{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:04:27Z","timestamp":1784329467753,"version":"3.55.0"},"reference-count":43,"publisher":"Societatea Romana de Morfologie","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2026,7,10]]},"abstract":"<jats:p>Background: Inflammatory radicular cysts are lesions of endodontic origin in which chronic inflammation and tissue remodeling may support cyst expansion. Aim: The present study evaluated cluster of differentiation 34 (CD34) immunoexpression as a proxy of vascular remodeling and explored a digital, artificial intelligence (AI)-assisted quantification workflow. Materials and Methods: Thirty-nine inflammatory radicular cysts were processed as formalin-fixed paraffin-embedded (FFPE) specimens and immunostained with anti-CD34 antibody. Digital quantification [Deep Learning Inferred ImmunoFluorescence (DeepLIIF) and ImageJ] was performed in selected stromal areas. Lesions were stratified by cyst size (0.5\u20131.0 cm, 1.0\u20132.0 cm, &gt;2.0 cm). Results: Twenty-two of 39 cases were CD34-positive. In these cases, the mean proportion of CD34-positive nuclei increased with lesion size (6.67% in 0.5\u20131.0 cm, 15.98% in 1.0\u20132.0 cm, and 31.13% in &gt;2.0 cm). Differences among size groups were significant (Kruskal\u2013Wallis H=18.50, p=0.000096). Conclusions: Larger inflammatory radicular cysts displayed higher CD34-associated vascular signal, supporting an association between cyst size and vascular remodeling.<\/jats:p>","DOI":"10.47162\/rjme.67.1.10","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:55:06Z","timestamp":1784328906000},"page":"97-106","source":"Crossref","is-referenced-by-count":0,"title":["Vascular remodeling and microvessel density in inflammatory radicular cysts: a CD34 immunohistochemical analysis"],"prefix":"10.47162","volume":"67","author":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra C\u0103t\u0103lina","family":"Iacov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Camen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Munteanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana Andreea","family":"Diaconu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Endodontics, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru Dan","family":"Popescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Endodontics, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Boldeanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Doctoral School, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona Mihaela","family":"Liliac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Cristina","family":"Andrei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Histology, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Aurelia","family":"Mogoant\u0103","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Otorhinolaryngology, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionela Teodora","family":"Dasc\u0103lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Orthodontics, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"P\u0103tru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Legal and Malpractice, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela Jana","family":"\u0162uculin\u0103","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Endodontics, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26736","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Ertem SY, Uz F. An assessment of the distribution and prevalence of benign intraoral pathologies. Diagnostics (Basel), 2025, 15(3):350. https:\/\/doi.org\/10.3390\/diagnostics15030350","DOI":"10.3390\/diagnostics15030350"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"[2] Calabr\u00f3 