{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:39:15Z","timestamp":1788381555728,"version":"build-2803163510"},"reference-count":62,"publisher":"Societatea Romana de Morfologie","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2026,7,10]]},"abstract":"<jats:p>Background\/Objectives: Primary cutaneous extraskeletal Ewing sarcoma (pcEES) is an exceptionally rare malignant small round cell tumor, with limited cases reported and challenging diagnosis due to overlapping clinicopathological features. We aimed to review its diagnostic and therapeutic aspects and present a rare plantar case. Study selection for review: A PubMed search was performed to evaluate current data regarding the epidemiology, diagnosis, differential diagnosis, and management of pcEES. Case presentation: A 62-year-old woman with recurrent pcEES of the left plantar region presented with severe pain, ulceration, superinfection, inguinal lymph node involvement, and suspected osseous invasion. Histopathology and immunohistochemistry supported the diagnosis. Due to advanced locoregional disease, left transfemoral amputation was performed. Conclusions: pcEES is a rare and diagnostically demanding malignancy that may show aggressive behavior despite superficial location. Early diagnosis and multidisciplinary management are essential.<\/jats:p>","DOI":"10.47162\/rjme.67.1.02","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:55:06Z","timestamp":1784328906000},"page":"19-28","source":"Crossref","is-referenced-by-count":1,"title":["Primary cutaneous extraskeletal Ewing sarcoma of the plantar region: clinicopathological features and review of the literature"],"prefix":"10.47162","volume":"67","author":[{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Railway Clinical Hospital, Craiova, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren\u0163iu Augustus","family":"Barbu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Florin R\u0103zvan","family":"Mogo\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Railway Clinical Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolae Drago\u015f","family":"M\u0103rg\u0103ritescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Emergency County Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Marinescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Emergency County Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelian \u015etef\u0103ni\u0163\u0103","family":"Mogoant\u0103","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Emergency County Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liviu","family":"Vasile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Emergency County Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Cercelaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Anatomy and Embryology, University of Medicine and Pharmacy of Craiova, Romania; Department of Pathology, Emergency County Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"C\u0103luianu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Doctoral School, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana Alexia","family":"\u0162enea-Cojan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Student, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiberiu \u015etef\u0103ni\u0163\u0103","family":"\u0162enea-Cojan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Railway Clinical Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26736","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Abboud A, Masrouha K, Saliba M, Haidar R, Saab R, Khoury N, Tawil A, Saghieh S. Extraskeletal Ewing sarcoma: diagnosis, management and prognosis. Oncol Lett, 2021, 