{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T23:07:48Z","timestamp":1768864068090,"version":"3.49.0"},"reference-count":59,"publisher":"Societatea Romana de Morfologie","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2025,12,12]]},"abstract":"<jats:p>Metastatic involvement of the oral and maxillofacial region is an uncommon clinical event. These secondary lesions may develop in several anatomical locations, most frequently within the parotid glands or orbital structures. While many primary tumors that spread to these regions arise from neighboring sites such as the scalp, face, oral cavity, or pharynx, distant subclavicular malignancies can also give rise to metastases in these areas. Among such tumors, renal cell carcinoma (RCC) is the third most frequent source of metastasis to the oral and maxillofacial region. Nevertheless, reports of RCC spreading to the parotid or orbital regions remain exceptionally rare. We present a distinctive clinical case of a 54-year-old man with clear cell RCC that, during its progression, produced simultaneous metastases to both parotid glands and to the orbital region \u2013 a combination that, to our knowledge, has not been previously documented in the medical literature.<\/jats:p>","DOI":"10.47162\/rjme.66.3.19","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:41:45Z","timestamp":1768819305000},"page":"601-609","source":"Crossref","is-referenced-by-count":0,"title":["Renal clear cell carcinoma with bilateral parotid and orbital metastases \u2013 case report"],"prefix":"10.47162","volume":"66","author":[{"name":"Department of Oral and Maxillofacial Surgery, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius Octavian","family":"Pricop","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hora\u0163iu Constantin","family":"Urechescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Oral and Maxillofacial Surgery, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Zar\u0103","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Microscopic Morphology, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Angiogenesis Research Center, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Service of Pathology, Emergency City Hospital,","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Camen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Oral and Maxillofacial Surgery, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eerban","family":"Talpo\u015f-Niculescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Oral and Maxillofacial Surgery, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana","family":"Cuzic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Prosthodontics, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisia","family":"Pricop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Doctoral School \u2013 Dental Medicine, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca Maria","family":"Clo\u015fca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Microscopic Morphology, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Angiogenesis Research Center, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Service of Pathology, Emergency City Hospital,","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26736","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Hirshberg A, Berger R, Allon I, Kaplan I. Metastatic tumors to the jaws and mouth. Head Neck Pathol, 2014, 8(4):463-474. https:\/\/doi.org\/10.1007\/s12105-014-0591-z","DOI":"10.1007\/s12105-014-0591-z"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"[2] Hanahan D. Hallmarks of cancer: new dimensions. Cancer Discov, 2022, 12(1):31-46. https:\/\/doi.org\/10.1158\/2159-8290.CD-21-1059","DOI":"10.1158\/2159-8290.CD-21-1059"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"[3] Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity - pathogenesis and analysis of 673 cases. Oral Oncol, 2008, 44(8):743-752. https:\/\/doi.org\/10.1016\/j.oraloncology.2007.09.012","DOI":"10.1016\/j.oraloncology.2007.09.012"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"[4] Kirschnick LB, Schuch LF, Cademartori MG, Vasconcelos ACU. Metastasis to the oral and maxillofacial region: a systematic review. Oral Dis, 2022, 