/\/id.crossref.org\/issn\/0361-8609","issn-type":"print"},{"issue":"20","key":"ref4","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1182\/blood-2014-07-552059","article-title":"Curing myeloma at last: defining criteria and providing the evidence","volume":"124","author":"Bart Barlogie","year":"2014","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"12","key":"ref5","first-page":"A4945","article-title":"Pain reduction after percutaneous vertebroplasty for myeloma-associated vertebral fractures","volume":"61","author":"A. Simony","year":"2014","journal-title":"Dan Med J"},{"issue":"3","key":"ref6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/s1470-2045(11)70008-0","article-title":"Balloon kyphoplasty versus non-surgical fracture management for treatment of painful vertebral body compression fractures in patients with cancer: a multicentre, randomised controlled trial","volume":"12","author":"James Berenson","year":"2011","journal-title":"The Lancet Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/1470-2045","issn-type":"print"},{"issue":"9","key":"ref7","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1200\/jco.2002.09.097","article-title":"Kyphoplasty in the Treatment of Osteolytic Vertebral Compression Fractures as a Result of Multiple Myeloma","volume":"20","author":"S. Dudeney","year":"2002","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"issue":"2","key":"ref8","first-page":"166","article-title":"[Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty]","volume":"33","author":"P. Galibert","year":"1987","journal-title":"Neurochirurgie"},{"issue":"2","key":"ref9","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/00007632-200101150-00008","article-title":"An ex vivo biomechanical evaluation of an inflatable bone tamp used in the treatment of compression fracture","volume":"26","author":"Stephen M. Belkoff","year":"2001","journal-title":"Spine","ISSN":"https:\/\/id.crossref.org\/issn\/0362-2436","issn-type":"print"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1121981","DOI":"10.3389\/fsurg.2023.1121981","article-title":"Re-expansion of vertebral compression fractures in patients with multiple myeloma with percutaneous vertebroplasty using spinejack implants: a preliminary and retrospective study","volume":"10","author":"Claudio Pusceddu","year":"2023","journal-title":"Frontiers in Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/2296-875X","issn-type":"print"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/104546","article-title":"Diagnosis and Treatment of Bone Disease in Multiple Myeloma: Spotlight on Spinal Involvement","volume":"2013","author":"Patrizia Tosi","year":"2013","journal-title":"Scientifica","ISSN":"https:\/\/id.crossref.org\/issn\/2090-908X","issn-type":"print"},{"issue":"1","key":"ref12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jvir.2021.10.002","article-title":"Expandable Intravertebral Implant in Cancer-Related Vertebral Compression Fractures: A Retrospective Review of 36 Implantations","volume":"33","author":"Fran\u00e7ois H. Cornelis","year":"2022","journal-title":"Journal of Vascular and Interventional Radiology","ISSN":"https:\/\/id.crossref.org\/issn\/1051-0443","issn-type":"print"},{"issue":"3","key":"ref13","doi-asserted-by":"publisher","first-page":"294","DOI":"10.5144\/0256-4947.2011.294","article-title":"Percutaneous vertebroplasty complications","volume":"31","author":"Nizar A. Al-Nakshabandi","year":"2011","journal-title":"Annals of Saudi Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0256-4947","issn-type":"print"},{"issue":"5","key":"ref14","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1093\/ons\/opy186","article-title":"Utility of Cement Augmentation via Percutaneous Fenestrated Pedicle Screws for Stabilization of Cancer-Related Spinal Instability","volume":"16","author":"Ori Barzilai","year":"2019","journal-title":"Operative Neurosurgery","ISSN":"https:\/\/id.crossref.org\/issn\/2332-4252","issn-type":"print"},{"issue":"5","key":"ref15","doi-asserted-by":"publisher","first-page":"E12","DOI":"10.3171\/2021.2.focus201121","article-title":"Safety and efficacy of cement augmentation with fenestrated pedicle screws for tumor-related spinal instability","volume":"50","author":"Elie Massaad","year":"2021","journal-title":"Neurosurg Focus","ISSN":"https:\/\/id.crossref.org\/issn\/1092-0684","issn-type":"print"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"106675","DOI":"10.1016\/j.clineuro.2021.106675","article-title":"Fenestrated pedicle screws for thoracolumbar instrumentation in patients with poor bone quality: Case series and systematic review of the literature","volume":"206","author":"Jeff Ehresman","year":"2021","journal-title":"Clinical Neurology and Neurosurgery","ISSN":"https:\/\/id.crossref.org\/issn\/0303-8467","issn-type":"print"},{"issue":"1","key":"ref17","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00198-010-1265-7","article-title":"Age-related hyperkyphosis, independent of spinal osteoporosis, is associated with impaired mobility in older community-dwelling women","volume":"22","author":"W. B. Katzman","year":"2011","journal-title":"Osteoporosis