{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T23:02:17Z","timestamp":1783897337383,"version":"3.55.0"},"reference-count":104,"publisher":"Societatea Romana de Morfologie","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:p>The association between different viruses and cancer is well acknowledged in human pathology. However, the precise understanding of how oncogenic viruses intervene in the development of cancer of salivary glands (SGs) remains incomplete. Our review aimed to explore the current literature regarding SGs cancer to evaluate the potential involvement of human papillomaviruses (HPVs) in their development. Our work hypothesis suggests that viruses may be involved in these tumors\u2019 immunogenicity. The literature analysis showed HPV-positive detection in different head and neck malignancies, added to variable risk factors and a constant increasing incidence rate. HPV tumorigenesis mechanism is complex, involving E6 and E7 HPV oncoproteins. Additionally, the reported findings generally support the relationship between SGs cancer and high oncogenic subtypes 16 and 18. However, the pathogenic contribution of HPV subtypes 11, 33, 45, 52, 56, and 59 is controversial and further research may clarify their potential involvement in the SG tumor\u2019s development. This literature review may enhance the understanding of the role of viral contribution as an etiopathogenic co-factor in SG carcinogenesis. Thus, these data may add value to innovative concepts and treatment strategies development, given that virus-induced tumors can be prevented by targeted immunization, added to oncolytic or viral therapy.<\/jats:p>","DOI":"10.47162\/rjme.65.3.02","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T11:43:48Z","timestamp":1732794228000},"page":"395-407","source":"Crossref","is-referenced-by-count":4,"title":["Are HPV oncogenic viruses involved in salivary glands tumorigenesis?"],"prefix":"10.47162","volume":"65","author":[{"name":"Department of Morphofunctional Sciences I, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin Aleodor","family":"Costin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Bianca","family":"Chifu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Morphofunctional Sciences I, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Lavinia","family":"Pricope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Morphofunctional Sciences I, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Grigora\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Morphofunctional Sciences I, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania; Department of Histopathology, Institute of Legal Medicine, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca Anca","family":"Balan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Discipline of Histology, Department of Morphological Sciences, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Pathology, Elena Doamna Clinical Hospital of Obstetrics and Gynecology, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Am\u0103linei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Morphofunctional Sciences I, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania; Department of Histopathology, Institute of Legal Medicine, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26736","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"ref0","unstructured":"\"[1] Young A, Okuyemi OT. Malignant salivary gland tumors. 2023 Jan 12. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island, FL, USA, 2024 Jan-."},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"[2] Steuer CE, Hanna GJ, Viswanathan K, Bates JE, Kaka AS, Schmitt NC, Ho AL, Saba NF. The evolving landscape of salivary gland tumors. CA Cancer J Clin, 2023, 73(6):597-619. https:\/\/doi.org\/10.3322\/caac.21807","DOI":"10.3322\/caac.21807"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"[3] van Herpen C, Vander Poorten V, Skalova A, Terhaard C, Maroldi R, van Engen A, Baujat B, Locati LD, Jensen AD, Smeele L, Hardillo J, Martineau VC, Trama A, Kinloch E, Even C, Machiels JP; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org. Salivary gland cancer: ESMO - European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up. ESMO Open, 2022, 7(6):100602. https:\/\/doi.org\/10.1016\/j.esmoop.2022.100602","DOI":"10.1016\/j.esmoop.2022.100602"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"[4] Sk\u00e1lov\u00e1 A, Hyrcza MD, Leivo I. Update from the 5th edition of the World Health Organization Classification of head and neck tumors: salivary glands. Head Neck Pathol, 2022, 16(1):40-53. https:\/\/doi.org\/10.1007\/s12105-022-01420-1","DOI":"10.1007\/s12105-022-01420-1"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"[5] Gu