DG, Portigliatti RP, Stolbizer F. Treatment of vital teeth involved in the extension of inflammatory radicular cysts: a systematic review. Acta Odontol Latinoam, 2024, 37(3):210-216. https:\/\/doi.org\/10.54589\/aol.37\/3\/210","DOI":"10.54589\/aol.37\/3\/210"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"[3] Preto KA, Reia VCB, Tobias MAS, Lara VS, Oliveira DT, Santos PSS. Radicular cyst mimetizing lateral periodontal cyst. Oral Surg Oral Med Oral Pathol Oral Radiol, 2024, 137(6):e240. https:\/\/doi.org\/10.1016\/j.oooo.2023.12.449","DOI":"10.1016\/j.oooo.2023.12.449"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"[4] Khetan RR, Reche A, Basra AS, Awghad SS. Radicular cyst: The sequelae of untreated caries. Cureus, 2024, 16(5):e60269. https:\/\/doi.org\/10.7759\/cureus.60269","DOI":"10.7759\/cureus.60269"},{"key":"ref4","unstructured":"[5] Chindia ML. Pathogenesis of odontogenic cysts: an update. East Afr Med J, 1991, 68(4):276-282."},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"[6] Bernardi L, Visioli F, N\u00f6r C, Rados PV. Radicular cyst: an update of the biological factors related to lining epithelium. J Endod, 2015, 41(12):1951-1961. https:\/\/doi.org\/10.1016\/j.joen.2015.08.036","DOI":"10.1016\/j.joen.2015.08.036"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"[7] Rios Osorio N, Caviedes-Bucheli J, Mosquera-Guevara L, Adames-Martinez JS, Gomez-Pinto D, Jimenez-Jimenez K, Avendano Maz H, Bornacelly-Mendoza S. The paradigm of the inflammatory radicular cyst: biological aspects to be considered. Eur Endod J, 2023, 8(1):20-36. https:\/\/doi.org\/10.14744\/eej.2022.26918","DOI":"10.14744\/eej.2022.26918"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"[8] Novacescu D, Dumitru CS, Zara F, Raica M, Suciu CS, Barb AC, Rakitovan M, Armega Anghelescu A, Cindrea AC, Diana S, Gaje PN. The morphogenesis, pathogenesis, and molecular regulation of human tooth development - a histological review. Int J Mol Sci, 2025, 26(13):6209. https:\/\/doi.org\/10.3390\/ijms26136209","DOI":"10.3390\/ijms26136209"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"[9] Ku\u017aniarz K, Luchowska-Kocot D, Tomaszewski T, Kurzepa J. Role of matrix metalloproteinases and their tissue inhibitors in the pathological mechanisms underlying maxillofacial cystic lesions. Biomed Rep, 2021, 15(2):65. https:\/\/doi.org\/10.3892\/br.2021.1441","DOI":"10.3892\/br.2021.1441"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"[10] Kiyani MN, Ehsan A, Yaqoob Z, Khan A, Zafar A, Tahir Y, Masood R. Clinical and histopathological pattern of radicular cysts: a retrospective study at a dental teaching hospital in Islamabad, Pakistan. J Rehman Med Inst, 2025, 11(4):171-176. https:\/\/doi.org\/10.52442\/jrmi.v11i4.855","DOI":"10.52442\/jrmi.v11i4.855"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"[11] de-Freitas CT, de-Fran\u00e7a GM, Gord\u00f3n-N\u00fa\u00f1ez MA, Santos PP, de-Lima KC, Galv\u00e3o HC. Myofibroblasts and increased angiogenesis contribute to periapical cystic injury containment and repair. Med Oral Patol Oral Cir Bucal, 2020, 25(5):e584-e591. https:\/\/doi.org\/10.4317\/medoral.23605","DOI":"10.4317\/medoral.23605"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"[12] Mathiou V, Tsiambas E, Maipas S, Thymara I, Peschos D, Lazaris AC, Kavantzas N. Impact of CD34-dependent micro vessel density on periapical odontogenic cysts. Cancer Diagn Progn, 2023, 3(2):189-193. https:\/\/doi.org\/10.21873\/cdp.10200","DOI":"10.21873\/cdp.10200"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"[13] Ghahremani P, Marino J, Dodds R, Nadeem S. DeepLIIF: an online platform for quantification of clinical pathology slides. Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit, 2022, 2022:21399-21405.","DOI":"10.1109\/CVPR52688.2022.02071"},{"key":"ref13","unstructured":"[14] Ruifrok AC, Johnston DA. Quantification of histochemical staining by color deconvolution. Anal Quant Cytol Histol, 2001, 23(4):291-299."},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"[15] Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med, 1991, 324(1):1-8. https:\/\/doi.org\/10.1056\/NEJM199101033240101","DOI":"10.1056\/NEJM199101033240101"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"[16] McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM; Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics. Reporting recommendations for tumor marker prognostic studies (REMARK). J Natl Cancer Inst, 2005, 97(16):1180-1184. https:\/\/doi.org\/10.1093\/jnci\/dji237","DOI":"10.1093\/jnci\/dji237"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"[17] Ruiz PA, Toledo OA, Nonaka CFW, Pinto LP, Souza LB. Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts. J Appl Oral Sci, 2010, 18(6):613-620. https:\/\/doi.org\/10.1590\/s1678-77572010000600013","DOI":"10.1590\/S1678-77572010000600013"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"[18] Nonaka CFW, Maia AP, Nascimento GJF, de Almeida Freitas R, Batista de Souza L, Galv\u00e3o HC. Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2008, 106(6):896-902. https:\/\/doi.org\/10.1016\/j.tripleo.2008.06.028","DOI":"10.1016\/j.tripleo.2008.06.028"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"[19] Zizzi A, Aspriello SD, Ferrante L, Stramazzotti D, Colella G, Balercia P, Lo Muzio L, Piemontese M, Goteri G, Rubini C. Immunohistochemical correlation between microvessel density and lymphoid infiltrate in radicular cysts. Oral Dis, 2013, 19(1):92-99. https:\/\/doi.org\/10.1111\/j.1601-0825.2012.01961.x","DOI":"10.1111\/j.1601-0825.2012.01961.x"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"[20] Muglali M, Komerik N, Bulut E, Yarim GF, Celebi N, Sumer M. Cytokine and chemokine levels in radicular and residual cyst fluids. J Oral Pathol Med, 2008, 37(3):185-189. https:\/\/doi.org\/10.1111\/j.1600-0714.2007.00595.x","DOI":"10.1111\/j.1600-0714.2007.00595.x"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"[21] Honma M, Hayakawa Y, Kosugi H, Koizumi F. Localization of mRNA for inflammatory cytokines in radicular cyst tissue by in situ hybridization, and induction of inflammatory cytokines by human gingival fibroblasts in response to radicular cyst contents. J Oral Pathol Med, 1998, 27(8):399-404. https:\/\/doi.org\/10.1111\/j.1600-0714.1998.tb01974.x","DOI":"10.1111\/j.1600-0714.1998.tb01974.x"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"[22] Bando Y, Henderson B, Meghji S, Poole S, Harris M. Immunocytochemical localization of inflammatory cytokines and vascular adhesion receptors in radicular cysts. J Oral Pathol Med, 1993, 22(5):221-227. https:\/\/doi.org\/10.1111\/j.1600-0714.1993.tb01060.x","DOI":"10.1111\/j.1600-0714.1993.tb01060.x"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"[23] Meghji S, Qureshi W, Henderson B, Harris M. The role of endotoxin and cytokines in the pathogenesis of odontogenic cysts. Arch Oral Biol, 1996, 41(6):523-531. https:\/\/doi.org\/10.1016\/0003-9969(96)00032-5","DOI":"10.1016\/0003-9969(96)00032-5"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"[24] Jurisic V, Terzic T, Colic S, Jurisic M. The concentration of TNF-\u03b1 correlate with number of inflammatory cells and degree of vascularization in radicular cysts. Oral Dis, 2008, 14(7):600-605. https:\/\/doi.org\/10.1111\/j.1601-0825.2007.01426.x","DOI":"10.1111\/j.1601-0825.2007.01426.x"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"[25] Costa Neto H, de Andrade AL, Gord\u00f3n-N\u00fa\u00f1ez