21(5):354. https:\/\/doi.org\/10.3892\/ol.2021.12615","DOI":"10.3892\/ol.2021.12615"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"[2] Suaste-Vera HU, Villalobos-Molina R. Ewing sarcoma: a comprehensive review of its classification, diagnosis, and emerging treatments. J Biosci Med, 2025, 13(8):158-187. https:\/\/doi.org\/10.4236\/jbm.2025.138014","DOI":"10.4236\/jbm.2025.138014"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"[3] Denis R, Felix M, Mejia D, Hobbs M, Alvarez P, Casadesus D. Extraskeletal Ewing sarcoma: a case report. Cureus, 2024, 16(2):e55077. https:\/\/doi.org\/10.7759\/cureus.55077","DOI":"10.7759\/cureus.55077"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"[4] Cash T, McIlvaine E, Krailo MD, Lessnick SL, Lawlor ER, Laack N, Sorger J, Marina N, Grier HE, Granowetter L, Womer RB, DuBois SG. Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer, 2016, 63(10):1771-1779. https:\/\/doi.org\/10.1002\/pbc.26096","DOI":"10.1002\/pbc.26096"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"[5] Applebaum MA, Worch J, Matthay KK, Goldsby R, Neuhaus J, West DC, Dubois SG. Clinical features and outcomes in patients with extraskeletal Ewing sarcoma. Cancer, 2011, 117(13):3027-3032. https:\/\/doi.org\/10.1002\/cncr.25840","DOI":"10.1002\/cncr.25840"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"[6] Wang S, Zhu W, Zhang H, Yang X. Extraosseous Ewing sarcoma of the cervical esophagus: case report and literature review. Ear Nose Throat J, 2022, 101(5):NP203-NP208. https:\/\/doi.org\/10.1177\/0145561320953696","DOI":"10.1177\/0145561320953696"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"[7] Daley J, Williams N, Salgado CM, Schultz C, Meade J, Ozolek J, Lindsey B, Bailey KM. Cutaneous Ewing sarcoma presenting as a second primary malignancy in a child. J Pediatr Hematol Oncol, 2022, 44(8):486-488. https:\/\/doi.org\/10.1097\/mph.0000000000002457","DOI":"10.1097\/MPH.0000000000002457"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"[8] Hammedi F, Ziadi S, Trimeche M, Jomaa W, Sriha B, Korbi S. Primary subcutaneous Ewing sarcoma presented as pseudo aneurysmal subcutaneous tumor. World J Oncol, 2010, 1(1):47-49. https:\/\/doi.org\/10.4021\/wjon2010.01.1205","DOI":"10.4021\/wjon2010.01.1205"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"[9] Styczewska M, Lyzinska W, Wardecki SM, Zajaczkowska J, Kunc M, Mikaszewski B, Maciag R, Regent B, Wyrzykowski D, Jankowska A, Swieton D, Sinacka K, Zak-Jasinska K, Jedrzejczyk A, Krawczyk MA, Bien E. Diagnostic pitfalls: soft-tissue sarcomas initially misdiagnosed as benign vascular anomalies - a case report and systematic review. Oncol Rev, 2025, 19:1681090. https:\/\/doi.org\/10.3389\/or.2025.1681090","DOI":"10.3389\/or.2025.1681090"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"[10] Al-Rohil RN, Cloutier JM, Ko JS, Patel RM, Linos K. Immunohistochemical and molecular testing for the diagnosis of primary cutaneous Ewing sarcoma: a comprehensive review. J Cutan Pathol, 2026, 53(3):302-309. https:\/\/doi.org\/10.1111\/cup.70030","DOI":"10.1111\/cup.70030"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"[11] Z\u00f6llner SK, Amatruda JF, Bauer S, Collaud S, de \u00c1lava E, DuBois SG, Hardes J, Hartmann W, Kovar H, Metzler M, Shulman DS, Streitb\u00fcrger A, Timmermann B, Toretsky JA, Uhlenbruch Y, Vieth V, Gr\u00fcnewald TGP, Dirksen U. Ewing sarcoma - diagnosis, treatment, clinical challenges and future perspectives. J Clin Med, 2021, 10(8):1685. https:\/\/doi.org\/10.3390\/jcm10081685","DOI":"10.3390\/jcm10081685"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"[12] Wiemels JL, Wang R, Feng Q, Yee AC, Morimoto LM, Metayer C, Ma X. Birth characteristics and risk of Ewing sarcoma. Cancer Causes Control, 2023, 