International","ISSN":"https:\/\/id.crossref.org\/issn\/0937-941X","issn-type":"print"},{"issue":"10","key":"ref18","doi-asserted-by":"publisher","first-page":"218","DOI":"10.21037\/atm.2019.01.65","article-title":"Intra- and interobserver reliability of the Spinal Instability Neoplastic Score system for instability in spine metastases: a systematic review and meta-analysis","volume":"7","author":"Zach Pennington","year":"2019","journal-title":"Annals of Translational Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/2305-5839","issn-type":"print"},{"issue":"7","key":"ref19","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.spinee.2015.12.083","article-title":"Is early vertebroplasty\/kyphoplasty justified in multiple myeloma given the rapid vertebral fracture progression?","volume":"16","author":"Ioannis D. Papanastassiou","year":"2016","journal-title":"The Spine Journal","ISSN":"https:\/\/id.crossref.org\/issn\/1529-9430","issn-type":"print"},{"issue":"1","key":"ref20","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1186\/s12885-016-2495-7","article-title":"Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing","volume":"16","author":"Karan Malhotra","year":"2016","journal-title":"BMC Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2407","issn-type":"print"},{"issue":"10","key":"ref21","first-page":"1654","article-title":"Functional results of vertebral augmentation techniques in pathological vertebral fractures of myelomatous patients","volume":"98","author":"K.C. K\u00f6se","year":"2006","journal-title":"J Natl Med Assoc"},{"issue":"3","key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-019-0187-7","article-title":"The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)","volume":"9","author":"Charalampia Kyriakou","year":"2019","journal-title":"Blood Cancer Journal","ISSN":"https:\/\/id.crossref.org\/issn\/2044-5385","issn-type":"print"},{"issue":"12","key":"ref23","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1038\/leu.2013.162","article-title":"Vertebral augmentation in the treatment of pathologic compression fractures in 792 patients with multiple myeloma","volume":"27","author":"E Erdem","year":"2013","journal-title":"Leukemia","ISSN":"https:\/\/id.crossref.org\/issn\/0887-6924","issn-type":"print"},{"issue":"1","key":"ref24","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3174\/ajnr.a3622","article-title":"Vertebral augmentation in patients with multiple myeloma: a pooled analysis of published case series","volume":"35","author":"O.A. Khan","year":"2014","journal-title":"American Journal of Neuroradiology","ISSN":"https:\/\/id.crossref.org\/issn\/0195-6108","issn-type":"print"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/01.blo.0000131642.96984.74","article-title":"Kyphoplasty enhances function and structural alignment in multiple myeloma","volume":"426","author":"Joseph M Lane","year":"2004","journal-title":"Clinical Orthopaedics and Related Research","ISSN":"https:\/\/id.crossref.org\/issn\/0009-921X","issn-type":"print"},{"issue":"3","key":"ref26","doi-asserted-by":"publisher","first-page":"162","DOI":"10.4184\/asj.2011.5.3.162","article-title":"Efficacy of unipedicular baloon kyphoplasty for treatment of multiple myeloma vertebral lesions","volume":"5","author":"Giovanni Andrea La Maida","year":"2011","journal-title":"Asian Spine Journal","ISSN":"https:\/\/id.crossref.org\/issn\/1976-1902","issn-type":"print"},{"issue":"2","key":"ref27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jocn.2009.04.007","article-title":"Clinical and radiographic results of balloon kyphoplasty for treatment of vertebral body metastases and multiple myelomas","volume":"17","author":"Sedat Dalbayrak","year":"2010","journal-title":"Journal of Clinical Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0967-5868","issn-type":"print"},{"issue":"1","key":"ref28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.crad.2010.09.011","article-title":"Safety and efficacy of percutaneous vertebroplasty in malignancy: a systematic review","volume":"66","author":"C. Chew","year":"2011","journal-title":"Clinical Radiology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9260","issn-type":"print"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"582769","DOI":"10.1155\/2015\/582769","article-title":"Pulmonary Artery Cement Embolism after a Vertebroplasty","volume":"2015","author":"Anas Nooh","year":"2015","journal-title":"Case Reports in Orthopedics","ISSN":"https:\/\/id.crossref.org\/issn\/2090-6749","issn-type":"print"},{"issue":"8","key":"ref30","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00701-008-1503-3","article-title":"Intradural cement leakage: a rare complication of percutaneous vertebroplasty","volume":"150","author":"H. Sabuncuo\u011flu","year":"2008","journal-title":"Acta Neurochirurgica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6268","issn-type":"print"},{"issue":"3","key":"ref31","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/hon.3102","article-title":"The role of Vertebral Augmentation Procedures in the management of vertebral