{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:34:31Z","timestamp":1781620471050,"version":"3.54.5"},"reference-count":35,"publisher":"Societatea Romana de Morfologie","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:p>Aim: In this secondary analysis, we aimed to characterize the lymphocytes population and placental inflammation in pregnant women with moderate and severe coronavirus disease 2019 (COVID-19) forms. Patients, Materials and Methods: In the analysis of this prospective evaluation, we included 26 pregnant women at term with moderate and severe COVID-19 forms that were evaluated in a tertiary maternity center in a one-year timeframe. Clinical data, along with blood immunophenotyping results and placental histopathological examinations were comparatively evaluated between two study groups depending on the COVID-19 severity: Group 1 (moderate COVID-19, n=14 patients) and Group 2 (severe COVID-19, n=12 patients). Results: Pregnant patients with severe COVID-19 presented significantly lower total amount of lymphocytes (p 0.001), T-lymphocytes (p=0.009), cluster of differentiation (CD)4+ T-cells (p=0.002), B-lymphocytes (p=0.001). Also, the number of CD4+ T-cells (p=0.01), CD8+ T-cells (p=0.02) and B-lymphocytes (p=0.002) was lower enough for cases with severe COVID-19. Conclusions: Lymphocytopenia could be a useful hematological marker for risk stratification of COVID-19 in pregnant women at term. A vertical transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cannot be confirmed in this study, mainly because of the limited sample size and short timeframe between infection and birth.<\/jats:p>","DOI":"10.47162\/rjme.65.3.11","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T11:43:48Z","timestamp":1732794228000},"page":"493-498","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the lymphocyte population and placental inflammation in pregnant patients with moderate or severe COVID-19 forms \u2013 a secondary analysis"],"prefix":"10.47162","volume":"65","author":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina Elena","family":"T\u0103nase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca Anamaria","family":"Mogo\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania; Doctoral School, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona Juliette","family":"Mogo\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Endocrinology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015etefana Raluca","family":"Bran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PhD Student, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor C\u0103t\u0103lin","family":"G\u00eesc\u0103","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania; Doctoral School, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iustina Petra","family":"Solomon-Condriuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania; Doctoral School, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Florida","family":"Costea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery II, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Valentin","family":"T\u0103nase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Anesthesiology and Intensive Care, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei Ionu\u0163","family":"Cucu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Biomedical Sciences, Faculty of Medicine and Biological Sciences, \u015etefan cel Mare University of Suceava, Romania; 2nd Neurosurgery Clinic, Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26736","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Ozer E, Cagliyan E, Yuzuguldu RI, Cevizci MC, Duman N. Villitis of unknown etiology in the placenta of a pregnancy complicated by COVID-19. Turk Patoloji Derg, 2021, 37(2):167-171. https:\/\/doi.org\/10.5146\/tjpath.2020.01506","DOI":"10.5146\/tjpath.2020.01506"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"[2] Adam AM, Vasilache IA, Socolov D, Stuparu Cretu M, Georgescu CV, Vicoveanu P, Mihalceanu