{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T23:23:20Z","timestamp":1794353000020,"version":"4.9.0"},"reference-count":19,"publisher":"Societatea Romana de Morfologie","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2026,3,10]]},"abstract":"<jats:p>Acute abdominal emergencies remain a leading cause of mortality in the emergency setting, often resulting in death before surgical intervention can be performed. During the coronavirus disease 2019 (COVID-19) pandemic, these cases were further complicated by thrombotic and inflammatory mechanisms, with a notable increase in mesenteric ischemia. We conducted a retrospective monocentric study of 31 postmortem cases of acute abdomen occurring between January 1, 2019, and December 31, 2023, analyzing demographic characteristics, clinical presentation, laboratory parameters, imaging, and autopsy findings. Among 69 total deaths in the Emergency Department during this period, 31 were attributed to acute abdominal pathology, the majority involving elderly, septic patients with perforation or ischemia. Nine deaths from mesenteric ischemia occurred during the COVID-19 period, emphasizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated hypercoagulability. Other fatal cases included perforated ulcers, ruptured hepatic or pancreatic tumors, and advanced neoplasms with secondary peritonitis. Laboratory markers such as elevated lactate, leukocytosis, and coagulopathy corresponded with postmortem evidence of intestinal necrosis, thrombosis, or peritoneal contamination. Although urban patients predominated, rural patients frequently presented with advanced sepsis at admission. These findings highlight that acute abdominal emergencies carry high mortality and underscore the critical importance of early recognition, rapid triage, and multidisciplinary management. Postmortem analysis provides essential insights into fatal mechanisms and supports the refinement of diagnostic and treatment protocols to improve outcomes.<\/jats:p>","DOI":"10.47162\/rjme.66.4.03","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:10:17Z","timestamp":1774865417000},"page":"653-660","source":"Crossref","is-referenced-by-count":1,"title":["Acute abdomen: postmortem analysis of 31 cases in the Emergency Department \u2013 a monocentric retrospective study"],"prefix":"10.47162","volume":"66","author":[{"name":"Doctoral School, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Department of Surgery I, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Iosif","family":"Moldoveanu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Diana","family":"Orza\u0163\u0103","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Doctoral School, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Gheorghe","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery I, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Center of Hepato-Pancreato-Biliary Surgery, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren\u0163iu Vasile","family":"Sima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery I, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Center of Hepato-Pancreato-Biliary Surgery, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Iliescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery I, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Center of Hepato-Pancreato-Biliary Surgery, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Veniamin","family":"Cozma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery I, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Department of Thoracic Surgery, Emergency City Hospital, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovidiu Alexandru","family":"Mederle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Emergency Discipline, Department of