34(10):837-843. https:\/\/doi.org\/10.1007\/s10552-023-01737-4","DOI":"10.1007\/s10552-023-01737-4"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"[13] Ali RH, Mohammed EMA, Ahmed AA, Alsaber AR, Al-Otaibi HS, Abdulmoneim SAK, Hassan A, Almousawi F, Khalifa N, Ali AA, Bahzad S, Alenezi FG, AlNassar M, AlJassim A. Age-related clinicopathologic patterns in Ewing sarcoma (FET::ETS family): a comparative analysis of pediatric and adult patients. Cancers (Basel), 2025, 18(1):133. https:\/\/doi.org\/10.3390\/cancers18010133","DOI":"10.3390\/cancers18010133"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"[14] Khan S, Abid Z, Haider G, Bukhari N, Zehra D, Hashmi M, Abid M, Ibrahim U. Incidence of Ewing's sarcoma in different age groups, their associated features, and its correlation with primary care interval. Cureus, 2021, 13(3):e13986. https:\/\/doi.org\/10.7759\/cureus.13986","DOI":"10.7759\/cureus.13986"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"[15] Randall RL, Lessnick SL, Jones KB, Gouw LG, Cummings JE, Cannon-Albright L, Schiffman JD. Is there a predisposition gene for Ewing's sarcoma? J Oncol, 2010, 2010:397632. https:\/\/doi.org\/10.1155\/2010\/397632","DOI":"10.1155\/2010\/397632"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"[16] Flucke U, van Noesel MM, Siozopoulou V, Creytens D, Tops BBJ, van Gorp JM, Hiemcke-Jiwa LS. EWSR1 - the most common rearranged gene in soft tissue lesions, which also occurs in different bone lesions: an updated review. Diagnostics (Basel), 2021, 11(6):1093. https:\/\/doi.org\/10.3390\/diagnostics11061093","DOI":"10.3390\/diagnostics11061093"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"[17] Sultan I, Rihani R, Hazin R, Rodriguez-Galindo C. Second malignancies in patients with Ewing sarcoma family of tumors: a population-based study. Acta Oncol, 2010, 49(2):237-244. https:\/\/doi.org\/10.3109\/02841860903253538","DOI":"10.3109\/02841860903253538"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"[18] Abbott D, O'Brien S, Farnham JM, Young EL, Yap J, Jones K, Lessnick SL, Randall RL, Schiffman JD, Cannon-Albright LA. Increased risk for other cancers in individuals with Ewing sarcoma and their relatives. Cancer Med, 2019, 8(18):7924-7930. https:\/\/doi.org\/10.1002\/cam4.2575","DOI":"10.1002\/cam4.2575"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"[19] Pisconti S, Della Vittoria Scarpati G, Buonerba C, Messinese S, Carella R, Di Marzo M, Di Lorenzo G, Lazzari G, Perri F, Solla R. Management of Ewing sarcoma family of tumors: a short description of a rare primitive uterine pPNET and literature review. Onco Targets Ther, 2020, 13:1179-1184. https:\/\/doi.org\/10.2147\/OTT.S213233","DOI":"10.2147\/OTT.S213233"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"[20] Yoshida A. Ewing and Ewing-like sarcomas: a morphological guide through genetically-defined entities. Pathol Int, 2023, 73(1):12-26. https:\/\/doi.org\/10.1111\/pin.13293","DOI":"10.1111\/pin.13293"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"[21] Tsokos M, Alaggio RD, Dehner LP, Dickman PS. Ewing sarcoma\/peripheral primitive neuroectodermal tumor and related tumors. Pediatr Dev Pathol, 2012, 15(1 Suppl):108-126. https:\/\/doi.org\/10.2350\/11-08-1078-PB.1","DOI":"10.2350\/11-08-1078-PB.1"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"[22] Aldabbas MA, Alshorman MM, Albudour LN, Al Fohili ZM, Al-Malahmeh TN. Extraskeletal Ewing sarcoma mimicking benign soft tissue tumors: a rare case. Cureus, 2025, 17(11):e98009. https:\/\/doi.org\/10.7759\/cureus.98009","DOI":"10.7759\/cureus.98009"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"[23] Hu X, Zhao W, Yu R, Pan D. Case report: extra skeletal Ewing's sarcoma of mediastinum: clinical experience and literature review. Front Oncol, 2025, 15:1601648. https:\/\/doi.org\/10.3389\/fonc.2025.1601648","DOI":"10.3389\/fonc.2025.1601648"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"[24] Bashiri S, Heidar H, Parvin M. Extraskeletal Ewing sarcoma: report of an extremely rare case in temporal region. J Dent (Tehran), 2018, 15(6):393-395.","DOI":"10.18502\/jdt.v15i6.333"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"[25] Kourda M, Chatti S, Sfia M, Kraiem W, Ben Brahim E. Sarcome d'Ewing \u00e0 localisation cutan\u00e9e primitive [Primary cutaneous extraskeletal Ewing's sarcoma]. Ann Dermatol Venereol, 2005, 132(12 Pt 1):986-989. https:\/\/doi.org\/10.1016\/s0151-9638(05)79562-4","DOI":"10.1016\/S0151-9638(05)79562-4"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"[26] Oliveira Filho J, Tebet AC, Oliveira AR, Nasser K. Primary cutaneous Ewing sarcoma - case report. An Bras Dermatol, 2014, 89(3):501-503. https:\/\/doi.org\/10.1590\/abd1806-4841.20142881","DOI":"10.1590\/abd1806-4841.20142881"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"[27] Gao L, Zhu Y, Shi X, Gao Z, Chen X. Peripheral primitive neuroectodermal tumors: a retrospective analysis of 89 cases and literature review. Oncol Lett, 2019, 18(6):6885-6890. https:\/\/doi.org\/10.3892\/ol.2019.11011. Erratum in: Oncol Lett, 2020, 19(4):3035. https:\/\/doi.org\/10.3892\/ol.2020.11385","DOI":"10.3892\/ol.2020.11385"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"[28] Chinchilla-T\u00e1bora LM, Ortiz Rodr\u00edguez-Parets J, Gonz\u00e1lez Morais I, Sayagu\u00e9s JM, Lude\u00f1a de la Cruz MD. Immunohistochemical analysis of CD99 and PAX8 in a series of 15 molecularly confirmed cases of Ewing sarcoma. Sarcoma, 2020, 2020:3180798. https:\/\/doi.org\/10.1155\/2020\/3180798","DOI":"10.1155\/2020\/3180798"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"[29] Shibuya R, Matsuyama A, Nakamoto M, Shiba E, Kasai T, Hisaoka M. The combination of CD99 and NKX2.2, a transcriptional target of EWSR1-FLI1, is highly specific for the diagnosis of Ewing sarcoma. Virchows Arch, 2014, 465(5):599-605. https:\/\/doi.org\/10.1007\/s00428-014-1627-1","DOI":"10.1007\/s00428-014-1627-1"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"[30] Sassi F, M\u00e9tais A, Varlet P, Berthaud C, Pucelle N, Mandoula M, Dababou Z, Carnes N, Hasty L, Collard A, Chr\u00e9tien F, Tauzi\u00e8de-Espariat A. Diagnostic utility of NKX2.2 and CD99 in the central nervous system to distinguish Ewing sarcoma from its mimickers. Acta Neuropathol Commun, 2025, 13(1):243. https:\/\/doi.org\/10.1186\/s40478-025-02178-7","DOI":"10.1186\/s40478-025-02178-7"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"[31] Wei S, Siegal GP. Small round cell tumors of soft tissue and bone. Arch Pathol Lab Med, 2022, 146(1):47-59. https:\/\/doi.org\/10.5858\/arpa.2020-0773-RA","DOI":"10.5858\/arpa.2020-0773-RA"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"[32] Haiduk II, Dakhtler TE, Khaibullina PR, Kiselev HY, Valkov AY. Primary cutaneous Ewing sarcoma with unusual features: potential mimic of Merkel cell carcinoma. Am J Dermatopathol, 2026, Jan 16. https:\/\/doi.org\/10.1097\/dad.0000000000003218","DOI":"10.1097\/DAD.0000000000003218"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"[33] Carter RL, al-Sams SZ, Corbett RP, Clinton S. A comparative study of immunohistochemical staining for neuron-specific enolase, protein gene product 9.5 and S-100 protein in neuroblastoma, Ewing's sarcoma and other round cell tumours in children. Histopathology, 1990, 16(5):461-467. https:\/\/doi.org\/10.1111\/j.1365-2559.1990.tb01545.x","DOI":"10.1111\/j.1365-2559.1990.tb01545.x"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"[34] Xu