E, Harabor A, Socolov R. Risk factors associated with severe disease and intensive care unit admission of pregnant patients with COVID-19 infection - a retrospective study. J Clin Med, 2022, 11(20):6055. https:\/\/doi.org\/10.3390\/jcm11206055","DOI":"10.3390\/jcm11206055"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"[3] Adam AM, Popa RF, Vaduva C, Georgescu CV, Adam G, Melinte-Popescu AS, Popa C, Socolov D, Nechita A, Vasilache IA, Mihalceanu E, Harabor AM, Melinte-Popescu M, Harabor V, Neagu A, Socolov R. Pregnancy outcomes, immunophenotyping and immunohistochemical findings in a cohort of pregnant patients with COVID-19 - a prospective study. Diagnostics (Basel), 2023, 13(7):1345. https:\/\/doi.org\/10.3390\/diagnostics13071345","DOI":"10.3390\/diagnostics13071345"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"[4] Timpau AS, Miftode RS, Costache II, Petris AO, Miftode IL, Gheorghe L, Timpau R, Miftode ID, Prepeliuc CS, Coman I, Anton-Paduraru DT, Tuchilus C, Miftode EG. An overview of the impact of bacterial infections and the associated mortality predictors in patients with COVID-19 admitted to a tertiary center from Eastern Europe. Antibiotics (Basel), 2023, 12(1):144. https:\/\/doi.org\/10.3390\/antibiotics12010144","DOI":"10.3390\/antibiotics12010144"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"[5] Volovat SR, Ursulescu CL, Moisii LG, Volovat C, Boboc D, Scripcariu D, Amurariti F, Stefanescu C, Stolniceanu CR, Agop M, Lungulescu C, Volov\u0103\u0163 CC. The landscape of nanovectors for modulation in cancer immunotherapy. Pharmaceutics, 2022, 14(2):397. https:\/\/doi.org\/10.3390\/pharmaceutics14020397","DOI":"10.3390\/pharmaceutics14020397"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"[6] Bonaventura A, Vecchi\u00e9 A, Dagna L, Martinod K, Dixon DL, Van Tassell BW, Dentali F, Montecucco F, Massberg S, Levi M, Abbate A. Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nat Rev Immunol, 2021, 21(5):319-329. https:\/\/doi.org\/10.1038\/s41577-021-00536-9","DOI":"10.1038\/s41577-021-00536-9"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"[7] Gusev E, Sarapultsev A, Solomatina L, Chereshnev V. SARS-CoV-2-specific immune response and the pathogenesis of COVID-19. Int J Mol Sci, 2022, 23(3):1716. https:\/\/doi.org\/10.3390\/ijms23031716","DOI":"10.3390\/ijms23031716"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"[8] Birnhuber A, Flie\u00dfer E, Gorkiewicz G, Zacharias M, Seeliger B, David S, Welte T, Schmidt J, Olschewski H, Wygrecka M, Kwapiszewska G. Between inflammation and thrombosis: endothelial cells in COVID-19. Eur Respir J, 2021, 58(3):2100377. https:\/\/doi.org\/10.1183\/13993003.00377-2021","DOI":"10.1183\/13993003.00377-2021"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"[9] Zhang H, Zhang H. Entry, egress and vertical transmission of SARS-CoV-2. J Mol Cell Biol, 2021, 13(3):168-174. https:\/\/doi.org\/10.1093\/jmcb\/mjab013","DOI":"10.1093\/jmcb\/mjab013"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"[10] Altunta\u015f \u015eL, G\u00fcne\u015f A, Kaplan AA, Ay\u015fit N, Keskin \u0130. Unravelling the impact of COVID-19 on pregnancy: in aspect of placental histopathology and umbilical cord macrophage immunoactivity with neonatal outcomes. J Reprod Immunol, 2024, 162:104207. https:\/\/doi.org\/10.1016\/j.jri.2024.104207","DOI":"10.1016\/j.jri.2024.104207"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"[11] Semmes EC, Coyne CB. Innate immune defenses at the maternal-fetal interface. Curr Opin Immunol, 2022, 74:60-67. https:\/\/doi.org\/10.1016\/j.coi.2021.10.007","DOI":"10.1016\/j.coi.2021.10.007"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"[12] Facchetti F, Bugatti M, Drera E, Tripodo C, Sartori E, Cancila V, Papaccio M, Castellani R, Casola S, Boniotti MB, Cavadini P, Lavazza A. SARS-CoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecular analyses of placenta. EBioMedicine, 2020, 