{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:41:23Z","timestamp":1780051283261,"version":"3.53.1"},"reference-count":46,"publisher":"Societatea Romana de Morfologie","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:p>Metastases are the most common tumors of the spine. As an important increase in the annual incidence of spinal metastases (SMs) has been observed in the last decade, the aim of this study was to describe the epidemiology and histopathological types of SMs surgically treated in the Neurosurgery Clinics of a Regional Hospital in North-Eastern Romania over a period of five years, in order to define a certain tumor profile that would benefit from an early screening. We retrospectively evaluated 115 adult patients, searching for demographic data (gender and age of the patients), primary tumor characteristics (location and histological type), topography of the SMs, and the time interval between the diagnosis of the primary tumor and the surgery for the SMs. The patients were elderly (average age: 58.96 years), with a male predominance (67.82%). Main location of SMs was in thoracic region (44.34%), with multiple vertebral metastases in 30.43% of patients. Only 33.04% of the patients had a known cancer at the time of admission. Primary tumor was located mainly in lung (47.82%), gastrointestinal tract (15.65%), breast (11.30%), prostate (10.43%) and kidney (9.56%). SMs from lung cancer (LC) mostly expressed squamous cell carcinoma (19.13%), probably due to patients\u2019 smoking habits, and those from the digestive system mostly exhibited a moderately\/poor colorectal adenocarcinoma (8.69%). Our data suggest the need for close surveillance of patients diagnosed with LC and colorectal cancer because these malignancies most frequently develop SMs. Smoking prevention actions and screening programs for the detection and removal of precancerous colorectal lesions must be developed and expanded.<\/jats:p>","DOI":"10.47162\/rjme.65.3.10","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T11:43:48Z","timestamp":1732794228000},"page":"481-492","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of epidemiological and pathological features of symptomatic spinal metastases in Romania \u2013 what could we learn from a retrospective study?"],"prefix":"10.47162","volume":"65","author":[{"name":"Doctoral School, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015etefan","family":"\u015eelaru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian","family":"Eva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Neurosurgery Clinics, Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Ia\u015fi, Romania; Department of Neurology and Neurosurgery, Apollonia University of Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Sava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Morpho-Functional Sciences I, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania; Department of Pathology, Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Floren\u0163a","family":"Dumitrescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pathology, Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius Gabriel","family":"Dabija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Neurosurgery Clinics, Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Ia\u015fi, Romania; Department of Surgery II, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Poroch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Palliative Care, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania; Palliative Oncological Clinic, Regional Institute of Oncology, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Knieling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Morpho-Functional Sciences I, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania; Institute of Forensic Medicine, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristinel Ionel","family":"Stan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Morpho-Functional Sciences I, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Corina","family":"Dima-Cozma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Medical Specialties I, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26736","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"ref0","unstructured":"\"[1] Ziu E, Viswanathan VK, Mesfin FB. Spinal metastasis. 2023 Aug 14. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island, FL, USA, 2024 Jan-."},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"[2] Cerqueira BP, dos Santos do Nascimento Carvalho M, de Barros Pontes FG. Epidemiological characterization of patients with spinal tumors in Alagoas, Brazil [Perfil epidemiol\u00f3gico de pacientes com tumores da coluna vertebral em Alagoas, Brasil]. 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