{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T05:24:54Z","timestamp":1740720294038,"version":"3.38.0"},"reference-count":22,"publisher":"Societatea Romana de Morfologie","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2025,2,20]]},"abstract":"<jats:p>Adenocarcinoma (ADK) of the ileum is an infrequent cancer that poses significant diagnostic and treatment difficulties. This article analyses the existing case literature to investigate the correlation between pyloric gland metaplasia (PGM) and the onset of ileal ADK. PGM, defined by the atypical transformation of intestinal epithelial cells into gastric-type mucosa, has been recognized as a possible precursor lesion in the spectrum of several gastrointestinal malignancies. We intend to clarify the clinical characteristics, histological results, and outcomes linked to ileal ADK originating from PGM through an exhaustive examination of recorded cases. Our findings indicate that early identification of metaplastic alterations may be essential for enhancing prognosis and informing therapeutic choices. This study emphasizes the need for additional research to elucidate the mechanisms driving this transition and to improve diagnostic precision in clinical practice.<\/jats:p>","DOI":"10.47162\/rjme.65.4.05","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T10:37:15Z","timestamp":1740652635000},"page":"593-598","source":"Crossref","is-referenced-by-count":0,"title":["Adenocarcinoma of the ileum: literature insights on pyloric gland metaplasia"],"prefix":"10.47162","volume":"65","author":[{"name":"Second Department of Surgery, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Stancu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u0103zvan Alexandru","family":"Ciocan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Surgery\u2013Practical Abilities, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius George","family":"Teodorescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Morphological Sciences, Emergency County Clinical Hospital, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doini\u0163a","family":"Cri\u015fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Morphological Sciences, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florin Vasile","family":"Mih\u0103ileanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Second Department of Surgery, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015etefan","family":"Ursu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Surgery\u2013Practical Abilities, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liviu","family":"Tartacovschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Second Department of General Surgery, Emergency County Clinical Hospital, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015etefan Lucian","family":"Popa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Second Department of Internal Medicine, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Diana","family":"Gherman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Surgery\u2013Practical Abilities, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26736","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Aparicio T, Zaanan A, Svrcek M, Laurent-Puig P, Carrere N, Manfredi S, Locher C, Afchain P. Small bowel adenocarcinoma: epidemiology, risk factors, diagnosis and treatment. Dig Liver Dis, 2014, 46(2):97-104. https:\/\/doi.org\/10.1016\/j.dld.2013.04.013","DOI":"10.1016\/j.dld.2013.04.013"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"[2] Whitcomb E, Xiu L, Xiao SY. Crohn enteritis-associated small bowel adenocarcinomas exhibit gastric differentiation. Hum Pathol, 2014, 45(2):359-367. https:\/\/doi.org\/10.1016\/j.humpath.2013.09.014","DOI":"10.1016\/j.humpath.2013.09.014"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"[3] Dabaja BS, Suki D, Pro B, Bonnen M, Ajani J. Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcome of 217 patients. Cancer, 2004, 101(3):518-526. https:\/\/doi.org\/10.1002\/cncr.20404","DOI":"10.1002\/cncr.20404"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"[4] Lepage C, Bouvier AM, Manfredi S, Dancourt V, Faivre J. Incidence and management of primary malignant small bowel cancers: a well-defined French population study. Am J Gastroenterol, 2006, 101(12):2826-2832. https:\/\/doi.org\/10.1111\/j.1572-0241.2006.00854.x","DOI":"10.1111\/j.1572-0241.2006.00854.x"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"[5] Rasch S, Alg\u00fcl H. A clinical perspective on the role of chronic inflammation in gastrointestinal cancer. Clin Exp Gastroenterol, 2014, 7:261-272. https:\/\/doi.org\/10.2147\/CEG.S43457","DOI":"10.2147\/CEG.S43457"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"[6] Tsubone M, Kozuka S, Taki T, Hoshino M, Yasui A, Hachisuka K. Heterotopic gastric mucosa in the small intestine. Acta Pathol Jpn, 1984, 34(6):1425-1431. https:\/\/doi.org\/10.1111\/j.1440-1827.1984.tb00566.x","DOI":"10.1111\/j.1440-1827.1984.tb00566.x"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"[7] Franzin G, Musola R, Zamboni G, Manfrini C. Gastritis cystica polyposa: a possible precancerous lesion. Tumori, 1985, 71(1):13-18. https:\/\/doi.org\/10.1177\/030089168507100102","DOI":"10.1177\/030089168507100102"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"[8] Okumura Y, Miyazaki S, Fujitani K, Fushimi H, Danno K, Matsuda C. [A case report of adenocarcinoma in a Meckel's diverticulum arising from ectopic gastric mucosa]. Nihon Rinsho Geka Gakkai Zasshi (J Jpn Surg Assoc), 2015, 