W, Bhangale A, Heft Neal ME, Smith JD, Brummel C, McHugh JB, Spector ME, Mills RE, Brenner JC. Analysis of human papilloma virus content and integration in mucoepidermoid carcinoma. Viruses, 2022, 14(11):2353. https:\/\/doi.org\/10.3390\/v14112353","DOI":"10.3390\/v14112353"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"[6] Reny DC, Ranasinghe VJ, Magana LC, Kaufman AC, Chalian AA, O'Malley BW Jr, Weinstein GS, Brody RM. Predictors of nodal metastasis in mucoepidermoid carcinoma of the oral cavity and oropharynx. ORL J Otorhinolaryngol Relat Spec, 2020, 82(6):327-334. https:\/\/doi.org\/10.1159\/000509142","DOI":"10.1159\/000509142"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"[7] Tasoulas J, Schrank TP, Bharambe H, Mehta J, Johnson S, Divaris K, Hackman TG, Sheth S, Kirtane K, Hernandez-Prera JC, Chung CH, Yarbrough WG, Ferrarotto R, Issaeva N, Theocharis S, Amelio AL. Molecular characterization of the salivary adenoid cystic carcinoma immune landscape by anatomic subsites. Sci Rep, 2024, 14(1):15821. https:\/\/doi.org\/10.1038\/s41598-024-66709-3","DOI":"10.1038\/s41598-024-66709-3"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"[8] Tempera I, Lieberman PM. Oncogenic viruses as entropic drivers of cancer evolution. Front Virol, 2021, 1:753366. https:\/\/doi.org\/10.3389\/fviro.2021.753366","DOI":"10.3389\/fviro.2021.753366"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"[9] H\u00fchns M, Simm G, Erbersdobler A, Zimpfer A. HPV infection, but not EBV or HHV-8 infection, is associated with salivary gland tumours. Biomed Res Int, 2015, 2015:829349. https:\/\/doi.org\/10.1155\/2015\/829349","DOI":"10.1155\/2015\/829349"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"[10] Wo\u0142\u0105cewicz M, Becht R, Grywalska E, Nied\u017awiedzka-Rystwej P. Herpesviruses in head and neck cancers. Viruses, 2020, 12(2):172. https:\/\/doi.org\/10.3390\/v12020172","DOI":"10.3390\/v12020172"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"[11] Barsouk A, Aluru JS, Rawla P, Saginala K, Barsouk A. Epidemiology, risk factors, and prevention of head and neck squamous cell carcinoma. Med Sci (Basel), 2023, 11(2):42. https:\/\/doi.org\/10.3390\/medsci11020042","DOI":"10.3390\/medsci11020042"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"[12] Rumgay H, Murphy N, Ferrari P, Soerjomataram I. Alcohol and cancer: epidemiology and biological mechanisms. Nutrients, 2021, 13(9):3173. https:\/\/doi.org\/10.3390\/nu13093173","DOI":"10.3390\/nu13093173"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"[13] Patini R, Cordaro M, Marchesini D, Scilla F, Gioco G, Rupe C, D'Agostino MA, Lajolo C. Is systemic immunosuppression a risk factor for oral cancer? A systematic review and meta-analysis. Cancers (Basel), 2023, 15(12):3077. https:\/\/doi.org\/10.3390\/cancers15123077","DOI":"10.3390\/cancers15123077"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"[14] Mat Lazim N, Yousaf A, Abusalah MAH, Sulong S, Mohd Ismail ZI, Mohamud R, Abu-Harirah HA, AlRamadneh TN, Hassan R, Abdullah B. The epigenesis of salivary glands carcinoma: from field cancerization to carcinogenesis. Cancers (Basel), 2023, 15(7):2111. https:\/\/doi.org\/10.3390\/cancers15072111","DOI":"10.3390\/cancers15072111"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"[15] Pan SY, de Groh M, Morrison H. A case-control study of risk factors for salivary gland cancer in Canada. J Cancer Epidemiol, 2017, 2017:4909214. https:\/\/doi.org\/10.1155\/2017\/4909214","DOI":"10.1155\/2017\/4909214"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"[16] Jeffers LK, Madden V, Webster-Cyriaque J. BK virus has tropism for human salivary gland cells in vitro: implications for transmission. Virology, 2009, 394(2):183-193. https:\/\/doi.org\/10.1016\/j.virol.2009.07.022","DOI":"10.1016\/j.virol.2009.07.022"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"[17] Shanehsazzadeh M, Rad JS, Pourazar A, Behbahani M. Epidemiology of herpes human virus 6 and 7 infections in salivary gland neoplasms in Isfahan, Iran. Med Arch, 2014, 68(4):276-278. https:\/\/doi.org\/10.5455\/medarh.2014.68.276-278","DOI":"10.5455\/medarh.2014.68.276-278"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"[18] Jayaraj G, Sherlin HJ, Ramani P, Premkumar P, Anuja N. Cytomegalovirus and mucoepidermoid carcinoma: a possible causal relationship? A pilot study. J Oral Maxillofac Pathol, 2015, 19(3):319-324. https:\/\/doi.org\/10.4103\/0973-029X.174618","DOI":"10.4103\/0973-029X.174618"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"[19] Stinski MF, Isomura H. Role of the cytomegalovirus major immediate early enhancer in acute infection and reactivation from latency. Med Microbiol Immunol, 2008, 197(2):223-231. https:\/\/doi.org\/10.1007\/s00430-007-0069-7","DOI":"10.1007\/s00430-007-0069-7"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"[20] Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T. Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol, 2012, 92(1):118-125. https:\/\/doi.org\/10.1016\/j.yexmp.2011.10.011","DOI":"10.1016\/j.yexmp.2011.10.011"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"[21] Harkins LE, Matlaf LA, Soroceanu L, Klemm K, Britt WJ, Wang W, Bland KI, Cobbs CS. Detection of human cytomegalovirus in normal and neoplastic breast epithelium. Herpesviridae, 2010, 1(1):8. https:\/\/doi.org\/10.1186\/2042-4280-1-8","DOI":"10.1186\/2042-4280-1-8"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"[22] Yu C, He S, Zhu W, Ru P, Ge X, Govindasamy K. Human cytomegalovirus in cancer: the mechanism of HCMV-induced carcinogenesis and its therapeutic potential. Front Cell Infect Microbiol, 2023, 13:1202138. https:\/\/doi.org\/10.3389\/fcimb.2023.1202138","DOI":"10.3389\/fcimb.2023.1202138"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"[23] Lujan B, Hakim S, Moyano S, Nadal A, Caballero M, Diaz A, Valera A, Carrera M, Cardesa A, Alos L. Activation of the EGFR\/ERK pathway in high-grade mucoepidermoid carcinomas of the salivary glands. Br J Cancer, 2010, 103(4):510-516. https:\/\/doi.org\/10.1038\/sj.bjc.6605788","DOI":"10.1038\/sj.bjc.6605788"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"[24] Akrish S, Peled M, Ben-Izhak O, Nagler RM. Malignant salivary gland tumors and cyclo-oxygenase-2: a histopathological and immunohistochemical analysis with implications on histogenesis. Oral Oncol, 2009, 45(12):1044-1050. https:\/\/doi.org\/10.1016\/j.oraloncology.2009.07.016","DOI":"10.1016\/j.oraloncology.2009.07.016"},{"key":"ref24","unstructured":"[25] Ito FA, Ito K, Coletta RD, Graner E, de Almeida OP, Lopes MA. Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67. Anal Quant Cytol Histol, 2009, 31(5):280-287."},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"[26] van den Berg AP, van der Bij W, van Son WJ, Anema J, van der Giessen M, Schirm J, Tegzess AM, The TH. Cytomegalovirus antigenemia as a useful marker of symptomatic cytomegalovirus infection after renal transplantation - a report of 130 consecutive patients. Transplantation, 1989, 48(6):991-995. https:\/\/doi.org\/10.1097\/00007890-198912000-00019","DOI":"10.1097\/00007890-198912000-00019"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"[27] Kawasaki H, Kosugi I, Arai Y, Iwashita T, Tsutsui Y. Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. PLoS One, 2011, 6(3):e17492. https:\/\/doi.org\/10.1371\/journal.pone.0017492","DOI":"10.1371\/journal.pone.0017492"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"[28] Venkateswaran L, Gan YJ, Sixbey JW, Santana VM. Epstein-Barr virus infection in salivary gland tumors in children and young adults. Cancer, 2000, 89(2):463-466. https:\/\/doi.org\/10.1002\/1097-0142(20000715)89:2<463::aid-cncr35>3.0.co;2-r","DOI":"10.1002\/1097-0142(20000715)89:2<463::AID-CNCR35>3.0.CO;2-R"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"[29] Ioachim HL, Antonescu C, Giancotti F, Dorsett B. EBV-associated primary lymphomas in salivary glands of HIV-infected patients. Pathol Res Pract, 1998, 194(2):87-95. https:\/\/doi.org\/10.1016\/S0344-0338(98)80075-7","DOI":"10.1016\/S0344-0338(98)80075-7"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"[30] Nadal D, Caduff R, Frey E, Hassam S, Zimmermann DR, Seigneurin JM, Pl\u00fcss HJ, Seger RA. Non-Hodgkin's lymphoma in four children infected with the human immunodeficiency virus. Association with Epstein-Barr virus and treatment. Cancer, 1994, 73(1):224-230. https:\/\/doi.org\/10.1002\/1097-0142(19940101)73:1<224::aid-cncr2820730138>3.0.co;2-d","DOI":"10.1002\/1097-0142(19940101)73:1<224::AID-CNCR2820730138>3.0.CO;2-D"},{"key":"ref30","unstructured":"[31] Prabhu SR, Wilson DF. Evidence of Epstein-Barr virus association with head and neck cancers: a review. J Can Dent Assoc, 2016, 82:g2."