{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:14:50Z","timestamp":1789578890867,"version":"build-2803163510"},"reference-count":35,"publisher":"Societatea Romana de Morfologie","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2025,2,20]]},"abstract":"<jats:p>Nasal polyps develop as a result of inflammation of the nasal and sinus mucosa. Allergies and nasal infections cause inflammation, and these are the main reasons why these symptoms appear in the first place. This study highlights the involvement of macrophages, as well as T- and B-lymphocytes, in the pathophysiology of nasal polyps. For the evaluation of lymphocyte activity, we analyzed the immunoexpression of cluster of differentiation 45RO [CD45RO; common leukocyte antigen (CLA)] and for macrophages we analyzed the immunoexpression of cluster of differentiation 68 (CD68). Our research, conducted on 110 sinonasal polyps harvested from chronic rhinosinusitis patients with nasal polyps, focused on analyzing both the epithelial and stromal compartments in relation to pre-established composite scores. Additionally, specific histopathological parameters were included in the study. We concluded that the inflammatory cells were more prevalent in the stromal compartment compared to the epithelial compartment. The statistical evaluation of CD45RO (CLA) and CD68 scores in the stromal compartment were also associated with high histological composite scores.<\/jats:p>","DOI":"10.47162\/rjme.65.4.12","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T10:37:15Z","timestamp":1740652635000},"page":"655-660","source":"Crossref","is-referenced-by-count":1,"title":["Histopathological parameters and immunoexpression of CD45RO (CLA) and CD68 in chronic rhinosinusitis with nasal polyps"],"prefix":"10.47162","volume":"65","author":[{"name":"Department of Anatomy and Embryology, University of Medicine and Pharmacy of Craiova, Romania; Department of Otorhinolaryngology, Emergency County Clinical Hospital, Craiova, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Enache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Emilian","family":"Stepan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania; Department of Pathology, Emergency County Clinical Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin","family":"Anghelina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Otorhinolaryngology, Emergency County Clinical Hospital, Craiova, Romania; Department of Otorhinolaryngology, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionic\u0103 Daniel","family":"V\u00eelcea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of General Surgery, University of Medicine and Pharmacy of Craiova, Romania; IInd General Surgery Department, Emergency County Clinical Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mioara Desdemona","family":"Stepan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Infant Care, Pediatrics and Neonatology, University of Medicine and Pharmacy of Craiova, Romania; Ist Pediatrics Department, Emergency County Clinical Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Aurelia","family":"Mogoant\u0103","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Otorhinolaryngology, Emergency County Clinical Hospital, Craiova, Romania; Department of Otorhinolaryngology, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Anatomy and Embryology, University of Medicine and Pharmacy of Craiova, Romania; Department of Otorhinolaryngology, Emergency County Clinical Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26736","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Stevens WW, Schleimer RP, Kern RC. 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