{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:04:30Z","timestamp":1784329470464,"version":"3.55.0"},"reference-count":52,"publisher":"Societatea Romana de Morfologie","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2026,7,10]]},"abstract":"<jats:p>Background: Ileal neuroendocrine tumors (NETs) are well-differentiated neoplasms with relatively indolent histological features but an often aggressive biological behavior, characterized by early lymphatic and hematogenous dissemination. Increasing evidence suggests that systemic inflammatory and nutritional status may influence tumor progression; however, data regarding these parameters in ileal NETs remain limited. Patients, Materials and Methods: A retrospective observational study was conducted on 12 consecutive patients with histologically confirmed ileal NETs who underwent surgical treatment between 2018 and 2024. Clinicopathological, morphological, immunohistochemical, and laboratory data were analyzed. Systemic inflammatory and nutritional indices, including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, lymphocyte-to-monocyte ratio, and prognostic nutritional index, were calculated from preoperative blood tests and evaluated in relation to metastatic status. Results: The cohort comprised predominantly well-differentiated NETs classified as NET G1\u2013G2. Most tumors showed deep wall infiltration and a high prevalence of regional lymph node and distant metastases at diagnosis. Patients with metastatic disease were significantly younger and had lower hemoglobin levels. Higher values of inflammatory indices and lower nutritional markers were consistently observed in the metastatic group, although these differences did not reach statistical significance. Conclusions: Ileal NETs exhibit a distinct biological behavior in which well-differentiated morphology frequently coexists with advanced disease. Systemic inflammatory and nutritional indices may reflect tumor burden and metastatic potential and could complement histopathological evaluation in the clinical assessment of ileal NETs. Larger prospective studies are warranted to clarify their prognostic value.<\/jats:p>","DOI":"10.47162\/rjme.67.1.11","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:55:06Z","timestamp":1784328906000},"page":"107-115","source":"Crossref","is-referenced-by-count":0,"title":["Ileal neuroendocrine tumors: clinicopathological features and associations with systemic inflammatory and nutritional markers"],"prefix":"10.47162","volume":"67","author":[{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Emergency County Hospital, Craiova, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolae Drago\u015f","family":"M\u0103rg\u0103ritescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiberiu \u015etef\u0103ni\u0163\u0103","family":"\u0162enea-Cojan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Railway Clinical Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Florin R\u0103zvan","family":"Mogo\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Railway Clinical Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelian \u015etef\u0103ni\u0163\u0103","family":"Mogoant\u0103","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Emergency County Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liviu","family":"Vasile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Emergency County Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Cercelaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Anatomy and Embryology, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren\u0163iu Augustus","family":"Barbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of Surgery, Railway Clinical Hospital, Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26736","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Gopakumar