59:102951. https:\/\/doi.org\/10.1016\/j.ebiom.2020.102951","DOI":"10.1016\/j.ebiom.2020.102951"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"[13] Liu HY, Guo J, Zeng C, Cao Y, Ran R, Wu T, Yang G, Zhao D, Yang P, Yu X, Zhang W, Liu SM, Zhang Y. Transient early fine motor abnormalities in infants born to COVID-19 mothers are associated with placental hypoxia and ischemia. Front Pediatr, 2022, 9:793561. https:\/\/doi.org\/10.3389\/fped.2021.793561","DOI":"10.3389\/fped.2021.793561"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"[14] Litman EA, Yin Y, Nelson SJ, Capbarat E, Kerchner D, Ahmadzia HK. Adverse perinatal outcomes in a large United States birth cohort during the COVID-19 pandemic. 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Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: a sequential, prospective meta-analysis. Am J Obstet Gynecol, 2023, 228(2):161-177. https:\/\/doi.org\/10.1016\/j.ajog.2022.08.038","DOI":"10.1016\/j.ajog.2022.08.038"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"[16] Covali R, Socolov D, Socolov R, Pavaleanu I, Carauleanu A, Akad M, Boiculese VL, Adam AM. Complete blood count peculiarities in pregnant SARS-CoV-2-infected patients at term: a cohort study. Diagnostics (Basel), 2021, 12(1):80. https:\/\/doi.org\/10.3390\/diagnostics12010080","DOI":"10.3390\/diagnostics12010080"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"[17] K\u0131l\u0131c J, Ebik B, Bacaks\u0131z F, Ekin N, Kal\u0131n BS. Is lymphopenia a predictor of mortality in patients with COVID-19? Acta Clin Croat, 2023, 62(1):82-87. https:\/\/doi.org\/10.20471\/acc.2023.62.01.10","DOI":"10.20471\/acc.2023.62.01.10"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"[18] Malik P, Patel U, Mehta D, Patel N, Kelkar R, Akrmah M, Gabrilove JL, Sacks H. Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis. BMJ Evid Based Med, 2021, 26(3):107-108. https:\/\/doi.org\/10.1136\/bmjebm-2020-111536","DOI":"10.1136\/bmjebm-2020-111536"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"[19] Mazzoni A, Salvati L, Maggi L, Capone M, Vanni A, Spinicci M, Mencarini J, Caporale R, Peruzzi B, Antonelli A, Trotta M, Zammarchi L, Ciani L, Gori L, Lazzeri C, Matucci A, Vultaggio A, Rossi O, Almerigogna F, Parronchi P, Fontanari P, Lavorini F, Peris A, Rossolini GM, Bartoloni A, Romagnani S, Liotta F, Annunziato F, Cosmi L. Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent. J Clin Invest, 2020, 130(9):4694-4703. https:\/\/doi.org\/10.1172\/JCI138554","DOI":"10.1172\/JCI138554"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"[20] Heming M, Li X, R\u00e4uber S, Mausberg AK, B\u00f6rsch AL, Hartlehnert M, Singhal A, Lu IN, Fleischer M, Szepanowski F, Witzke O, Brenner T, Dittmer U, Yosef N, Kleinschnitz C, Wiendl H, Stettner M, Meyer Zu H\u00f6rste G. Neurological manifestations of COVID-19 feature T cell exhaustion and dedifferentiated monocytes in cerebrospinal fluid. Immunity, 2021, 54(1):164-175.e6. https:\/\/doi.org\/10.1016\/j.immuni.2020.12.011","DOI":"10.1016\/j.immuni.2020.12.011"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"[21] Diao B, Wang C, Tan Y, Chen X, Liu Y, Ning L, Chen L, Li M, Liu Y, Wang G, Yuan Z, Feng Z, Zhang Y, Wu Y, Chen Y. Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19). Front Immunol, 2020, 11:827. https:\/\/doi.org\/10.3389\/fimmu.2020.00827","DOI":"10.3389\/fimmu.2020.00827"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"[22] Roe K. A role for T-cell exhaustion in long COVID-19 and severe outcomes for several categories of COVID-19 patients. J Neurosci Res, 2021, 99(10):2367-2376. https:\/\/doi.org\/10.1002\/jnr.24917","DOI":"10.1002\/jnr.24917"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"[23] Toori KU, Qureshi MA, Chaudhry A. Lymphopenia: a useful predictor of COVID-19 disease severity and mortality. Pak J Med Sci, 2021, 37(7):1984-1988. https:\/\/doi.org\/10.12669\/pjms.37.7.4085","DOI":"10.12669\/pjms.37.7.4085"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"[24] Chi J, Gong W, Gao Q. Clinical characteristics and outcomes of pregnant