28(1):23-32. https:\/\/doi.org\/10.1111\/odi.13611","DOI":"10.1111\/odi.13611"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"[5] Clausen F, Poulsen H. Metastatic carcinoma of the jaws. Acta Pathol Microbiol Scand, 1963, 57:361-374. https:\/\/doi.org\/10.1111\/j.1699-0463.1963.tb05105.x","DOI":"10.1111\/j.1699-0463.1963.tb05105.x"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"[6] Ho DP, Wilkinson PE, Vogel RI, Gopalakrishnan R, Argyris PP. Metastatic tumors to the oral soft tissues and jawbones: a retrospective analysis of 40 cases and review of the literature. Head Neck Pathol, 2022, 16(3):802-813. https:\/\/doi.org\/10.1007\/s12105-022-01451-8","DOI":"10.1007\/s12105-022-01451-8"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"[7] Maschino F, Guillet J, Curien R, Dolivet G, Bravetti P. Oral metastasis: a report of 23 cases. Int J Oral Maxillofac Surg, 2013, 42(2):164-168. https:\/\/doi.org\/10.1016\/j.ijom.2012.10.029","DOI":"10.1016\/j.ijom.2012.10.029"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"[8] Hirshberg A, Leibovich P, Buchner A. Metastases to the oral mucosa: analysis of 157 cases. J Oral Pathol Med, 1993, 22(9):385-390. https:\/\/doi.org\/10.1111\/j.1600-0714.1993.tb00128.x","DOI":"10.1111\/j.1600-0714.1993.tb00128.x"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"[9] Franzen AM, G\u00fcnzel T, Lieder A. Parotid gland metastases of distant primary tumours: a diagnostic challenge. Auris Nasus Larynx, 2016, 43(2):187-191. https:\/\/doi.org\/10.1016\/j.anl.2015.09.010","DOI":"10.1016\/j.anl.2015.09.010"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"[10] Yeung KW, Chiang PT, Chang CY, Yuan BC. A parotid gland mass as an initial metastatic manifestation of nasopharyngeal carcinoma. J Cancer Res Pract, 2018, 5(3):123-126. https:\/\/doi.org\/10.1016\/j.jcrpr.2018.03.004","DOI":"10.1016\/j.jcrpr.2018.03.004"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"[11] Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery Lecture, part 1. Ophthalmology, 2004, 111(5):997-1008. https:\/\/doi.org\/10.1016\/j.ophtha.2003.01.002","DOI":"10.1016\/j.ophtha.2003.01.002"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"[12] Bonavolont\u00e0 G, Strianese D, Grassi P, Comune C, Tranfa F, Uccello G, Iuliano A. An analysis of 2,480 space-occupying lesions of the orbit from 1976 to 2011. Ophthalmic Plast Reconstr Surg, 2013, 29(2):79-86. https:\/\/doi.org\/10.1097\/IOP.0b013e31827a7622","DOI":"10.1097\/IOP.0b013e31827a7622"},{"key":"ref12","unstructured":"[13] Magliozzi P, Strianese D, Bonavolont\u00e0 P, Ferrara M, Ruggiero P, Carandente R, Bonavolont\u00e0 G, Tranfa F. Orbital metastases in Italy. Int J Ophthalmol, 2015, 8(5):1018-1023. https:\/\/doi.org\/10.3980\/j.issn.2222-3959.2015.05.30"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"[14] Valenzuela AA, Archibald CW, Fleming B, Ong L, O'Donnell B, Crompton JJ, Selva D, McNab AA, Sullivan TJ. Orbital metastasis: clinical features, management and outcome. Orbit, 2009, 28(2-3):153-159. https:\/\/doi.org\/10.1080\/01676830902897470","DOI":"10.1080\/01676830902897470"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"[15] Eldesouky MA, Elbakary MA. Clinical and imaging characteristics of orbital metastatic lesions among Egyptian patients. Clin Ophthalmol, 2015, 9:1683-1687. https:\/\/doi.org\/10.2147\/OPTH.S87788","DOI":"10.2147\/OPTH.S87788"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"[16] Allen RC. Orbital metastases: when to suspect? when to biopsy? Middle East Afr J Ophthalmol, 2018, 25(2):60-64. https:\/\/doi.org\/10.4103\/meajo.MEAJO_93_18","DOI":"10.4103\/meajo.MEAJO_93_18"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"[17] Cai Z, Zhu C, Wang L, Zhu L, Zhang Z, Zhu H, Wang Y. A retrospective study of six patients with mandibular metastatic carcinoma. Oncol Lett, 2016, 11(6):3650-3654. https:\/\/doi.org\/10.3892\/ol.2016.4484","DOI":"10.3892\/ol.2016.4484"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"[18] Irani S. Metastasis to the jawbones: a review of 453 cases. J Int Soc Prev Community Dent, 2017, 7(2):71-81. https:\/\/doi.org\/10.4103\/jispcd.JISPCD_512_16","DOI":"10.4103\/jispcd.JISPCD_512_16"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"[19] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3):209-249. https:\/\/doi.org\/10.3322\/caac.21660","DOI":"10.3322\/caac.21660"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"[20] Kirschnick