{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T05:24:58Z","timestamp":1740720298606,"version":"3.38.0"},"reference-count":37,"publisher":"Societatea Romana de Morfologie","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2025,2,20]]},"abstract":"<jats:p>Castleman disease (CD) is a group of lymphoproliferative disorders characterized by abnormal enlargement of lymph nodes (LNs) and a wide range of symptoms. Only a few cases are found in the head and neck. Based on clinical presentation and evolution, the disease can be classified into two main subtypes: unicentric CD (UCD), characterized by the enlargement of a single LN or a single LN chain, and multicentric CD (MCD), characterized by the involvement of multiple LNs and regions, with more important systemic symptoms and a poor prognosis. CD is also known as \u201cthe great mimicker\u201d and can be easily misdiagnosed, sharing similar clinical and imaging characteristics with other pathologies, mainly when it is found in the neck. A histopathological (HP) and immunohistochemical (IHC) correlation is essential in these cases to accurately diagnose and establish the proper treatment plan. In light of this, we present a rare case of a 15-year-old young female with a slowly expanding, isolated supraclavicular mass. An excisional biopsy was performed, and the results confirmed the presence of CD, hyaline-vascular type. As of this writing, there was no evidence of recurrence or new enlarged LNs. We also review CD\u2019s clinical and HP features and the diagnostic and treatment challenges it poses.<\/jats:p>","DOI":"10.47162\/rjme.65.4.03","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T10:37:15Z","timestamp":1740652635000},"page":"575-581","source":"Crossref","is-referenced-by-count":0,"title":["Castleman disease as the great mimicker: the role of complex morpho-pathological evaluation"],"prefix":"10.47162","volume":"65","author":[{"name":"Department of Otorhinolaryngology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Department of Otorhinolaryngology, Sf. Maria Hospital, Bucharest, Romania","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ionu\u0163","family":"T\u0103nase","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caius-Codru\u0163","family":"Sarafoleanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otorhinolaryngology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Department of Otorhinolaryngology, Sf. Maria Hospital, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan Mihail","family":"Cobzeanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otorhinolaryngology, Grigore T. Popa University of Medicine and Pharmacy, Ia\u015fi, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina-Maria","family":"Georgescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PhD Student, University of Medicine and Pharmacy of Craiova, Romania; Department of Laboratory Medicine, Victor Babe\u015f Clinical Hospital of Infectious Diseases and Pneumophthisiology, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin-Ioan","family":"Busuioc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pathology, Sf. Maria Hospital, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Iov\u0103nescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PhD Student, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Department of Otorhinolaryngology, Emergency Municipal Hospital, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentina-Carmen","family":"Badea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otorhinolaryngology, Medicover Hospital, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26736","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Castleman B, Iverson L, Menendez VP. 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Arch Pathol Lab Med, 2024, 148(1):99-106. https:\/\/doi.org\/10.5858\/arpa.2022-0404-RA\"","DOI":"10.5858\/arpa.2022-0404-RA"}],"container-title":["Romanian Journal of Morphology and Embryology"],"original-title":[],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T10:47:11Z","timestamp":1740653231000},"score":1,"resource":{"primary":{"URL":"https:\/\/rjme.ro\/archive\/65\/4\/3\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,2,13]]},"published-print":{"date-parts":[[2025,2,20]]}},"URL":"https:\/\/doi.org\/10.47162\/rjme.65.4.03","relation":{},"ISSN":["1220-0522","2066-8279"],"issn-type":[{"value":"1220-0522","type":"print"},{"value":"2066-8279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]}}}