women with COVID-19 and the risk of vertical transmission: a systematic review. Arch Gynecol Obstet, 2021, 303(2):337-345. https:\/\/doi.org\/10.1007\/s00404-020-05889-5","DOI":"10.1007\/s00404-020-05889-5"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"[25] Shi L, Wang Y, Yang H, Duan G, Wang Y. Laboratory abnormalities in pregnant women with novel coronavirus disease 2019. Am J Perinatol, 2020, 37(10):1070-1073. https:\/\/doi.org\/10.1055\/s-0040-1712181","DOI":"10.1055\/s-0040-1712181"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"[26] Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Li J, Zhao D, Xu D, Gong Q, Liao J, Yang H, Hou W, Zhang Y. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet, 2020, 395(10226):809-815. https:\/\/doi.org\/10.1016\/S0140-6736(20)30360-3","DOI":"10.1016\/S0140-6736(20)30360-3"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"[27] Schoenmakers S, Snijder P, Verdijk RM, Kuiken T, Kamphuis SSM, Koopman LP, Krasemann TB, Rousian M, Broekhuizen M, Steegers EAP, Koopmans MPG, Fraaij PLA, Reiss IKM. Severe acute respiratory syndrome coronavirus 2 placental infection and inflammation leading to fetal distress and neonatal multi-organ failure in an asymptomatic woman. J Pediatric Infect Dis Soc, 2021, 10(5):556-561. https:\/\/doi.org\/10.1093\/jpids\/piaa153","DOI":"10.1093\/jpids\/piaa153"},{"key":"ref27","unstructured":"[28] Galesanu C, Buzduga C, Florescu A, Moisii L, Ciubotaru V. Diabetes mellitus, chronic complication in patients with acromegaly: case report and review of the literature. Rev Med Chir Soc Med Nat Iasi, 2015, 119(1):92-96."},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"[29] Savin ML, Mihai F, Gheorghe L, Lupascu Ursulescu C, Negru D, Trofin AM, Zabara M, Nutu V, Cadar R, Blaj M, Lovin O, Crumpei F, Lupascu C. Proposal of a preoperative CT-based score to predict the risk of clinically relevant pancreatic fistula after cephalic pancreatoduodenectomy. Medicina (Kaunas), 2021, 57(7):650. https:\/\/doi.org\/10.3390\/medicina57070650","DOI":"10.3390\/medicina57070650"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"[30] Costan VV, Ciocan-Pendefunda CC, Ciofu ML, Boisteanu O, Timofte DV, Gheorghe L, Bogdanici C, Preda C. Balancing orbital volume reduction and redistribution for a tailored surgical treatment in Graves' ophthalmopathy. Graefes Arch Clin Exp Ophthalmol, 2020, 258(10):2313-2320. https:\/\/doi.org\/10.1007\/s00417-020-04807-4","DOI":"10.1007\/s00417-020-04807-4"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"[31] Tanasa IA, Manciuc C, Carauleanu A, Navolan DB, Bohiltea RE, Nemescu D. Anosmia and ageusia associated with coronavirus infection (COVID-19) - what is known? Exp Ther Med, 2020, 20(3):2344-2347. https:\/\/doi.org\/10.3892\/etm.2020.8808","DOI":"10.3892\/etm.2020.8808"},{"key":"ref31","unstructured":"[32] Berceanu C, Mehedin\u0163u C, Berceanu S, Voicu NL, Br\u0103til\u0103 E, Istrate-Ofi\u0163eru AM, Navolan DB, Niculescu M, Szasz FA, C\u0103pit\u0103nescu RG, V\u0103duva CC. Morphological and ultrasound findings in multiple pregnancy placentation. Rom J Morphol Embryol, 2018, 59(2):435-453."},{"key":"ref32","unstructured":"[33] Albu DF, Albu CC, V\u0103duva CC, Niculescu M, Edu A. Diagnosis problems in a case of ovarian tumor - case presentation. Rom J Morphol Embryol, 2016, 57(4):1437-1442"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"[34] Melinte-Popescu AS, Popa RF, Harabor V, Nechita A, Harabor AM, Adam AM, Vasilache IA, Melinte-Popescu M, Vaduva C, Socolov D. Managing fetal ovarian cysts: clinical experience with a rare disorder. Medicina (Kaunas), 2023, 59(4):715. https:\/\/doi.org\/10.3390\/medicina59040715","DOI":"10.3390\/medicina59040715"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"[35] Covali R, Socolov D, Pavaleanu I, Carauleanu A, Boiculese VL, Socolov R. SARS-CoV-2 infection susceptibility of pregnant patients at term regarding ABO and Rh blood groups: a cohort study. 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