},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"[32] Zhou X, Zhu C, Li H. BK polyomavirus: latency, reactivation, diseases and tumorigenesis. Front Cell Infect Microbiol, 2023, 13:1263983. https:\/\/doi.org\/10.3389\/fcimb.2023.1263983","DOI":"10.3389\/fcimb.2023.1263983"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"[33] Tognon M, Corallini A, Martini F, Negrini M, Barbanti-Brodano G. Oncogenic transformation by BK virus and association with human tumors. Oncogene, 2003, 22(33):5192-5200. https:\/\/doi.org\/10.1038\/sj.onc.1206550","DOI":"10.1038\/sj.onc.1206550"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"[34] Qian X, Kaufmann AM, Chen C, Tzamalis G, Hofmann VM, Keilholz U, Hummel M, Albers AE. Prevalence and associated survival of high-risk HPV-related adenoid cystic carcinoma of the salivary glands. Int J Oncol, 2016, 49(2):803-811. https:\/\/doi.org\/10.3892\/ijo.2016.3563","DOI":"10.3892\/ijo.2016.3563"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"[35] Di Luca D, Mirandola P, Ravaioli T, Dolcetti R, Frigatti A, Bovenzi P, Sighinolfi L, Monini P, Cassai E. Human herpes-viruses 6 and 7 in salivary glands and shedding in saliva of healthy and human immunodeficiency virus positive individuals. J Med Virol, 1995, 45(4):462-468. https:\/\/doi.org\/10.1002\/jmv.1890450418","DOI":"10.1002\/jmv.1890450418"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"[36] Balhara N, Yadav R, Ranga S, Ahuja P, Tanwar M. Understanding the HPV associated cancers: a comprehensive review. Mol Biol Rep, 2024, 51(1):743. https:\/\/doi.org\/10.1007\/s11033-024-09680-6","DOI":"10.1007\/s11033-024-09680-6"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"[37] Egawa N. Papillomaviruses and cancer: commonalities and differences in HPV carcinogenesis at different sites of the body. Int J Clin Oncol, 2023, 28(8):956-964. https:\/\/doi.org\/10.1007\/s10147-023-02340-y","DOI":"10.1007\/s10147-023-02340-y"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"[38] Teng WQ, Chen XP, Xue XC, Zhang Y, Tan XJ, Sun G, Wang Y, Wang L. Distribution of 37 human papillomavirus types in parotid gland tumor tissues. Oncol Lett, 2014, 7(3):834-838. https:\/\/doi.org\/10.3892\/ol.2013.1770","DOI":"10.3892\/ol.2013.1770"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"[39] Vageli D, Sourvinos G, Ioannou M, Koukoulis GK, Spandidos DA. High-risk human papillomavirus (HPV) in parotid lesions. Int J Biol Markers, 2007, 22(4):239-244. https:\/\/doi.org\/10.1177\/172460080702200401","DOI":"10.1177\/172460080702200401"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"[40] Lin FCF, Chen PL, Tsao TY, Li CR, Jeng KC, Tsai SCS. Prevalence of human papillomavirus and Epstein-Barr virus in salivary gland diseases. J Int Med Res, 2014, 42(5):1093-1101. https:\/\/doi.org\/10.1177\/0300060514543041","DOI":"10.1177\/0300060514543041"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"[41] Joseph AW, D'Souza G. Epidemiology of human papillomavirus-related head and neck cancer. Otolaryngol Clin North Am, 2012, 45(4):739-764. https:\/\/doi.org\/10.1016\/j.otc.2012.04.003","DOI":"10.1016\/j.otc.2012.04.003"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"[42] Porcheri C, Meisel CT, Mitsiadis TA. Molecular and cellular modelling of salivary gland tumors open new landscapes in diagnosis and treatment. Cancers (Basel), 2020, 12(11):3107. https:\/\/doi.org\/10.3390\/cancers12113107","DOI":"10.3390\/cancers12113107"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"[43] Stenner M, Klussmann JP. Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved. Eur Arch Otorhinolaryngol, 2009, 266(3):333-341. https:\/\/doi.org\/10.1007\/s00405-008-0882-7","DOI":"10.1007\/s00405-008-0882-7"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"[44] Isayeva T, Said-Al-Naief N, Ren Z, Li R, Gnepp D, Brandwein-Gensler M. Salivary mucoepidermoid carcinoma: demonstration of transcriptionally active human papillomavirus 16\/18. Head Neck Pathol, 2013, 7(2):135-148. https:\/\/doi.org\/10.1007\/s12105-012-0411-2","DOI":"10.1007\/s12105-012-0411-2"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"[45] Boland JM, McPhail ED, Garc\u00eda JJ, Lewis JE, Schembri-Wismayer DJ. Detection of human papilloma virus and p16 expression in high-grade adenoid cystic carcinoma of the head and neck. Mod Pathol, 2012, 25(4):529-536. https:\/\/doi.org\/10.1038\/modpathol.2011.186","DOI":"10.1038\/modpathol.2011.186"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"[46] Mckenzie J, Lockyer J, Singh T, Nguyen E. Salivary gland tumours: an epidemiological review of non-neoplastic and neoplastic pathology. Br J Oral Maxillofac Surg, 2023, 61(1):12-18. https:\/\/doi.org\/10.1016\/j.bjoms.2022.11.281","DOI":"10.1016\/j.bjoms.2022.11.281"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"[47] Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev, 2003, 16(1):1-17. https:\/\/doi.org\/10.1128\/CMR.16.1.1-17.2003","DOI":"10.1128\/CMR.16.1.1-17.2003"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"[48] Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, Jiang B, Goodman MT, Sibug-Saber M, Cozen W, Liu L, Lynch CF, Wentzensen N, Jordan RC, Altekruse S, Anderson WF, Rosenberg PS, Gillison ML. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol, 2023, 41(17):3081-3088. https:\/\/doi.org\/10.1200\/JCO.22.02625","DOI":"10.1200\/JCO.22.02625"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"[49] Roman BR, Aragones A. Epidemiology and incidence of HPV-related cancers of the head and neck. J Surg Oncol, 2021, 124(6):920-922. https:\/\/doi.org\/10.1002\/jso.26687","DOI":"10.1002\/jso.26687"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"[50] Oliveira AC, Cavalcanti de Lima IC, Frez Marques VM, Alves de Ara\u00fajo WH, de Campos Ferreira C. Human papillomavirus prevalence in oral and oropharyngeal squamous cell carcinoma in South America: a systematic review and meta-analysis. Oncol Rev, 2022, 16(1):552. https:\/\/doi.org\/10.4081\/oncol.2022.552","DOI":"10.4081\/oncol.2022.552"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"[51] Bishop JA, Yonescu R, Batista D, Yemelyanova A, Ha PK, Westra WH. Mucoepidermoid carcinoma does not harbor transcriptionally active high risk human papillomavirus even in the absence of the MAML2 translocation. Head Neck Pathol, 2014, 8(3):298-302. https:\/\/doi.org\/10.1007\/s12105-014-0541-9","DOI":"10.1007\/s12105-014-0541-9"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"[52] Zhang Y, Fakhry C, D'Souza G. Projected association of human papillomavirus vaccination with oropharynx cancer incidence in the US, 2020-2045. JAMA Oncol, 2021, 7(10):e212907. https:\/\/doi.org\/10.1001\/jamaoncol.2021.2907","DOI":"10.1001\/jamaoncol.2021.2907"},{"key":"ref52","unstructured":"[53] Global Cancer Observatory (GCO). Cancer Today: data visualization tools. World Health Organization (WHO), International Agency for Research on Cancer (IARC), Lyon, France, 2020."},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"[54] Syrj\u00e4nen S. Oral manifestations of human papillomavirus infections. Eur J Oral Sci, 2018, 126(Suppl 1):49-66. https:\/\/doi.org\/10.1111\/eos.12538","DOI":"10.1111\/eos.12538"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"[55] Choi YJ, Park JS. Clinical significance of human papillomavirus genotyping. J Gynecol Oncol, 2016, 27(2):e21. https:\/\/doi.org\/10.3802\/jgo.2016.27.e21","DOI":"10.3802\/jgo.2016.27.e21"},{"key":"ref55","unstructured":"[56] Luria L, Cardoza-Favarato G. Human papillomavirus. 2023 Jan 16. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island, FL, USA, 2024 Jan-."},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"[57] Dacus D, Stancic S, Pollina SR, Rifrogiate E, Palinski R, Wallace NA. Beta human papillomavirus 8 E6 induces micronucleus formation and promotes chromothripsis. J Virol, 2022, 96(19):e0101522. https:\/\/doi.org\/https:\/\/doi.org\/10.1128\/jvi.01015-22","DOI":"10.1128\/jvi.01015-22"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"[58] Chatterjee N, Sultana F, Roy R, Dey S, Naskar S, Dam A, Bhowmick AK, Begum R, Mandal SS, Mandal RK, Chakrabarti J, Panda CK, Tommasino M, Gheit T, Dutta S. Prevalence of novel gamma HPV types 223 and 225 in oral cavity and skin of Indian normal and neoplastic participants. J Med Virol, 2023, 95(8):e29019. https:\/\/doi.org\/10.1002\/jmv.29019","DOI":"10.1002\/jmv.29019"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"[59] Ghittoni R, Accardi R, Chiocca S, Tommasino M. Role of human papillomaviruses in carcinogenesis. Ecancermedicalscience, 2015, 9:526. https:\/\/doi.org\/10.3332\/ecancer.2015.526","DOI":"10.3332\/ecancer.2015.526"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"[60] Senba M, Mori N. Mechanisms of virus immune evasion lead to development from chronic inflammation to cancer formation associated with human papillomavirus infection. Oncol Rev, 2012, 6(2):e17. https:\/\/doi.org\/10.4081\/oncol.2012.e17","DOI":"10.4081\/oncol.2012.e17"},{"key":"ref60","unstructured":"[61] Balan R, Simion N, Giu\u015fc\u0103 SE, Grigora\u015f A, Gheuc\u0103-Solov\u0103stru L, Gheorghi\u0163\u0103 V, Am\u0103linei C, C\u0103runtu ID. Immunohistochemical assessment of p16, COX-2 and EGFR in HPV-positive cervical squamous intraepithelial lesions. Rom J Morphol Embryol, 2011, 52(4):1187-1194."},{"key":"ref61","doi-asserted-by":"publisher","unstructured":"[62] Chatterjee S, Starrett GJ. Microhomology-mediated repair machinery and its relationship with HPV-mediated oncogenesis. J Med Virol, 2024, 96(5):e29674. https:\/\/doi.org\/10.1002\/jmv.29674","DOI":"10.1002\/jmv.29674"},{"key":"ref62","doi-asserted-by":"publisher","unstructured":"[63] Basukala O, Trejo-Cerro O, Myers MP, Pim D, Massimi P, Thomas M, Guarnaccia C, Owen D, Banks L. HPV-16 E7 interacts with the endocytic machinery via the AP2 adaptor \u03bc2 subunit. mBio, 2022, 13(6):e0230222. https:\/\/doi.org\/10.1128\/mbio.02302-22","DOI":"10.1128\/mbio.02302-22"},{"key":"ref63","doi-asserted-by":"publisher","unstructured":"[64] Giarr\u00e8 M, Caldeira S, Malanchi I, Ciccolini F, Le\u00e3o MJ, Tommasino M. Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle arrest. J Virol, 2001, 75(10):4705-4712. https:\/\/doi.org\/10.1128\/JVI.75.10.4705-4712.2001","DOI":"10.1128\/JVI.75.10.4705-4712.2001"},{"key":"ref64","doi-asserted-by":"publisher","unstructured":"[65] Squarzanti DF, Sorrentino R, Landini MM, Chiesa A, Pinato S, Rocchio F, Mattii M, Penengo L, Azzimonti B. Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response. Virol J, 2018, 15(1):176. https:\/\/doi.org\/10.1186\/s12985-018-1086-4","DOI":"10.1186\/s12985-018-1086-4"},{"key":"ref65","doi-asserted-by":"publisher","unstructured":"[66] Yokota T. Is biomarker research advancing in the era of personalized medicine for head and neck cancer? Int J Clin Oncol, 2014, 19(2):211-219. https:\/\/doi.org\/10.1007\/s10147-013-0660-4","DOI":"10.1007\/s10147-013-0660-4"},{"key":"ref66","doi-asserted-by":"publisher","unstructured":"[67] Lehoux M, D'Abramo CM, Archambault J. Molecular mechanisms of human papillomavirus-induced carcinogenesis. Public Health Genomics, 2009, 12(5-6):268-280. https:\/\/doi.org\/10.1159\/000214918","DOI":"10.1159\/000214918"},{"key":"ref67","doi-asserted-by":"publisher","unstructured":"[68] Wang JCK, Baddock HT, Mafi A, Foe IT, Bratkowski M, Lin TY, Jensvold ZD, Preciado L\u00f3pez M, Stokoe D, Eaton D, Hao Q, Nile AH. Structure of the p53 degradation complex from HPV16. Nat Commun, 2024, 15(1):1842. https:\/\/doi.org\/10.1038\/s41467-024-45920-w","DOI":"10.1038\/s41467-024-45920-w"},{"key":"ref68","doi-asserted-by":"publisher","unstructured":"[69] Cosper PF, Hrycyniak LCF, Paracha M, Lee DL, Wan J, Jones K, Bice SA, Nickel K, Mallick S, Taylor AM, Kimple RJ, Lambert PF, Weaver BA. HPV16 E6 induces chromosomal instability due to polar chromosomes caused by E6AP-dependent degradation of the mitotic kinesin CENP-E. Proc Natl Acad Sci U S A, 2023, 120(14):e2216700120. https:\/\/doi.org\/10.1073\/pnas.2216700120","DOI":"10.1073\/pnas.2216700120"},{"key":"ref69","doi-asserted-by":"publisher","unstructured":"[70] Graham SV. The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review. Clin Sci (Lond), 2017, 131(17):2201-2221. https:\/\/doi.org\/10.1042\/CS20160786","DOI":"10.1042\/CS20160786"},{"key":"ref70","doi-asserted-by":"publisher","unstructured":"[71] Descamps G, Duray A, Delvenne P, Saussez S. Chapter 10: Implications of human papillomavirus infections in the biology of head and neck cancers. In: Vanden Broeck D (ed). Human papillomavirus and related diseases: from bench to bedside - a clinical perspective. IntechOpen Ltd., London, UK, 2012, 222-278. https:\/\/doi.org\/10.5772\/29999","DOI":"10.5772\/29999"},{"key":"ref71","doi-asserted-by":"publisher","unstructured":"[72] Lechner M, Liu J, Masterson L, Fenton TR. HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management. Nat Rev Clin Oncol, 2022, 19(5):306-327. https:\/\/doi.org\/10.1038\/s41571-022-00603-7","DOI":"10.1038\/s41571-022-00603-7"},{"key":"ref72","doi-asserted-by":"publisher","unstructured":"[73] Tahari AK, Alluri KC, Quon H, Koch W, Wahl RL, Subramaniam RM. FDG PET\/CT imaging of oropharyngeal squamous cell carcinoma: characteristics of human papillomavirus-positive and -negative tumors. Clin Nucl Med, 2014, 39(3):225-231. https:\/\/doi.org\/10.1097\/RLU.0000000000000255","DOI":"10.1097\/RLU.0000000000000255"},{"key":"ref73","doi-asserted-by":"publisher","unstructured":"[74] Syrj\u00e4nen S. Human papillomavirus infections and oral tumors. Med Microbiol Immunol, 2003, 192(3):123-128. https:\/\/doi.org\/10.1007\/s00430-002-0173-7","DOI":"10.1007\/s00430-002-0173-7"},{"key":"ref74","doi-asserted-by":"publisher","unstructured":"[75] Zhang L, Wu J, Ling MT, Zhao L, Zhao KN. The role of the PI3K\/Akt\/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses. Mol Cancer, 2015, 14:87. https:\/\/doi.org\/10.1186\/s12943-015-0361-x","DOI":"10.1186\/s12943-015-0361-x"},{"key":"ref75","doi-asserted-by":"publisher","unstructured":"[76] Williams VM, Filippova M, Soto U, Duerksen-Hughes PJ. HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress. Future Virol, 2011, 6(1):45-57. https:\/\/doi.org\/10.2217\/fvl.10.73","DOI":"10.2217\/fvl.10.73"},{"key":"ref76","doi-asserted-by":"publisher","unstructured":"[77] Yin LX, Ha PK. Genetic alterations in salivary gland cancers. Cancer, 2016, 122(12):1822-1831. https:\/\/doi.org\/10.1002\/cncr.29890","DOI":"10.1002\/cncr.29890"},{"key":"ref77","doi-asserted-by":"publisher","unstructured":"[78] Blanco R, Carrillo-Beltr\u00e1n D, Corval\u00e1n AH, Aguayo F. High-risk human papillomavirus and Epstein-Barr virus