Surgery, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Department of Surgery, Multidisciplinary Centre for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Zar\u0103","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Microscopic Morphology, Victor Babe\u015f University of Medicine and Pharmacy, Timi\u015foara, Romania; Department of Pathology, Emergency City Hospital, Timi\u015foara, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26736","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Oldenburg WA, Lau LL, Rodenberg TJ, Edmonds HJ, Burger CD. Acute mesenteric ischemia: a clinical review. Arch Intern Med, 2004, 164(10):1054-1062. https:\/\/doi.org\/10.1001\/archinte.164.10.1054","DOI":"10.1001\/archinte.164.10.1054"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"[2] Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, Mehra MR, Schuepbach RA, Ruschitzka F, Moch H. Endothelial cell infection and endotheliitis in COVID-19. Lancet, 2020, 395(10234):1417-1418. https:\/\/doi.org\/10.1016\/S0140-6736(20)30937-5","DOI":"10.1016\/S0140-6736(20)30937-5"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"[3] Kaur P, Qaqa F, Ramahi A, Shamoon Y, Singhal M, Shamoon F, Maroules M, Singh B. Acute upper limb ischemia in a patient with COVID-19. Hematol Oncol Stem Cell Ther, 2021, 14(4):348-350. https:\/\/doi.org\/10.1016\/j.hemonc.2020.05.001","DOI":"10.1016\/j.hemonc.2020.05.001"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"[4] Becker RC. COVID-19 update: Covid-19-associated coagulopathy. J Thromb Thrombolysis, 2020, 50(1):54-67. https:\/\/doi.org\/10.1007\/s11239-020-02134-3","DOI":"10.1007\/s11239-020-02134-3"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"[5] Norsa L, Valle C, Morotti D, Bonaffini PA, Indriolo A, Sonzogni A. Intestinal ischemia in the COVID-19 era. Dig Liver Dis, 2020, 52(10):1090-1091. https:\/\/doi.org\/10.1016\/j.dld.2020.05.030","DOI":"10.1016\/j.dld.2020.05.030"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"[6] Menke J. Diagnostic accuracy of multidetector CT in acute mesenteric ischemia: systematic review and meta-analysis. Radiology, 2010, 256(1):93-101. https:\/\/doi.org\/10.1148\/radiol.10091938","DOI":"10.1148\/radiol.10091938"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"[7] Acosta S. Mesenteric ischemia. Curr Opin Crit Care, 2015, 21(2):171-178. https:\/\/doi.org\/10.1097\/MCC.0000000000000189","DOI":"10.1097\/MCC.0000000000000189"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"[8] Bala M, Kashuk J, Moore EE, Kluger Y, Biffl W, Gomes CA, Ben-Ishay O, Rubinstein C, Balogh ZJ, Civil I, Coccolini F, Leppaniemi A, Peitzman A, Ansaloni L, Sugrue M, Sartelli M, Di Saverio S, Fraga GP, Catena F. Acute mesenteric ischemia: guidelines of the World Society of Emergency Surgery. World J Emerg Surg, 2017, 12:38. https:\/\/doi.org\/10.1186\/s13017-017-0150-5","DOI":"10.1186\/s13017-017-0150-5"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"[9] Kase K, Reintam Blaser A, Tamme K, M\u00e4ndul M, Forbes A, Talving P, Murruste M. Epidemiology of acute mesenteric ischemia: a population-based investigation. World J Surg, 2023, 47(1):173-181. https:\/\/doi.org\/10.1007\/s00268-022-06805-5","DOI":"10.1007\/s00268-022-06805-5"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"[10] Singh B, Kaur P. COVID-19 and acute mesenteric ischemia: a review of current literature. Hematol Transfus Cell Ther, 2021, 43(1):112-116. https:\/\/doi.org\/10.1016\/j.htct.2020.10.959","DOI":"10.1016\/j.htct.2020.10.959"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"[11] Bj\u00f6rck M, Wanhainen A. Non-occlusive mesenteric hypoperfusion syndromes: recognition and treatment. Semin Vasc Surg, 2010, 23(1):54-64. https:\/\/doi.org\/10.1053\/j.semvascsurg.2009.12.009","DOI":"10.1053\/j.semvascsurg.2009.12.009"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"[12] Acosta