compression fractures secondary to multiple myeloma","volume":"41","author":"Kelechi C. Eseonu","year":"2022","journal-title":"Hematological Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0278-0232","issn-type":"print"},{"issue":"4","key":"ref32","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00586-002-0512-9","article-title":"Load shift of the intervertebral disc after a vertebroplasty: a finite-element study","volume":"12","author":"G. Baroud","year":"2003","journal-title":"European Spine Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0940-6719","issn-type":"print"},{"issue":"5","key":"ref33","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3322\/caac.20073","article-title":"Cancer statistics, 2010","volume":"60","author":"A. Jemal","year":"2010","journal-title":"CA: A Cancer Journal for Clinicians","ISSN":"https:\/\/id.crossref.org\/issn\/0007-9235","issn-type":"print"},{"issue":"5","key":"ref34","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.spinee.2006.10.020","article-title":"Percutaneous vertebral augmentation: an elevation in adjacent-level fracture risk in kyphoplasty as compared with vertebroplasty","volume":"7","author":"Bruce M. Frankel","year":"2007","journal-title":"The Spine Journal","ISSN":"https:\/\/id.crossref.org\/issn\/1529-9430","issn-type":"print"},{"issue":"3","key":"ref35","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/s0033-8389(05)70042-7","article-title":"Percutaneous vertebroplasty with polymethylmethacrylate. Technique, indications, and results","volume":"36","author":"Herv\u00e9 Deramond","year":"1998","journal-title":"Radiologic Clinics of North America","ISSN":"https:\/\/id.crossref.org\/issn\/0033-8389","issn-type":"print"},{"issue":"1 Suppl","key":"ref36","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3171\/spi.2003.98.1.0021","article-title":"Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients","volume":"98","author":"Daryl R. Fourney","year":"2003","journal-title":"Journal of Neurosurgery: Spine","ISSN":"https:\/\/id.crossref.org\/issn\/1547-5654","issn-type":"print"},{"issue":"1","key":"ref37","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1148\/radiol.2231010234","article-title":"Percutaneous vertebroplasty for severe osteoporotic vertebral body compression fractures","volume":"223","author":"Wilfred C. G. Peh","year":"2002","journal-title":"Radiology","ISSN":"https:\/\/id.crossref.org\/issn\/0033-8419","issn-type":"print"},{"issue":"5 Suppl","key":"ref38","first-page":"S96","article-title":"Vertebroplasty for osteoporotic compression fractures: current practice and evolving techniques","volume":"51","author":"K R Peters","year":"2002","journal-title":"Neurosurgery"},{"issue":"1","key":"ref39","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1148\/radiology.199.1.8633152","article-title":"Spinal metastases: indications for and results of percutaneous injection of acrylic surgical cement.","volume":"199","author":"A Weill","year":"1996","journal-title":"Radiology","ISSN":"https:\/\/id.crossref.org\/issn\/0033-8419","issn-type":"print"},{"issue":"1","key":"ref40","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/1529-0131(199801)41:1","article-title":"Percutaneous vertebroplasty treatment of steroid-induced osteoporotic compression fractures","volume":"41","author":"John M. Mathis","year":"1998","journal-title":"Arthritis &amp; Rheumatism","ISSN":"https:\/\/id.crossref.org\/issn\/0004-3591","issn-type":"print"},{"issue":"5","key":"ref41","doi-asserted-by":"publisher","first-page":"571","DOI":"10.14444\/5070","article-title":"Evaluating Treatment Strategies for Spinal Lesions in Multiple Myeloma: A Review of the Literature","volume":"12","author":"MANAN SUNIL Patel","year":"2018","journal-title":"International Journal of Spine Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/2211-4599","issn-type":"print"},{"issue":"1","key":"ref42","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.prro.2016.08.001","article-title":"Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence-Based Guideline","volume":"7","author":"Stephen Lutz","year":"2017","journal-title":"Practical Radiation Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/1879-8500","issn-type":"print"},{"issue":"4","key":"ref43","doi-asserted-by":"publisher","first-page":"101214","DOI":"10.1016\/j.adro.2023.101214","article-title":"Biological Effective Radiation Dose for Multiple Myeloma Palliation","volume":"8","author":"Ruby F. Meredith","year":"2023","journal-title":"Advances in Radiation Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/2452-1094","issn-type":"print"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.metabol.2017.11.012","article-title":"Biology and treatment of myeloma related bone disease","volume":"80","author":"Evangelos Terpos","year":"2018","journal-title":"Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"issue":"3","key":"ref45","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3171\/2016.8.spine16412","article-title":"Spine stereotactic radiosurgery for the treatment of multiple myeloma","volume":"26","author":"Jacob A. Miller","year":"2017","journal-title":"Journal