MA, Freitas RA, Galv\u00e3o HC. Immunoexpression of tryptase-positive mast cells in periapical granulomas and radicular cysts. Int Endod J, 2015, 48(8):729-735. https:\/\/doi.org\/10.1111\/iej.12366","DOI":"10.1111\/iej.12366"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"[26] de Noronha Santos Netto J, Pires FR, da Fonseca EC, Silva LE, de Queiroz Chaves Louren\u00e7o S. Evaluation of mast cells in periapical cysts, dentigerous cysts, and keratocystic odontogenic tumors. J Oral Pathol Med, 2012, 41(8):630-636. https:\/\/doi.org\/10.1111\/j.1600-0714.2012.01126.x","DOI":"10.1111\/j.1600-0714.2012.01126.x"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"[27] Kouhsoltani M, Moradzadeh Khiavi M, Jamali G, Farnia S. Immunohistochemical assessment of mast cells and small blood vessels in dentigerous cyst, odontogenic keratocyst, and periapical cyst. Adv Pharm Bull, 2015, 5(Suppl 1):637-641. https:\/\/doi.org\/10.15171\/apb.2015.086","DOI":"10.15171\/apb.2015.086"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"[28] Drazi\u0107 R, Sopta J, Mini\u0107 AJ. Mast cells in periapical lesions: potential role in their pathogenesis. J Oral Pathol Med, 2010, 39(3):257-262. https:\/\/doi.org\/10.1111\/j.1600-0714.2009.00870.x","DOI":"10.1111\/j.1600-0714.2009.00870.x"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"[29] Ramachandran Nair PN, Pajarola G, Schroeder HE. Types and incidence of human periapical lesions obtained with extracted teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1996, 81(1):93-102. https:\/\/doi.org\/10.1016\/s1079-2104(96)80156-9","DOI":"10.1016\/S1079-2104(96)80156-9"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"[30] Ricucci D, R\u00f4\u00e7as IN, Hern\u00e1ndez S, Siqueira JF Jr. \"True\" versus \"bay\" apical cysts: clinical, radiographic, histopathologic, and histobacteriologic features. J Endod, 2020, 46(9):1217-1227. https:\/\/doi.org\/10.1016\/j.joen.2020.05.025","DOI":"10.1016\/j.joen.2020.05.025"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"[31] Lima SCA, Rizo VHT, Silva-Sousa YTC, Almeida LY, Almeida OP, Le\u00f3n JE. Immunohistochemical evaluation of angiogenesis and tryptase-positive mast cell infiltration in periapical lesions. J Endod, 2011, 37(12):1642-1646. https:\/\/doi.org\/10.1016\/j.joen.2011.08.024","DOI":"10.1016\/j.joen.2011.08.024"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"[32] Fonseca-Silva T, Santos CCO, Alves LR, Dias LC, Brito M Jr, De Paula AMB, Guimar\u00e3es ALS. Detection and quantification of mast cell, vascular endothelial growth factor, and microvessel density in human inflammatory periapical cysts and granulomas. Int Endod J, 2012, 45(9):859-864. https:\/\/doi.org\/10.1111\/j.1365-2591.2012.02043.x","DOI":"10.1111\/j.1365-2591.2012.02043.x"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"[33] Lopes CB, Armada L, Pires FR. Comparative expression of CD34, intercellular adhesion molecule-1, and podoplanin and the presence of mast cells in periapical granulomas, cysts, and residual cysts. J Endod, 2018, 44(7):1105-1109. https:\/\/doi.org\/10.1016\/j.joen.2018.04.013","DOI":"10.1016\/j.joen.2018.04.013"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"[34] Khot K, Deshmukh SB, Alex S. Comparative analysis of the immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in keratocystic odontogenic tumor, dentigerous cyst and radicular cyst. J Cancer Res Ther, 2015, 11(3):635-640. https:\/\/doi.org\/10.4103\/0973-1482.144591","DOI":"10.4103\/0973-1482.144591"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"[35] de Moraes M, de Matos FR, de Souza LB, de Almeida Freitas R, de Lisboa Lopes Costa A. Immunoexpression of RANK, RANKL, OPG, VEGF, and vWF in