{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:17:07Z","timestamp":1784161027005,"version":"3.55.0"},"reference-count":16,"publisher":"Societatea Romana de Morfologie","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2025,5,23]]},"abstract":"<jats:p>Walthard cell nest (WCN) is a rare incidental finding in the intestine including the vermiform appendix and the mesocolon. This article describes a case of WNCs in the vermiform appendix and the mesocolon. The location in the mesocolon is reported for the first time. A review of the seven published intestinal cases including our report is presented. The lesion is seen in children, adults, and both sexes. The number of present cell nests varied between one and three per case. The diagnosis rests on histopathological examination. A potential source for histopathological diagnostic error includes a NET. The coexistence of WCNs with an appendicular neuroendocrine tumor (NET) may complicate the diagnosis. WCNs show the immunohistochemical profile of urothelial differentiation. To establish a diagnosis of WCN the absence of significant atypia, significant mitotic activity, atypical mitoses, necrosis, desmoplastic stroma, and tissue invasion must be confirmed. The lesion is a benign proliferation and once the appendectomy or colectomy has been performed, no further treatment is required.<\/jats:p>","DOI":"10.47162\/rjme.66.1.24","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T08:40:16Z","timestamp":1748594416000},"page":"251-255","source":"Crossref","is-referenced-by-count":2,"title":["Incidental Walthard cell nests in the intestine. Report of two cases and review of the literature"],"prefix":"10.47162","volume":"66","author":[{"name":"Pathology Unit, Department of Medical and Surgical Sciences, University of Cantabria\u2013IDIVAL, Santander, Spain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Fernando","family":"Val-Bernal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta-Mar\u00eda","family":"Mayorga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Service of Anatomical Pathology, Marqu\u00e9s de Valdecilla University Hospital\u2013IDIVAL, Santander, Spain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Requena-Cabello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Service of Anatomical Pathology, Marqu\u00e9s de Valdecilla University Hospital\u2013IDIVAL, Santander, Spain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramiro-Raphael","family":"Gutierrez-Vasquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Service of General and Digestive Surgery, Marqu\u00e9s de Valdecilla University Hospital\u2013IDIVAL, Santander, Spain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Del Carmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Service of Anatomical Pathology, Marqu\u00e9s de Valdecilla University Hospital\u2013IDIVAL, Santander, Spain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Garc\u00eda-Cardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Service of General and Digestive Surgery, Marqu\u00e9s de Valdecilla University Hospital\u2013IDIVAL, Santander, Spain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26736","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Teoh TB. The structure and development of Walthard nests. J Pathol Bacteriol, 1953, 66(2):433-439. https:\/\/doi.org\/10.1002\/path.1700660214","DOI":"10.1002\/path.1700660214"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"[2] Gorter RR, van Amstel P, van der Lee JH, van der Voorn P, Bakx R, Heij HA. Unexpected findings after surgery for suspected appendicitis rarely change treatment in pediatric patients; results from a cohort study. J Pediatr Surg, 2017, 52(8):1269-1272. https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.02.012","DOI":"10.1016\/j.jpedsurg.2017.02.012"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"[3] Squires L, Matsika A, Allan C, Srinivasan B. Incidental urothelial rests within a vermiform appendix. Pathology, 2018, 50(Suppl 1):S144. https:\/\/doi.org\/10.1016\/J.pathol.2017.11.063","DOI":"10.1016\/j.pathol.2017.11.063"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"[4] Schild MH, Leckey BD, Coulas A, McCall S. Incidental urothelial rest within the vermiform appendix of a paediatric male patient: an extremely rare entity. BMJ Case Rep, 2020, 13(1):e233530. https:\/\/doi.org\/10.1136\/bcr-2019-233530","DOI":"10.1136\/bcr-2019-233530"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"[5] Punjabi LS, Hong RGC. Incidental urothelial rests in the vermiform appendix: a case report in an adult male with appendicitis and appendiceal neuroendocrine tumor. Hum Pathol Case Rep, 2021, 24:200515. https:\/\/doi.org\/10.1016\/j.ehpc.2021.200515","DOI":"10.1016\/j.ehpc.2021.200515"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"[6] Chang E, Park K, Essaak MA, Veenstra M, Shehata BM. Urothelial rests, incidental finding in a patient with acute appendicitis: a case report and literature review. 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The borderland of embryology and pathology. 2nd edition, Butterworth & Co. Ltd., London, UK, 1962, 519-583.\""}],"container-title":["Romanian Journal of Morphology and Embryology"],"original-title":[],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T08:51:42Z","timestamp":1748595102000},"score":1,"resource":{"primary":{"URL":"https:\/\/rjme.ro\/archive\/66\/1\/24\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,5,15]]},"published-print":{"date-parts":[[2025,5,23]]}},"URL":"https:\/\/doi.org\/10.47162\/rjme.66.1.24","relation":{},"ISSN":["1220-0522","2066-8279"],"issn-type":[{"value":"1220-0522","type":"print"},{"value":"2066-8279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]}}}