H, Jahagirdar V, Koyi J, Dahiya DS, Goyal H, Sharma NR, Perisetti A. Role of advanced gastrointestinal endoscopy in the comprehensive management of neuroendocrine neoplasms. Cancers (Basel), 2023, 15(16):4175. https:\/\/doi.org\/10.3390\/cancers15164175","DOI":"10.3390\/cancers15164175"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"[2] Yoon JY, Kumta NA, Kim MK. The role of endoscopy in small bowel neuroendocrine tumors. Clin Endosc, 2021, 54(6):818-824. https:\/\/doi.org\/10.5946\/ce.2020.296 PMID: 33794563","DOI":"10.5946\/ce.2020.296"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"[3] Niederle B, Selberherr A, Niederle MB. How to manage small intestine (jejunal and ileal) neuroendocrine neoplasms presenting with liver metastases? Curr Oncol Rep, 2021, 23(7):85. https:\/\/doi.org\/10.1007\/s11912-021-01074-2","DOI":"10.1007\/s11912-021-01074-2"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"[4] Kmiotek E, Lakda S, Borakati A, Ogunbiyi O, Mandair D, Caplin M, Toumpanakis C, Mirnezami R. Management strategies and outcomes for small intestinal neuroendocrine tumours with involvement of the superior mesenteric vessels: a systematic review. Curr Oncol, 2023, 30(10):9192-9204. https:\/\/doi.org\/10.3390\/curroncol30100664","DOI":"10.3390\/curroncol30100664"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"[5] Kenney LM, Hughes M. Surgical management of gastroenteropancreatic neuroendocrine tumors. Cancers (Basel), 2025, 17(3):377. https:\/\/doi.org\/10.3390\/cancers17030377","DOI":"10.3390\/cancers17030377"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"[6] Kiesewetter-Wiederkehr B, Melhorn P, Scheuba C, Raderer M. Aktuelle Entwicklungen in der Behandlung neuroendokriner Tumoren [Current developments in the treatment of neuroendocrine tumors]. Radiologie (Heidelb), 2024, 64(7):568-574. https:\/\/doi.org\/10.1007\/s00117-024-01303-2","DOI":"10.1007\/s00117-024-01303-2"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"[7] Selberherr A, Niederle MB, Niederle B. Surgical treatment of small intestinal neuroendocrine tumors G1\/G2. Visc Med, 2017, 33(5):340-343. https:\/\/doi.org\/10.1159\/000477786","DOI":"10.1159\/000477786"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"[8] Kupietzky A, Dover R, Mazeh H. Surgical aspects of small intestinal neuroendocrine tumors. World J Gastrointest Surg, 2023, 15(4):566-577. https:\/\/doi.org\/10.4240\/wjgs.v15.i4.566","DOI":"10.4240\/wjgs.v15.i4.566"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"[9] M\u00f6ller K, Jenssen C, Dirks K, Hollerweger A, Gottschall H, Faiss S, Dietrich CF. Small intestine tumors: diagnostic role of multiparametric ultrasound. Healthcare (Basel), 2025, 13(21):2776. https:\/\/doi.org\/10.3390\/healthcare13212776","DOI":"10.3390\/healthcare13212776"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"[10] Howe JR, Cardona K, Fraker DL, Kebebew E, Untch BR, Wang YZ, Law CH, Liu EH, Kim MK, Menda Y, Morse BG, Bergsland EK, Strosberg JR, Nakakura EK, Pommier RF. The surgical management of small bowel neuroendocrine tumors: Consensus Guidelines of the North American Neuroendocrine Tumor Society. Pancreas, 2017, 46(6):715-731. https:\/\/doi.org\/10.1097\/mpa.0000000000000846","DOI":"10.1097\/MPA.0000000000000846"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"[11] Clift AK, Drymousis P, von Roon A, Humphries A, Goldin R, Bomanji J, Leaman S, Wasan H, Habib N, Frilling A. Management of small bowel neuroendocrine tumours: 10 years' experience at a tertiary referral centre. Cancers (Basel), 2023, 15(18):4438. https:\/\/doi.org\/10.3390\/cancers15184438","DOI":"10.3390\/cancers15184438"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"[12] Wu P, He D, Chang H, Zhang X. Epidemiologic trends of and factors associated with overall survival in patients with neuroendocrine