LB, Schuch LF, Gondak R, Rivero ERC, Gomes APN, Etges A, Tarquinio SBC, Mesquita RA, Caldeira PC, da Costa AAS, Mendon\u00e7a EF, Dos Santos JN, Smit C, Robinson L, Tager EMJR, Mosqueda-Taylor A, Pontes HAR, de Andrade BAB, Fonseca TC, Abrah\u00e3o AC, Agostini M, Roma\u00f1ach MJ, Alves FA, Jaguar GC, de Mendon\u00e7a NF, Pinto MBR, da Silva LC, Lopes MA, Vargas PA, van Heerden W, Abreu LG, Martins MD, Vasconcelos ACU. Clinicopathological features of metastasis to the oral and maxillofacial region - multicenter study. Head Neck Pathol, 2023, 17(4):910-920. https:\/\/doi.org\/10.1007\/s12105-023-01588-0","DOI":"10.1007\/s12105-023-01588-0"},{"key":"ref20","unstructured":"[21] World Cancer Research Fund (WCRF). WCRF International Statistics. WCRF, London, UK, 2025."},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"[22] Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin, 2022, 72(1):7-33. https:\/\/doi.org\/10.3322\/caac.21708","DOI":"10.3322\/caac.21708"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"[23] Patard JJ, Leray E, Rioux-Leclercq N, Cindolo L, Ficarra V, Zisman A, De La Taille A, Tostain J, Artibani W, Abbou CC, Lobel B, Guill\u00e9 F, Chopin DK, Mulders PF, Wood CG, Swanson DA, Figlin RA, Belldegrun AS, Pantuck AJ. Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. J Clin Oncol, 2005, 23(12):2763-2771. https:\/\/doi.org\/10.1200\/JCO.2005.07.055","DOI":"10.1200\/JCO.2005.07.055"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"[24] Choueiri TK, Motzer RJ. Systemic therapy for metastatic renal-cell carcinoma. N Engl J Med, 2017, 376(4):354-366. https:\/\/doi.org\/10.1056\/NEJMra1601333","DOI":"10.1056\/NEJMra1601333"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"[25] Shi JL, Zhou JQ, Li JP. Renal clear cell carcinoma with thyroid and parotid metastases: a case report. Oncol Lett, 2015, 10(4):2617-2619. https:\/\/doi.org\/10.3892\/ol.2015.3549","DOI":"10.3892\/ol.2015.3549"},{"key":"ref25","unstructured":"[26] Gnepp DR. Metastatic disease to major salivary glands. In: Ellis GL, Auclair PL, Gnepp DR (eds). Surgical pathology of the salivary glands. WB Saunders, Philadelphia, PA, USA, 1996, 421-425."},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"[27] Seifert G, Hennings K, Caselitz J. Metastatic tumors to the parotid and submandibular glands: analysis and differential diagnosis of 108 cases. Pathol Res Pract, 1986, 181(6):684-692. https:\/\/doi.org\/10.1016\/S0344-0338(86)80044-9","DOI":"10.1016\/S0344-0338(86)80044-9"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"[28] Closca RM, Nicoara A, Rakitovan M, Mot IC, Baderca F. Unpredictable metastasis in the head and neck region: a diagnostic immunohistochemical challenge. Diagnostics (Basel), 2023, 13(23):3513. https:\/\/doi.org\/10.3390\/diagnostics13233513","DOI":"10.3390\/diagnostics13233513"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"[29] Woods T, Fitzpatrick S, Cohen D, Islam M, Bhattacharyya I. Clear cell changes in salivary gland neoplasms: a 20-year retrospective study. Med Oral Patol Oral Cir Bucal, 2017, 22(3):e276-e281. https:\/\/doi.org\/10.4317\/medoral.21570","DOI":"10.4317\/medoral.21570"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"[30] Zhu S, Schuerch C, Hunt J. Review and update of immunohistochemistry in selected salivary gland and head and neck tumors. Arch Pathol Lab Med, 2015, 139(1):55-66. https:\/\/doi.org\/10.5858\/arpa.2014-0167-RA","DOI":"10.5858\/arpa.2014-0167-RA"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"[31] Sayar I, Peker K, Gelincik I, Demirtas L, Isik A. Clear cell variant of follicular thyroid carcinoma with normal thyroid-stimulating hormone value: a case report. J Med Case Rep, 2014, 8:160. https:\/\/doi.org\/10.1186\/1752-1947-8-160","DOI":"10.1186\/1752-1947-8-160"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"[32] Aung MTZ, Kim JE, Yoon HJ, Huh KH, Yi WJ, Heo MS, Lee SS. Primary malignant melanoma of the parotid gland, a rare case arising from a duct: a case report and literature review. Front Oncol, 2024, 14:1324214. https:\/\/doi.org\/10.3389\/fonc.2024.1324214","DOI":"10.3389\/fonc.2024.1324214"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"[33] Ahadi