76(9):2231-2236. https:\/\/doi.org\/10.3919\/jjsa.76.2231","DOI":"10.3919\/jjsa.76.2231"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"[9] Caruso ML, Marzullo F. Jejunal adenocarcinoma in congenital heterotopic gastric mucosa. J Clin Gastroenterol, 1988, 10(1):92-94. https:\/\/doi.org\/10.1097\/00004836-198802000-00020","DOI":"10.1097\/00004836-198802000-00020"},{"issue":"3","key":"ref9","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/0016-5085(81)90601-6","article-title":"The histologic appearance of dysplasia (precarcinomatous change) in Crohn's disease of the small and large intestine","volume":"81","author":"Simpson","year":"1981","unstructured":"[10] Simpson S, Traube J, Riddell RH. The histologic appearance of dysplasia (precarcinomatous change) in Crohn's disease of the small and large intestine. Gastroenterology, 1981, 81(3):492-501.","journal-title":"Gastroenterology"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"[11] Schaefer IM, Sch\u00fcler P, Enders C, Scharf JG, Cameron S, Ramadori G, F\u00fczesi L. High chromosomal instability in adenocarcinoma of the ileum arising from multifocal gastric heterotopia with gastritis cystica profunda. Med Oncol, 2011, 28(4):1023-1026. https:\/\/doi.org\/10.1007\/s12032-010-9604-2","DOI":"10.1007\/s12032-010-9604-2"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"[12] Planck M, Ericson K, Piotrowska Z, Halvarsson B, Rambech E, Nilbert M. Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine. Cancer, 2003, 97(6):1551-1557. https:\/\/doi.org\/10.1002\/cncr.11197","DOI":"10.1002\/cncr.11197"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"[13] Chan OTM, Chen ZME, Chung F, Kawachi K, Phan DC, Himmelfarb E, Lin F, Perry A, Wang HL. Lack of HER2 overexpression and amplification in small intestinal adenocarcinoma. Am J Clin Pathol, 2010, 134(6):880-885. https:\/\/doi.org\/10.1309\/AJCPK6QHNNOEMJIM","DOI":"10.1309\/AJCPK6QHNNOEMJIM"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"[14] Miwa Y, Sato Y, Hirano K, Sunami E, Takahashi M, Kosugi SI, Suda T, Hasegawa G. An adenocarcinoma in an inverted Meckel's diverticulum with intussusception. Surg Case Rep, 2023, 9(1):95. https:\/\/doi.org\/10.1186\/s40792-023-01680-1","DOI":"10.1186\/s40792-023-01680-1"},{"key":"ref14","unstructured":"[15] Kusumoto H, Yoshitake H, Mochida K, Kumashiro R, Sano C, Inutsuka S. Adenocarcinoma in Meckel's diverticulum: report of a case and review of 30 cases in the English and Japanese literature. Am J Gastroenterol, 1992, 87(7):910-913."},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"[16] Aparicio T, Svrcek M, Zaanan A, Beohou E, Laforest A, Afchain P, Mitry E, Taieb J, Di Fiore F, Gornet JM, Thirot-Bidault A, Sobhani I, Malka D, Lecomte T, Locher C, Bonnetain F, Laurent-Puig P. Small bowel adenocarcinoma phenotyping, a clinicobiological prognostic study. Br J Cancer, 2013, 109(12):3057-3066. https:\/\/doi.org\/10.1038\/bjc.2013.677","DOI":"10.1038\/bjc.2013.677"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"[17] Laforest A, Aparicio T, Zaanan A, Silva FP, Didelot A, Desbeaux A, Le Corre D, Benhaim L, Pallier K, Aust D, Pistorius S, Blons H, Svrcek M, Laurent-Puig P. ERBB2 gene as a potential therapeutic target in small bowel adenocarcinoma. Eur J Cancer, 2014, 50(10):1740-1746. https:\/\/doi.org\/10.1016\/j.ejca.2014.04.007","DOI":"10.1016\/j.ejca.2014.04.007"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"[18] Nussbaum DP, Bhattacharya SD, Jiang X, Cardona DM, Strickler JH, Blazer DG 3rd. Gastroesophageal heterotopia and HER2\/neu overexpression in an adenocarcinoma arising from a small bowel duplication. Arch Pathol Lab Med, 2014, 138(3):428-431. https:\/\/doi.org\/10.5858\/arpa.2012-0523-CR","DOI":"10.5858\/arpa.2012-0523-CR"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"[19] Frank BB. The road to heterotopia and metaplasia. Gastrointest Endosc, 1983, 29(2):137-138. https:\/\/doi.org\/10.1016\/s0016-5107(83)72555-1","DOI":"10.1016\/S0016-5107(83)72555-1"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"[20] Zheng Y, Wu L, Hu Z, Liao H, Li X. Role of the Forkhead box family protein FOXF2 in the progression of solid tumor: systematic review. J Cancer Res Clin Oncol, 2024, 151(1):14. https:\/\/doi.org\/10.1007\/s00432-024-06047-z","DOI":"10.1007\/s00432-024-06047-z"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"[21] Stancu MI, Giubelan A, Mitroi G, Istrate-Ofi\u0163eru AM, Popescu G, Hon\u0163aru SO, Badea-Voiculescu O, P\u00eer\u015fcoveanu DFV, Mogoant\u0103 S\u015e, Mogoant\u0103 L. Assessment of tumor microenvironment in gastric adenocarcinoma. Rom J Morphol Embryol, 2023, 64(2):251-261. https:\/\/doi.org\/10.47162\/RJME.64.2.16","DOI":"10.47162\/RJME.64.2.16"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"[22] Giubelan A, Stancu MI, Hon\u0163aru SO, M\u0103l\u0103escu GD, Badea-Voiculescu O, Firoiu C, Mogoant\u0103 S\u015e. Tumor angiogenesis in gastric cancer. Rom J Morphol Embryol, 2023, 64(3):311-318. https:\/\/doi.org\/10.47162\/RJME.64.3.03\"","DOI":"10.47162\/RJME.64.3.03"}],"container-title":["Romanian Journal of Morphology and Embryology"],"original-title":[],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T10:47:39Z","timestamp":1740653259000},"score":1,"resource":{"primary":{"URL":"https:\/\/rjme.ro\/archive\/65\/4\/5\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,2,13]]},"published-print":{"date-parts":[[2025,2,20]]}},"URL":"https:\/\/doi.org\/10.47162\/rjme.65.4.05","relation":{},"ISSN":["1220-0522","2066-8279"],"issn-type":[{"value":"1220-0522","type":"print"},{"value":"2066-8279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]}}}