S, Block T, Bj\u00f6rnsson S, Resch T, Bj\u00f6rck M, Nilsson T. Diagnostic pitfalls at admission in patients with acute superior mesenteric artery occlusion. J Emerg Med, 2012, 42(6):635-641. https:\/\/doi.org\/10.1016\/j.jemermed.2011.03.036","DOI":"10.1016\/j.jemermed.2011.03.036"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"[13] Vrba R, \u0158ez\u00e1\u010d T, \u0160pi\u010dka P, Klos D, \u010cern\u00e1 M, K\u00f6cher M. Acute mesenteric ischaemia in the elderly - results of combined endovascular and surgical treatment. Primary study. Sci Rep, 2025, 15(1):74. https:\/\/doi.org\/10.1038\/s41598-024-84026-7","DOI":"10.1038\/s41598-024-84026-7"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"[14] Kaafarani HMA, El Moheb M, Hwabejire JO, Naar L, Christensen MA, Breen K, Gaitanidis A, Alser O, Mashbari H, Bankhead-Kendall B, Mokhtari A, Maurer L, Kapoen C, Langeveld K, El Hechi MW, Lee J, Mendoza AE, Saillant NN, Parks J, Fawley J, King DR, Fagenholz PJ, Velmahos GC. Gastrointestinal complications in critically ill patients with COVID-19. Ann Surg, 2020, 272(2):e61-e62. https:\/\/doi.org\/10.1097\/SLA.0000000000004004","DOI":"10.1097\/SLA.0000000000004004"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"[15] Patel S, Parikh C, Verma D, Sundararajan R, Agrawal U, Bheemisetty N, Akku R, S\u00e1nchez-Velazco D, Waleed MS. Bowel ischaemia in COVID-19: a systematic review. Int J Clin Pract, 2021, 75(12):e14930. https:\/\/doi.org\/10.1111\/ijcp.14930","DOI":"10.1111\/ijcp.14930"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"[16] Bj\u00f6rck M, Koelemay M, Acosta S, Bastos Goncalves F, K\u00f6lbel T, Kolkman JJ, Lees T, Lefevre JH, Menyhei G, Oderich G, Esvs Guidelines Committee, Kolh P, de Borst GJ, Chakfe N, Debus S, Hinchliffe R, Kakkos S, Koncar I, Sanddal Lindholt J, Vega de Ceniga M, Vermassen F, Verzini F, Document Reviewers, Geelkerken B, Gloviczki P, Huber T, Naylor R. Editor's Choice - Management of the diseases of mesenteric arteries and veins: Clinical Practice Guidelines of the European Society of Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg, 2017, 53(4):460-510. https:\/\/doi.org\/10.1016\/j.ejvs.2017.01.010","DOI":"10.1016\/j.ejvs.2017.01.010"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"[17] S\u00f8reide K, Thorsen K, Harrison EM, Bingener J, M\u00f8ller MH, Ohene-Yeboah M, S\u00f8reide JA. Perforated peptic ulcer. Lancet, 2015, 386(10000):1288-1298. https:\/\/doi.org\/10.1016\/S0140-6736(15)00276-7","DOI":"10.1016\/S0140-6736(15)00276-7"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"[18] Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med, 2020, 383(2):120-128. https:\/\/doi.org\/10.1056\/NEJMoa2015432","DOI":"10.1056\/NEJMoa2015432"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"[19] Sartelli M, Catena F, Ansaloni L, Coccolini F, Corbella D, Moore EE, Malangoni M, Velmahos G, Coimbra R, Koike K, Leppaniemi A, Biffl W, Balogh Z, Bendinelli C, Gupta S, Kluger Y, Agresta F, Di Saverio S, Tugnoli G, Jovine E, Ordonez CA, Whelan JF, Fraga GP, Gomes CA, Pereira GA, Yuan KC, Bala M, Peev MP, Ben-Ishay O, Cui Y, Marwah S, Zachariah S, Wani I, Rangarajan M, Sakakushev B, Kong V, Ahmed A, Abbas A, Gonsaga RA, Guercioni G, Vettoretto N, Poiasina E, D\u00edaz-Nieto R, Massalou D, Skrovina M, Gerych I, Augustin G, Kenig J, Khokha V, Tran\u00e0 C, Kok KY, Mefire AC, Lee JG, Hong SK, Lohse HA, Ghnnam W, Verni A, Lohsiriwat V, Siribumrungwong B, El Zalabany T, Tavares A, Baiocchi G, Das K, Jarry J, Zida M, Sato N, Murata K, Shoko T, Irahara T, Hamedelneel AO, Naidoo N, Adesunkanmi AR, Kobe Y, Ishii W, Oka K, Izawa Y, Hamid H, Khan I, Attri A, Sharma R, Sanjuan J, Badiel M, Barnab\u00e9 R. Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study. 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