M, Rakhshan A, Mousavi SR, Saebnoori H. Malignant melanoma of parotid glands from a neglected lesion: a case report. Clin Case Rep, 2021, 9(10):e04941. https:\/\/doi.org\/10.1002\/ccr3.4941","DOI":"10.1002\/ccr3.4941"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"[34] Trandafir CM, Closca RM, Poenaru M, Sarau OS, Sarau CA, Rakitovan M, Baderca F, Sima LV. Morphological and immunohistochemical aspects with prognostic implications and therapeutic targets of primary sinonasal mucosal melanoma: a retrospective study. Cancers (Basel), 2024, 16(16):2863. https:\/\/doi.org\/10.3390\/cancers16162863","DOI":"10.3390\/cancers16162863"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"[35] Kundu S, Eynon-Lewis NJ, Radcliffe GJ. Extensive metastatic renal cell carcinoma presenting as facial nerve palsy. J Laryngol Otol, 2001, 115(6):488-490. https:\/\/doi.org\/10.1258\/0022215011908009","DOI":"10.1258\/0022215011908009"},{"key":"ref35","unstructured":"[36] Spreafico R, Nicoletti G, Ferrario F, Scanziani R, Grasso M. Parotid metastasis from renal cell carcinoma: a case report and review of the literature. Acta Otorhinolaryngol Ital, 2008, 28(5):266-268."},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"[37] Park YW, Hlivko TJ. Parotid gland metastasis from renal cell carcinoma. Laryngoscope, 2002, 112(3):453-456. https:\/\/doi.org\/10.1097\/00005537-200203000-00009","DOI":"10.1097\/00005537-200203000-00009"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"[38] Deeb R, Zhang Z, Kini S, Ghanem T. Metastatic renal cell carcinoma to the parotid gland presenting 19 years after nephrectomy: case report and review of literature. Laryngoscope, 2010, 120(Suppl 4):S128. https:\/\/doi.org\/10.1002\/lary.21592","DOI":"10.1002\/lary.21592"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"[39] Ito R, Nishiike S, Tomiyama Y, Yoshii T, Yamamoto Y, Inohara H. [Three cases of renal cell carcinoma metastasizing to the head and neck]. Nippon Jibiinkoka Gakkai Kaiho, 2011, 114(11):864-868. https:\/\/doi.org\/10.3950\/jibiinkoka.114.864","DOI":"10.3950\/jibiinkoka.114.864"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"[40] Pisani P, Krengli M, Ramponi A, Guglielmetti R, Pia F. Metastases to parotid gland from cancers of the upper airway and digestive tract. Br J Oral Maxillofac Surg, 1998, 36(1):54-57. https:\/\/doi.org\/10.1016\/S0266-4356(98)90750-1","DOI":"10.1016\/S0266-4356(98)90750-1"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"[41] Palmisciano P, Ferini G, Ogasawara C, Wahood W, Bin Alamer O, Gupta AD, Scalia G, Larsen AMG, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS. Orbital metastases: a systematic review of clinical characteristics, management strategies, and treatment outcomes. Cancers (Basel), 2021, 14(1):94. https:\/\/doi.org\/10.3390\/cancers14010094","DOI":"10.3390\/cancers14010094"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"[42] Labrador AJP, Marin NRG, Valdez LHM, Sanchez KBT, Zabarburu W, Ibazetta KAR, Garcia AER, Cabezas DM, Romero L, Conte AM, Wright JM. Metastasis to the oral and maxillofacial region. A systematic review. J Stomatol Oral Maxillofac Surg, 2022, 123(5):e474-e483. https:\/\/doi.org\/10.1016\/j.jormas.2021.12.009","DOI":"10.1016\/j.jormas.2021.12.009"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"[43] Kamieniarz L, Armeni E, O'Mahony LF, Leigh C, Miah L, Narayan A, Bhatt A, Cox N, Mandair D, Navalkissoor S, Caplin M, Toumpanakis C. Orbital metastases from neuroendocrine neoplasms: clinical implications and outcomes. Endocrine, 2020, 67(2):485-493. https:\/\/doi.org\/10.1007\/s12020-019-02130-5","DOI":"10.1007\/s12020-019-02130-5"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"[44] Tailor TD, Gupta D, Dalley RW, Keene CD, Anzai Y. Orbital neoplasms in adults: clinical, radiologic, and pathologic review. RadioGraphics, 2013, 33(6):1739-1758. https:\/\/doi.org\/10.1148\/rg.336135502","DOI":"10.1148\/rg.336135502"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"[45] Shields JA, Shields CL, Ehya H, Eagle RC Jr, De Potter P. Fine-needle aspiration biopsy of suspected intraocular tumors. The 1992 Urwick Lecture. Ophthalmology, 1993, 