X, Palsgrove D, Kurian E, Yan S, Oliai BR, Bishop JA. Variable expression of S100 protein in sinonasal malignant mucosal melanoma: a potential diagnostic pitfall. Head Neck Pathol, 2020, 14(4):929-935. https:\/\/doi.org\/10.1007\/s12105-020-01158-8","DOI":"10.1007\/s12105-020-01158-8"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"[35] Bellizzi AM. An algorithmic immunohistochemical approach to define tumor type and assign site of origin. Adv Anat Pathol, 2020, 27(3):114-163. https:\/\/doi.org\/10.1097\/pap.0000000000000256","DOI":"10.1097\/PAP.0000000000000256"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"[36] Yoshida A, Sekine S, Tsuta K, Fukayama M, Furuta K, Tsuda H. NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma. Am J Surg Pathol, 2012, 36(7):993-999. https:\/\/doi.org\/10.1097\/PAS.0b013e31824ee43c","DOI":"10.1097\/PAS.0b013e31824ee43c"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"[37] Yamaguchi U, Hasegawa T, Morimoto Y, Tateishi U, Endo M, Nakatani F, Kawai A, Chuman H, Beppu Y, Endo M, Kurotaki H, Furuta K. A practical approach to the clinical diagnosis of Ewing's sarcoma\/primitive neuroectodermal tumour and other small round cell tumours sharing EWS rearrangement using new fluorescence in situ hybridisation probes for EWSR1 on formalin fixed, paraffin wax embedded tissue. J Clin Pathol, 2005, 58(10):1051-1056. https:\/\/doi.org\/10.1136\/jcp.2004.025502","DOI":"10.1136\/jcp.2004.025502"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"[38] Boland JM, Folpe AL. Cutaneous neoplasms showing EWSR1 rearrangement. Adv Anat Pathol, 2013, 20(2):75-85. https:\/\/doi.org\/10.1097\/PAP.0b013e31828625bf","DOI":"10.1097\/PAP.0b013e31828625bf"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"[39] Rajwanshi A, Srinivas R, Upasana G. Malignant small round cell tumors. J Cytol, 2009, 26(1):1-10. https:\/\/doi.org\/10.4103\/0970-9371.54861","DOI":"10.4103\/0970-9371.54861"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"[40] Skapek SX, Ferrari A, Gupta AA, Lupo PJ, Butler E, Shipley J, Barr FG, Hawkins DS. Rhabdomyosarcoma. Nat Rev Dis Primers, 2019, 5(1):1. https:\/\/doi.org\/10.1038\/s41572-018-0051-2","DOI":"10.1038\/s41572-018-0051-2"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"[41] Becker JC, Stang A, DeCaprio JA, Cerroni L, Lebb\u00e9 C, Veness M, Nghiem P. Merkel cell carcinoma. Nat Rev Dis Primers, 2017, 3:17077. https:\/\/doi.org\/10.1038\/nrdp.2017.77","DOI":"10.1038\/nrdp.2017.77"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"[42] Hornback CJ, Cintolo-Gonzalez J, LeBoit PE, Greene LA, Barker J. Dermal cutaneous clear cell sarcoma defined by novel EWSR1-CREM fusion. JAAD Case Rep, 2024, 52:162-165. https:\/\/doi.org\/10.1016\/j.jdcr.2024.06.026","DOI":"10.1016\/j.jdcr.2024.06.026"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"[43] Liang L, Tatevian N, Bhattacharjee M, Tsao K, Hicks J. Desmoplastic small round cell tumor with atypical immunohistochemical profile and rhabdoid-like differentiation. World J Clin Cases, 2014, 2(8):367-372. https:\/\/doi.org\/10.12998\/wjcc.v2.i8.367","DOI":"10.12998\/wjcc.v2.i8.367"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"[44] Hung YP, Lee JP, Bellizzi AM, Hornick JL. PHOX2B reliably distinguishes neuroblastoma among small round blue cell tumours. Histopathology, 2017, 71(5):786-794. https:\/\/doi.org\/10.1111\/his.13288","DOI":"10.1111\/his.13288"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"[45] Zou YS, Morsberger L, Hardy M, Ghabrial J, Stinnett V, Murry JB, Long P, Kim A, Pratilas CA, Llosa NJ, Ladle BH, Lemberg KM, Levin AS, Morris CD, Haley L, Gocke CD, Gross JM. Complex\/cryptic EWSR1::FLI1\/ERG gene fusions