radicular and dentigerous cysts. J Oral Pathol Med, 2013, 42(6):468-473. https:\/\/doi.org\/10.1111\/jop.12036","DOI":"10.1111\/jop.12036"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"[36] da Costa NMM, de Siqueira AS, Ribeiro ALR, da Silva Kataoka MS, Jaeger RG, de Alves-J\u00fanior SM, Smith AM, de Jesus Viana Pinheiro J. Role of HIF-1\u03b1 and CASPASE-3 in cystogenesis of odontogenic cysts and tumors. Clin Oral Investig, 2018, 22(1):141-149. https:\/\/doi.org\/10.1007\/s00784-017-2090-6","DOI":"10.1007\/s00784-017-2090-6"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"[37] Ege B, Bozgeyik E, Bayaz\u0131t S, Bozgeyik I, Erdogmus Z, Koparal M. Expression pattern of hypoxia-related genes in odontogenic cysts. Arch Oral Biol, 2023, 148:105639. https:\/\/doi.org\/10.1016\/j.archoralbio.2023.105639","DOI":"10.1016\/j.archoralbio.2023.105639"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"[38] Alsaegh MA, Shetty SR, Mahmoud O, Varma SR, Altaie AM, Rawat SS. The expression of HIF-1\u03b1 and VEGF in radicular cysts and periapical granulomas. Eur J Dent, 2025, 19(2):531-539. https:\/\/doi.org\/10.1055\/s-0044-1795078","DOI":"10.1055\/s-0044-1795078"},{"key":"ref38","unstructured":"[39] Graziani F, Vano M, Viacava P, Itro A, Tartaro G, Gabriele M. Microvessel density and vascular endothelial growth factor (VEGF) expression in human radicular cysts. Am J Dent, 2006, 19(1):11-14."},{"key":"ref39","unstructured":"[40] Ciolofan MS, Ioni\u0163\u0103 E, Ioni\u0163\u0103 I, Mogoant\u0103 CA, Anghelina F, Enescu A\u015e, Ciob\u00eerc\u0103 DM, Osman A, Foarf\u0103 MC, Mateescu GO. Chondrosarcoma of the hyoid bone: a case report. Rom J Morphol Embryol, 2015, 56(2 Suppl):811-816."},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"[41] Ciolofan MS, Mogoant\u0103 CA, Ioni\u0163\u0103 I, Mitroi MR, Mitroi GF, Anghelina F, Vl\u0103escu AN, C\u0103pit\u0103nescu AN, V\u00eelcea AM, Mitroi GG, Ic\u0103 OM, Stoica LE. Cutaneous malignant melanoma metastatic to the larynx and trachea: a case report and review of the literature. Life (Basel), 2023, 13(7):1452. https:\/\/doi.org\/10.3390\/life13071452","DOI":"10.3390\/life13071452"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"[42] Enache I, Ioni\u0163\u0103 E, Anghelina F, Mogoant\u0103 CA, Ciolofan MS, C\u0103pit\u0103nescu AN, V\u00eelcea AM, Florescu AM, Simionescu CE. Involvement of inflammatory cells in chronic rhinosinusitis with nasal polyps. Rom J Morphol Embryol, 2020, 61(3):871-877. https:\/\/doi.org\/10.47162\/RJME.61.3.25","DOI":"10.47162\/RJME.61.3.25"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"[43] Mogoant\u0103 CA, Ciolofan MS, Istrate-Ofi\u0163eru AM, Mogoant\u0103 S\u015e, Ro\u015fu GC, Anghelina F, C\u0103pitanescu AN, Opriscan IC, Ionovici N, Mitroi MR, Badea O, Iov\u0103nescu G. HPV and other risk factors involved in pharyngeal neoplasm - clinical and morphopathological correlations in the Southwestern region of Romania. Pathogens, 2023, 12(8):984. https:\/\/doi.org\/10.3390\/pathogens12080984\"","DOI":"10.3390\/pathogens12080984"}],"container-title":["Romanian Journal of Morphology and Embryology"],"original-title":[],"link":[{"URL":"https:\/\/rjme.ro\/RJME\/resources\/files\/670126097106.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:00:16Z","timestamp":1784329216000},"score":1,"resource":{"primary":{"URL":"https:\/\/rjme.ro\/archive\/67\/1\/10\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,7,12]]},"published-print":{"date-parts":[[2026,7,12]]}},"URL":"https:\/\/doi.org\/10.47162\/rjme.67.1.10","relation":{},"ISSN":["1220-0522","2066-8279"],"issn-type":[{"value":"1220-0522","type":"print"},{"value":"2066-8279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]}}}