coinfection: a potential role in head and neck carcinogenesis. Biology (Basel), 2021, 10(12):1232. https:\/\/doi.org\/10.3390\/biology10121232","DOI":"10.3390\/biology10121232"},{"key":"ref78","doi-asserted-by":"publisher","unstructured":"[79] Bendtsen SK, Jakobsen KK, Carlander ALF, Gr\u00f8nh\u00f8j C, von Buchwald C. Focal epithelial hyperplasia. Viruses, 2021, 13(8):1529. https:\/\/doi.org\/10.3390\/v13081529","DOI":"10.3390\/v13081529"},{"key":"ref79","doi-asserted-by":"publisher","unstructured":"[80] Kurita T, Chitose SI, Sato K, Sakazaki T, Fukahori M, Sueyoshi S, Umeno H. Pathological mechanisms of laryngeal papillomatosis based on laryngeal epithelial characteristics. Laryngoscope Investig Otolaryngol, 2019, 4(1):89-94. https:\/\/doi.org\/10.1002\/lio2.242","DOI":"10.1002\/lio2.242"},{"key":"ref80","doi-asserted-by":"publisher","unstructured":"[81] Gemigniani F, Hern\u00e1ndez-Losa J, Ferrer B, Garc\u00eda-Patos V. Focal epithelial hyperplasia by human papillomavirus (HPV)-32 misdiagnosed as HPV-16 and treated with combination of retinoids, imiquimod and quadrivalent HPV vaccine. J Dermatol, 2015, 42(12):1172-1175. https:\/\/doi.org\/10.1111\/1346-8138.12967","DOI":"10.1111\/1346-8138.12967"},{"key":"ref81","doi-asserted-by":"publisher","unstructured":"[82] Brunner M, Koperek O, Wrba F, Erovic BM, Heiduschka G, Schoppper C, Thurnher D. HPV infection and p16 expression in carcinomas of the minor salivary glands. Eur Arch Otorhinolaryngol, 2012, 269(10):2265-2269. https:\/\/doi.org\/10.1007\/s00405-011-1894-2","DOI":"10.1007\/s00405-011-1894-2"},{"key":"ref82","doi-asserted-by":"publisher","unstructured":"[83] Padhi SS, Roy S, Kar M, Saha A, Roy S, Adhya A, Baisakh M, Banerjee B. Role of CDKN2A\/p16 expression in the prognostication of oral squamous cell carcinoma. Oral Oncol, 2017, 73:27-35. https:\/\/doi.org\/10.1016\/j.oraloncology.2017.07.030","DOI":"10.1016\/j.oraloncology.2017.07.030"},{"key":"ref83","doi-asserted-by":"publisher","unstructured":"[84] Singhi AD, Westra WH. Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. Cancer, 2010, 116(9):2166-2173. https:\/\/doi.org\/10.1002\/cncr.25033","DOI":"10.1002\/cncr.25033"},{"key":"ref84","doi-asserted-by":"publisher","unstructured":"[85] Allegra E, Bianco MR, Mignogna C, Caltabiano R, Grasso M, Puzzo L. Role of p16 expression in the prognosis of patients with laryngeal cancer: a single retrospective analysis. Cancer Control, 2021, 28:10732748211033544. https:\/\/doi.org\/10.1177\/10732748211033544","DOI":"10.1177\/10732748211033544"},{"key":"ref85","doi-asserted-by":"publisher","unstructured":"[86] Suman S, Sharma R, Katiyar V, Mahajan S, Suri A, Sharma MC, Sarkar C, Suri V. Role of CDKN2A deletion in grade 2\/3 IDH-mutant astrocytomas: need for selective approach in resource-constrained settings. Neurosurg Focus, 2022, 53(6):E17. https:\/\/doi.org\/10.3171\/2022.9.FOCUS22427","DOI":"10.3171\/2022.9.FOCUS22427"},{"key":"ref86","doi-asserted-by":"publisher","unstructured":"[87] Stephen JK, Divine G, Chen KM, Chitale D, Havard S, Worsham MJ. Significance of p16 in site-specific HPV positive and HPV negative head and neck squamous cell carcinoma. Cancer Clin Oncol, 2013, 2(1):51-61. https:\/\/doi.org\/10.5539\/cco.v2n1p51","DOI":"10.5539\/cco.v2n1p51"},{"key":"ref87","doi-asserted-by":"publisher","unstructured":"[88] Haeggblom L, Ursu RG, Mirzaie L, Attoff T, Gahm C, Nordenvall LH, N\u00e4sman A. No evidence for human papillomavirus having a causal role in salivary gland tumors. Diagn Pathol, 2018, 13(1):44. https:\/\/doi.org\/10.1186\/s13000-018-0721-0","DOI":"10.1186\/s13000-018-0721-0"},{"key":"ref88","doi-asserted-by":"publisher","unstructured":"[89] Mohamed FE, Aldayem LN, Hemaida MA, Siddig O, Osman ZH, Shafig IR, Salih MAM, Muneer MS, Hassan R, Ahmed ES, Hassan LA, Bakheet OEH, Edris AMM, Ahmed A, Mohamed NS, Siddig EE. Molecular detection of human papillomavirus-16 among Sudanese patients diagnosed with squamous cell carcinoma and salivary gland carcinoma. BMC Res Notes, 2021, 14(1):56. https:\/\/doi.org\/10.1186\/s13104-021-05471-5","DOI":"10.1186\/s13104-021-05471-5"},{"key":"ref89","doi-asserted-by":"publisher","unstructured":"[90] H\u00e4metoja H, Hagstr\u00f6m J, Haglund C, B\u00e4ck L, M\u00e4kitie A, Syrj\u00e4nen S. Polyomavirus JCPyV infrequently detectable in adenoid cystic carcinoma of the oral cavity and the airways. Virchows Arch, 2019, 475(5):609-616. https:\/\/doi.org\/10.1007\/s00428-019-02617-6","DOI":"10.1007\/s00428-019-02617-6"},{"key":"ref90","unstructured":"[91] Descamps G, Duray A, Rodriguez A, Chantrain G, Depuydt CE, Delvenne P, Saussez S. Detection and quantification of human papillomavirus in benign and malignant parotid lesions. Anticancer Res, 2012, 32(9):3929-3932."