and 1q jumping translocation in pediatric Ewing sarcomas. Genes (Basel), 2023, 14(6):1139. https:\/\/doi.org\/10.3390\/genes14061139","DOI":"10.3390\/genes14061139"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"[46] Berger M, Dirksen U, Braeuninger A, Koehler G, Juergens H, Krumbholz M, Metzler M. Genomic EWS-FLI1 fusion sequences in Ewing sarcoma resemble breakpoint characteristics of immature lymphoid malignancies. PLoS One, 2013, 8(2):e56408. https:\/\/doi.org\/10.1371\/journal.pone.0056408","DOI":"10.1371\/journal.pone.0056408"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"[47] Lee JW, Kim DM, Lee JY, Yoon TY. A case of primary cutaneous extraskeletal Ewing sarcoma on the abdomen. Ann Dermatol, 2022, 34(1):72-75. https:\/\/doi.org\/10.5021\/ad.2022.34.1.72","DOI":"10.5021\/ad.2022.34.1.72"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"[48] Rodr\u00edguez-Mart\u00edn C, Alonso J. Molecular approaches to diagnosis in Ewing sarcoma: RT-PCR. Methods Mol Biol, 2021, 2226:85-103. https:\/\/doi.org\/10.1007\/978-1-0716-1020-6_7","DOI":"10.1007\/978-1-0716-1020-6_7"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"[49] Grossetete S, Zaidi S, Orth MF, Morice S, Laud K, Louis-Brennetot C, Ferre AS, Perrin V, Cidre-Aranaz F, Raynal V, Aynaud MM, Baulande S, Wachtel M, Janoueix-Lerosey I, Brunet E, Gr\u00fcnewald TGP, Delattre O, Surdez D. The hegemonic EWSR1::ETS oncoprotein overrules core regulatory circuitry principles in Ewing sarcoma. NPJ Precis Oncol, 2025, 10(1):36. https:\/\/doi.org\/10.1038\/s41698-025-01226-8","DOI":"10.1038\/s41698-025-01226-8"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"[50] Barbu LA, Cercelaru L, \u015eurlin V, Mogoant\u0103 SS, \u0162enea Cojan TS, Marinescu D, M\u0103rg\u0103ritescu ND, Vasile L. Ki-67 and tumor size in small bowel tumors: findings from an exploratory immunohistochemical analysis. Life (Basel), 2025, 15(12):1894. https:\/\/doi.org\/10.3390\/life15121894","DOI":"10.3390\/life15121894"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"[51] Vasile L, Barbu LA, Mogo\u015f GFR, \u015eurlin V, V\u00eelcea ID, Cercelaru L, Mogoant\u0103 S\u015e, M\u0103rg\u0103ritescu ND, Nimigean V, Nimigean VR, \u0162enea-Cojan T\u015e. Neuroendocrine tumors of the appendix: a comprehensive review of the literature and case presentation. Rom J Morphol Embryol, 2025, 66(2):269-278. https:\/\/doi.org\/10.47162\/RJME.66.2.01","DOI":"10.47162\/RJME.66.2.01"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"[52] M\u0103rg\u0103ritescu ND, Marinescu D, \u0162enea-Cojan T\u015e, Vasile L, Cercelaru L, Mogo\u015f GFR, Mogoant\u0103 S\u015e, Barbu LA. Small bowel GISTs: clinicopathological patterns and the role of inflammatory markers. Rom J Morphol Embryol, 2025, 66(3):571-580. https:\/\/doi.org\/10.47162\/RJME.66.3.14","DOI":"10.47162\/RJME.66.3.14"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"[53] Marinescu D, Barbu LA, \u0162enea Cojan TS, Tudorache \u015e, Iliescu D, Marinescu RA, Zoril\u0103 LG, \u015eurlin V. Vulvar squamous cell carcinoma: a retrospective analysis of epidemiologic characteristics, HPV status, and surgical outcomes in 35 cases. Life (Basel), 2025, 15(11):1781. https:\/\/doi.org\/10.3390\/life15111781","DOI":"10.3390\/life15111781"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"[54] Barbu LA, Cercelaru L, \u015eurlin V, Mogoant\u0103 SS, \u0162enea Cojan TS, M\u0103rg\u0103ritescu ND, \u0162enea Cojan AM, C\u0103luianu V, Mogo\u015f GFR, Vasile L. Colorectal cancer in Romania: surgical strategies, survival, and historical trends in a 302-patient cohort. Life (Basel), 2025, 15(11):1686. https:\/\/doi.org\/10.3390\/life15111686","DOI":"10.3390\/life15111686"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"[55] Marinescu