100(11):1677-1684. https:\/\/doi.org\/10.1016\/s0161-6420(93)31418-1","DOI":"10.1016\/S0161-6420(93)31418-1"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"[46] Wladis EJ, Lee KW, Nazeer T. Metastases of systemic malignancies to the orbit: a major review. Orbit, 2021, 40(2):93-97. https:\/\/doi.org\/10.1080\/01676830.2020.1759110","DOI":"10.1080\/01676830.2020.1759110"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"[47] Tsagkaraki IM, Kourouniotis CD, Gomatou GL, Syrigos NK, Kotteas EA. Orbital metastases of invasive lobular breast carcinoma. Breast Dis, 2019, 38(3-4):85-91. https:\/\/doi.org\/10.3233\/BD-190398","DOI":"10.3233\/BD-190398"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"[48] Sklar BA, Gervasio KA, Karmazin K, Wu AY. Orbital metastasis from urothelial carcinoma: a comprehensive literature review. Ophthalmic Plast Reconstr Surg, 2019, 35(3):213-217. https:\/\/doi.org\/10.1097\/IOP.0000000000001256","DOI":"10.1097\/IOP.0000000000001256"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"[49] Newman SA. Orbital surgery: evolution and revolution. J Neurol Surg B Skull Base, 2021, 82(1):7-19. https:\/\/doi.org\/10.1055\/s-0040-1722704","DOI":"10.1055\/s-0040-1722704"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"[50] Martel A, Baillif S, Nahon-Esteve S, Gastaud L, Bertolotto C, Lassalle S, Lagier J, Hamedani M, Poissonnet G. Orbital exenteration: an updated review with perspectives. Surv Ophthalmol, 2021, 66(5):856-876. https:\/\/doi.org\/10.1016\/j.survophthal.2021.01.008","DOI":"10.1016\/j.survophthal.2021.01.008"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"[51] Traylor JI, Christiano LD, Esmaeli B, Hanasono MM, Yu P, Suki D, Zhang W, Raza SM, Hanna EY, DeMonte F. Outcomes of orbital exenteration for craniofacial lesions. Cancer, 2021, 127(14):2465-2475. https:\/\/doi.org\/10.1002\/cncr.33526","DOI":"10.1002\/cncr.33526"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"[52] Sindoni A, Fama F, Vinciguerra P, Dionigi G, Manara SAAM, Gaeta R, Gioffre'-Florio M, Di Maria A. Orbital metastases from breast cancer: a single institution case series. J Surg Oncol, 2020, 122(2):170-175. https:\/\/doi.org\/10.1002\/jso.25927","DOI":"10.1002\/jso.25927"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"[53] Ioakeim-Ioannidou M, MacDonald SM. Evolution of care of orbital tumors with radiation therapy. J Neurol Surg B Skull Base, 2020, 81(4):480-496. https:\/\/doi.org\/10.1055\/s-0040-1713894","DOI":"10.1055\/s-0040-1713894"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"[54] Ahmad SM, Esmaeli B. Metastatic tumors of the orbit and ocular adnexa. Curr Opin Ophthalmol, 2007, 18(5):405-413. https:\/\/doi.org\/10.1097\/ICU.0b013e3282c5077c","DOI":"10.1097\/ICU.0b013e3282c5077c"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"[55] Shields JA, Shields CL, Brotman HK, Carvalho C, Perez N, Eagle RC Jr. Cancer metastatic to the orbit: the 2000 Robert M. Curts Lecture. Ophthalmic Plast Reconstr Surg, 2001, 17(5):346-354. https:\/\/doi.org\/10.1097\/00002341-200109000-00009","DOI":"10.1097\/00002341-200109000-00009"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"[56] George B, Wirostko WJ, Connor TB, Choong NW. Complete and durable response of choroid metastasis from non-small cell lung cancer with systemic Bevacizumab and chemotherapy. J Thorac Oncol, 2009, 4(5):661-662. https:\/\/doi.org\/10.1097\/JTO.0b013e31819c9a73","DOI":"10.1097\/JTO.0b013e31819c9a73"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"[57] Manquez ME, Brown MM, Shields CL, Shields JA. Management of choroidal metastases from breast carcinomas using aromatase inhibitors. Curr Opin Ophthalmol, 2006, 17(3):251-256. https:\/\/doi.org\/10.1097\/01.icu.0000193105.22960.f6","DOI":"10.1097\/01.icu.0000193105.22960.f6"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"[58] Mendia A, Shah CP, Grajo JR, Yachnis A, Yeung A, Cardenas-Goicoechea J, Murphy M. Orbital metastasis of squamous cell cervical cancer: a case report and review of literature. Gynecol Oncol Rep, 2021, 35:100689. https:\/\/doi.org\/10.1016\/j.gore.2020.100689","DOI":"10.1016\/j.gore.2020.100689"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"[59] Bullock JD, Yanes B. Ophthalmic manifestations of metastatic breast cancer. 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