of Neurosurgery: Spine","ISSN":"https:\/\/id.crossref.org\/issn\/1547-5654","issn-type":"print"},{"issue":"7","key":"ref46","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/jso.22101","article-title":"Kyphoplasty in patients with multiple myeloma a retrospective comparative pilot study","volume":"105","author":"Christian Kasperk","year":"2012","journal-title":"Journal of Surgical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-4790","issn-type":"print"},{"issue":"1","key":"ref47","first-page":"35","article-title":"Single fraction spine radiosurgery for myeloma epidural spinal cord compression","volume":"8","author":"R. Jin","year":"2009","journal-title":"J Exp Ther Oncol"},{"issue":"4","key":"ref48","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1046\/j.1365-2141.1997.d01-2108.x","article-title":"Long-term effects of localized spinal radiation therapy on vertebral fractures and focal lesions appearance in patients with multiple myeloma","volume":"96","author":"FREDERIC Lecouvet","year":"1997","journal-title":"British Journal of Haematology","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1048","issn-type":"print"},{"issue":"1","key":"ref49","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/s13014-020-01715-z","article-title":"Long-term outcome after combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) for vertebral tumors","volume":"15","author":"Frederic Bludau","year":"2020","journal-title":"Radiation Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/1748-717X","issn-type":"print"},{"issue":"3","key":"ref50","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/sj.bjp.0701148","article-title":"Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor <i>\u03b1<\/i>","volume":"121","author":"C. J. Woolf","year":"1997","journal-title":"British Journal of Pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1188","issn-type":"print"},{"issue":"1","key":"ref51","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00270-013-0624-0","article-title":"Percutaneous vertebroplasty for pain management in patients with multiple myeloma: is radiofrequency ablation necessary?","volume":"37","author":"Gianluigi Orgera","year":"2014","journal-title":"CardioVascular and Interventional Radiology","ISSN":"https:\/\/id.crossref.org\/issn\/0174-1551","issn-type":"print"},{"issue":"9","key":"ref52","doi-asserted-by":"publisher","first-page":"e045854","DOI":"10.1136\/bmjopen-2020-045854","article-title":"Vertebroplasty in patients with multiple myeloma with vertebral compression fractures: protocol for a single-blind randomised controlled trial","volume":"11","author":"Line Adsboell Wickstroem","year":"2021","journal-title":"BMJ Open","ISSN":"https:\/\/id.crossref.org\/issn\/2044-6055","issn-type":"print"},{"issue":"1","key":"ref53","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41408-017-0037-4","article-title":"Pathogenesis of bone disease in multiple myeloma: from bench to bedside","volume":"8","author":"Evangelos Terpos","year":"2018","journal-title":"Blood Cancer Journal","ISSN":"https:\/\/id.crossref.org\/issn\/2044-5385","issn-type":"print"},{"issue":"6","key":"ref54","doi-asserted-by":"publisher","first-page":"e12761","DOI":"10.1111\/ecc.12761","article-title":"Mechanisms of bone destruction in multiple myeloma","volume":"26","author":"E. Terpos","year":"2017","journal-title":"European Journal of Cancer Care","ISSN":"https:\/\/id.crossref.org\/issn\/0961-5423","issn-type":"print"},{"issue":"4","key":"ref55","first-page":"285","article-title":"Myeloma bone disease: pathogenesis and treatment","volume":"15","author":"E.K. O\u2019Donnell","year":"2017","journal-title":"Clin Adv Hematol Oncol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"100999","DOI":"10.1016\/j.blre.2022.100999","article-title":"The use of bone-modifying agents in multiple myeloma","volume":"57","author":"Munawwar Hussain","year":"2023","journal-title":"Blood Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0268-960X","issn-type":"print"},{"issue":"1","key":"ref57","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00270-011-0111-4","article-title":"Percutaneous vertebroplasty in multiple myeloma: prospective long-term follow-up in 106 consecutive patients","volume":"35","author":"Giovanni Carlo Anselmetti","year":"2012","journal-title":"CardioVascular and Interventional Radiology","ISSN":"https:\/\/id.crossref.org\/issn\/0174-1551","issn-type":"print"}],"container-title":["Clinical Hematology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chi.scholasticahq.com\/article\/92984-the-role-of-vertebral-augmentation-procedures-in-the-management-of-multiple-myeloma","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T12:47:38Z","timestamp":1750078058000},"score":1,"resource":{"primary":{"URL":"https:\/\/chi.scholasticahq.com\/article\/92984-the-role-of-vertebral-augmentation-procedures-in-the-management-of-multiple-myeloma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.46989\/001c.92984","relation":{},"ISSN":["2590-0048"],"issn-type":[{"value":"2590-0048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]}}}