},{"key":"ref91","doi-asserted-by":"publisher","unstructured":"[92] Teymoortash A, Bohne F, Jonsdottir T, Hoch S, Eivazi B, Roessler M, Werner JA, Mandic R. Human papilloma virus (HPV) is not implicated in the etiology of Warthin's tumor of the parotid gland. Acta Otolaryngol, 2013, 133(9):972-976. https:\/\/doi.org\/10.3109\/00016489.2013.797603","DOI":"10.3109\/00016489.2013.797603"},{"key":"ref92","unstructured":"[93] Sk\u00e1lov\u00e1 A, Ka\u0161p\u00edrkov\u00e1 J, Andrle P, Hosti\u010dka L, Vane\u010dek T. Human papillomaviruses are not involved in the etiopathogenesis of salivary gland tumors. Cesk Patol, 2013, 49(2):72-75."},{"key":"ref93","doi-asserted-by":"publisher","unstructured":"[94] Cantley RL, Gabrielli E, Montebelli F, Cimbaluk D, Gattuso P, Petruzzelli G. Ancillary studies in determining human papillomavirus status of squamous cell carcinoma of the oropharynx: a review. Pathol Res Int, 2011, 2011:138469. https:\/\/doi.org\/10.4061\/2011\/138469","DOI":"10.4061\/2011\/138469"},{"key":"ref94","doi-asserted-by":"publisher","unstructured":"[95] Hafed L, Farag H, Shaker O, El-Rouby D. Is human papilloma virus associated with salivary gland neoplasms? An in situ-hybridization study. Arch Oral Biol, 2012, 57(9):1194-1199. https:\/\/doi.org\/10.1016\/j.archoralbio.2012.03.009","DOI":"10.1016\/j.archoralbio.2012.03.009"},{"key":"ref95","doi-asserted-by":"publisher","unstructured":"[96] Morais MLSA, Azevedo PR, Carvalho CH, Medeiros L, Lajus T, Costa ALL. Clinicopathological study of salivary gland tumors: an assessment of 303 patients. Cad Saude Publica, 2011, 27(5):1035-1040. https:\/\/doi.org\/10.1590\/s0102-311x2011000500020","DOI":"10.1590\/S0102-311X2011000500020"},{"key":"ref96","doi-asserted-by":"publisher","unstructured":"[97] Harada H, Matsumoto H, Nakatsuka SI, Kurose A. Lymphoepithelial carcinoma of the parotid gland: a unique example showing p16 immunoreactivity. Med Mol Morphol, 2021, 54(4):368-373. https:\/\/doi.org\/10.1007\/s00795-021-00295-5","DOI":"10.1007\/s00795-021-00295-5"},{"key":"ref97","doi-asserted-by":"publisher","unstructured":"[98] Hu H, Jiang H, Zhu Z, Yin H, Liu K, Chen L, Zhao M, Yu Z. Analysis of the anatomical distribution of HPV genotypes in head and neck squamous papillomas. PLoS One, 2023, 18(8):e0290004. https:\/\/doi.org\/10.1371\/journal.pone.0290004","DOI":"10.1371\/journal.pone.0290004"},{"key":"ref98","doi-asserted-by":"publisher","unstructured":"[99] Hidalgo-Tenorio C, Calle-G\u00f3mez I, Moya-Meg\u00edas R, Rodr\u00edguez-Granges J, Omar M, L\u00f3pez Hidalgo J, Garc\u00eda-Mart\u00ednez C. HPV infection of the oropharyngeal, genital and anal mucosa and associated dysplasia in people living with HIV. Viruses, 2023, 15(5):1170. https:\/\/doi.org\/10.3390\/v15051170","DOI":"10.3390\/v15051170"},{"key":"ref99","doi-asserted-by":"publisher","unstructured":"[100] Liu X, Ma X, Lei Z, Feng H, Wang S, Cen X, Gao S, Jiang Y, Jiang J, Chen Q, Tang Y, Tang Y, Liang X. Chronic inflammation-related HPV: a driving force speeds oropharyngeal carcinogenesis. PLoS One, 2015, 10(7):e0133681. https:\/\/doi.org\/10.1371\/journal.pone.0133681","DOI":"10.1371\/journal.pone.0133681"},{"key":"ref100","doi-asserted-by":"publisher","unstructured":"[101] Tanzawa A, Saito K, Ota M, Takahashi K, Ohno I, Hanazawa T, Uzawa K, Takiguchi Y. Salivary gland-type cancers: cross-organ demographics of a rare cancer. Int J Clin Oncol, 2024, 29(6):755-763. https:\/\/doi.org\/10.1007\/s10147-024-02505-3","DOI":"10.1007\/s10147-024-02505-3"},{"key":"ref101","doi-asserted-by":"publisher","unstructured":"[102] Trigo J, Garc\u00eda-Cos\u00edo M, Garc\u00eda-Casta\u00f1o A, Gom\u00e0 M, Mesia-Nin R, Ruiz-Bravo E, Soria-Rivas A, Castillo P, Bra\u00f1a-Garc\u00eda I, Alberola-Ferranti M. Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology. Clin Transl Oncol, 2022, 24(10):1890-1902. https:\/\/doi.org\/10.1007\/s12094-022-02856-1","DOI":"10.1007\/s12094-022-02856-1"},{"key":"ref102","doi-asserted-by":"publisher","unstructured":"[103] Krauss C, Wagner S, Klu\u00dfmann JP, Pons-K\u00fchnemann J, Arens C, Langer C, Wittekindt C. Speicheldr\u00fcsenkarzinome - Monozentrische Erfahrung zu Subtypen und deren Inzidenz \u00fcber 42 Jahre [Salivary gland carcinomas - monocentric experience on subtypes and their incidences over 42 years]. Laryngorhinootologie, 2023, 102(7):512-520. https:\/\/doi.org\/10.1055\/a-1976-9694","DOI":"10.1055\/a-1976-9694"},{"key":"ref103","doi-asserted-by":"publisher","unstructured":"[104] Krishnan K, Chen T, Paster BJ, A practical guide to the oral microbiome and its relation to health and disease. 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