D, Barbu LA, \u0162enea Cojan TS, M\u0103rg\u0103ritescu ND, Vasile L, Marinescu RA, Ramboiu DS, \u015eurlin V, Ciurea AM. Vascular changes and surgical risk in cervical vs. endometrial cancer after radiotherapy: a retrospective cohort study. Life (Basel), 2026, 16(1):71. https:\/\/doi.org\/10.3390\/life16010071","DOI":"10.3390\/life16010071"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"[56] Apte SS, Mor E, Mitchell C, Gyorki DE. Practical management of adult ultra-rare primary retroperitoneal soft tissue sarcoma: a focus on perivascular epithelioid tumours and extraosseous Ewing sarcoma. Curr Oncol, 2023, 30(7):5953-5972. https:\/\/doi.org\/10.3390\/curroncol30070445","DOI":"10.3390\/curroncol30070445"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"[57] En\u0103tescu VR, Kalinovi\u0107 R, Vlad G, Nussbaum LA, Hogea L, En\u0103tescu I, Marinescu I, Ifteni P, Simu M, Marian C, Giurgi-Oncu C, Papav\u0103 I. The presence of peripheral inflammatory markers in patients with major depressive disorder, the associated symptoms profiles and the antidepressant efficacy of Celecoxib. Farmacia, 2020, 68(3):483-491. https:\/\/doi.org\/10.31925\/farmacia.2020.3.14","DOI":"10.31925\/farmacia.2020.3.14"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"[58] Onesti CE, Vari S, Minghelli D, Nardozza F, Rossi B, Sperati F, Checcucci E, Faltyn W, Cercato MC, Cosimati A, Salvatori F, Biagini R, Ciliberto G, Ferraresi V, Maggi G. Quality of life and emotional distress in sarcoma patients diagnosed during COVID-19 pandemic: a supplementary analysis from the SarCorD study. Front Psychol, 2023, 14:1078992. https:\/\/doi.org\/10.3389\/fpsyg.2023.1078992","DOI":"10.3389\/fpsyg.2023.1078992"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"[59] Marinescu I, Marinescu D, Mogoant\u0103 L, Efrem IC, Stovicek PO. SARS-CoV-2 infection in patients with serious mental illness and possible benefits of prophylaxis with Memantine and Amantadine. Rom J Morphol Embryol, 2020, 61(4):1007-1022. https:\/\/doi.org\/10.47162\/RJME.61.4.03","DOI":"10.47162\/RJME.61.4.03"},{"key":"ref59","unstructured":"[60] Marinescu I, En\u0103tescu VR, Ghelase \u015eM, Marinescu D. Neurobiological arguments for a pathogenic multifactorial disconnective model of cognitive disorders from Alzheimer's disease in elderly people. Rom J Morphol Embryol, 2017, 58(4):1165-1173."},{"key":"ref60","doi-asserted-by":"publisher","unstructured":"[61] Stovicek PO, Friedmann C, Marinescu D, V\u0103duva IA, Bondari S, Trifu SC, Marinescu I. Mild TBI in the elderly - risk factor for rapid cognitive impairment in Alzheimer's disease. Rom J Morphol Embryol, 2020, 61(1):61-72. https:\/\/doi.org\/10.47162\/RJME.61.1.07","DOI":"10.47162\/RJME.61.1.07"},{"key":"ref61","unstructured":"[62] Bondoc EN, Marinescu D, Marinescu I, M\u0103lin RD, Stanca L, Z\u0103voi RE. Current understanding of psycho-neurobiology in depressive disorders with suicidal thoughts - translational models. Rom J Morphol Embryol, 2019, 60(2):389-402.\""}],"container-title":["Romanian Journal of Morphology and Embryology"],"original-title":[],"link":[{"URL":"https:\/\/rjme.ro\/RJME\/resources\/files\/670126019028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:57:43Z","timestamp":1784329063000},"score":1,"resource":{"primary":{"URL":"https:\/\/rjme.ro\/archive\/67\/1\/2\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,7,12]]},"published-print":{"date-parts":[[2026,7,12]]}},"URL":"https:\/\/doi.org\/10.47162\/rjme.67.1.02","relation":{},"ISSN":["1220-0522","2066-8279"],"issn-type":[{"value":"1220-0522","type":"print"},{"value":"2066-8279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]}}}