tumors over the last two decades in the USA. Endocr Connect, 2023, 12(12):e230331. https:\/\/doi.org\/10.1530\/EC-23-0331","DOI":"10.1530\/EC-23-0331"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"[13] Yu Q, Cao F, Hosein P, Huang B, Pinheiro PS, Wang Y, Del Rivero J, Lopes G, Chauhan A. Dethroning of neuroendocrine tumor as an orphan disease: US incidence, prevalence, and survival in the 21st century. Cancers (Basel), 2025, 17(20):3323. https:\/\/doi.org\/10.3390\/cancers17203323","DOI":"10.3390\/cancers17203323"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"[14] Mangion J, Vassallo J, Gruppetta M. Epidemiological insights and survival patterns in neuroendocrine neoplasia: a geographic perspective. Endocr Oncol, 2025, 5(1):e250039. https:\/\/doi.org\/10.1530\/EO-25-0039","DOI":"10.1530\/EO-25-0039"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"[15] Darb\u00e0 J, Mars\u00e0 A. Exploring the current status of neuroendocrine tumours: a population-based analysis of epidemiology, management and use of resources. BMC Cancer, 2019, 19(1):1226. https:\/\/doi.org\/10.1186\/s12885-019-6412-8","DOI":"10.1186\/s12885-019-6412-8"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"[16] Bla\u017eevi\u0107 A, Iyer AM, van Velthuysen MLF, Hofland J, Oudijk L, de Herder WW, Hofland LJ, Feelders RA. Sexual dimorphism in small-intestinal neuroendocrine tumors: lower prevalence of mesenteric disease in premenopausal women. J Clin Endocrinol Metab, 2022, 107(5):e1969-e1975. https:\/\/doi.org\/10.1210\/clinem\/dgac001","DOI":"10.1210\/clinem\/dgac001"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"[17] Musters GD, Atema JJ, van Westreenen HL, Buskens CJ, Bemelman WA, Tanis PJ. Ileostomy closure by colorectal surgeons results in less major morbidity: results from an institutional change in practice and awareness. Int J Colorectal Dis, 2016, 31(3):661-667. https:\/\/doi.org\/10.1007\/s00384-015-2478-1","DOI":"10.1007\/s00384-015-2478-1"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"[18] Lee S, Jyala A, Ghazanfar H, Shin D, Patel H. Diagnostic challenge of small bowel neuroendocrine tumor in a young female patient. Cureus, 2023, 15(4):e37925. https:\/\/doi.org\/10.7759\/cureus.37925","DOI":"10.7759\/cureus.37925"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"[19] Juhlin CC, Bal M. Top 10 histological mimics of neuroendocrine carcinoma you should not miss in the head and neck. Head Neck Pathol, 2023, 17(1):66-84. https:\/\/doi.org\/10.1007\/s12105-022-01521-x","DOI":"10.1007\/s12105-022-01521-x"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"[20] Ozsen M, Senol K, Tolunay S, Gokgoz MS, Evrensel T. Histopathological features predicting neuroendocrine morphology in primary breast tumors: a retrospective analysis. Eur J Breast Health, 2024, 20(2):110-116. https:\/\/doi.org\/10.4274\/ejbh.galenos.2024.2023-12-10","DOI":"10.4274\/ejbh.galenos.2024.2023-12-10"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"[21] Tang LH, Untch BR, Reidy DL, O'Reilly E, Dhall D, Jih L, Basturk O, Allen PJ, Klimstra DS. Well-differentiated neuro-endocrine tumors with a morphologically apparent high-grade component: a pathway distinct from poorly differentiated neuroendocrine carcinomas. Clin Cancer Res, 2016, 22(4):1011-1017. https:\/\/doi.org\/10.1158\/1078-0432.CCR-15-0548. Erratum in: Clin Cancer Res, 2016, 22(16):4273. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-1342","DOI":"10.1158\/1078-0432.CCR-16-1342"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"[22] Ranot JM, Hamid JS, Montazeri A, Harper K, McCudden C, Moyana TN. Well-differentiated jejunoileal neuroendocrine tumors and corresponding liver metastases: mesenteric fibrogenesis and extramural vascular invasion in tumor progression. Cancers (Basel), 2025, 17(9):1486. https:\/\/doi.org\/10.3390\/cancers17091486","DOI":"10.3390\/cancers17091486"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"[23] Puccini A, Battaglin F, Lenz HJ. Management of advanced small bowel cancer. Curr Treat Options Oncol, 2018, 19(12):69. https:\/\/doi.org\/10.1007\/s11864-018-0592-3","DOI":"10.1007\/s11864-018-0592-3"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"[24] Barbu LA, Vasile L, Cercelaru L, \u015eurlin V, Mogoant\u0103 S\u015e, Mogo\u015f GFR, \u0162enea Cojan TS, M\u0103rg\u0103ritescu ND, Iordache MP, Buliman A. Aggressiveness in well-differentiated small intestinal neuroendocrine tumors: a rare case and narrative literature review. J Clin Med, 2025, 14(16):5821. https:\/\/doi.org\/10.3390\/jcm14165821","DOI":"10.3390\/jcm14165821"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"[25] Ratnayake GM, Laskaratos FM, Mandair D, Caplin ME, Rombouts K, Toumpanakis C. What causes desmoplastic reaction in small intestinal neuroendocrine neoplasms? Curr Oncol Rep, 2022, 24(10):1281-1286. https:\/\/doi.org\/10.1007\/s11912-022-01211-5","DOI":"10.1007\/s11912-022-01211-5"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"[26] Pelle E, Al-Toubah T, Morse B, El-Haddad G, Strosberg J. Desmoplastic mesenteric lesions do not respond radiographically to peptide receptor radionuclide therapy. J Neuroendocrinol, 2021, 33(2):e12936. https:\/\/doi.org\/10.1111\/jne.12936","DOI":"10.1111\/jne.12936"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"[27] Gelsomino F, Balsano R, De Lorenzo S, Garajov\u00e1 I. Small bowel adenocarcinoma: from molecular insights to clinical management. Curr Oncol, 2022, 29(2):1223-1236. https:\/\/doi.org\/10.3390\/curroncol29020104","DOI":"10.3390\/curroncol29020104"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"[28] Barbu LA, Cercelaru L, \u015eurlin V, Mogoant\u0103 SS, \u0162enea Cojan TS, M\u0103rg\u0103ritescu ND, \u0162enea Cojan AM, C\u0103luianu V, Mogo\u015f GFR, Vasile L. Colorectal cancer in Romania: surgical strategies, survival, and historical trends in a 302-patient cohort. Life (Basel), 2025, 15(11):1686. https:\/\/doi.org\/10.3390\/life15111686","DOI":"10.3390\/life15111686"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"[29] Ji H, Hu C, Yang X, Liu Y, Ji G, Ge S, Wang X, Wang M. Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions. Signal Transduct Target Ther, 2023, 8(1):367. https:\/\/doi.org\/10.1038\/s41392-023-01576-4","DOI":"10.1038\/s41392-023-01576-4"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"[30] Reticker-Flynn NE, Engleman EG. Lymph nodes: at the intersection of cancer treatment and progression. Trends Cell Biol, 2023, 33(12):1021-1034. https:\/\/doi.org\/10.1016\/j.tcb.2023.04.001","DOI":"10.1016\/j.tcb.2023.04.001"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"[31] Gheorghi\u015fan-G\u0103l\u0103\u0163eanu AA, Ilie\u015fiu A, Lambrescu IM, \u0162\u0103poi DA. The complex histopathological and immunohistochemical spectrum of neuroendocrine tumors - an overview of the latest classifications. Int J Mol Sci, 2023, 24(2):1418. https:\/\/doi.org\/10.3390\/ijms24021418","DOI":"10.3390\/ijms24021418"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"[32] Uhlig R, Dum D, Gorbokon N, Menz A, B\u00fcscheck F, Luebke AM, Hube-Magg C, Hinsch A, H\u00f6flmayer D, Fraune C, M\u00f6ller K, Bernreuther C, Lebok P, Weidemann S, Lennartz M, Jacobsen F, Clauditz TS, Sauter G, Wilczak W, Steurer S, Burandt E, Krech R, Krech T, Marx AH, Simon R, Minner S. Synaptophysin and chromogranin A expression analysis in human tumors. Mol Cell Endocrinol, 2022, 555:111726. https:\/\/doi.org\/10.1016\/j.mce.2022.111726","DOI":"10.1016\/j.mce.2022.111726"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"[33] Ka\u00e7maz E, Chen JW, Tanis PJ, Nieveen van Dijkum EJM, Engelsman AF. Postoperative morbidity and mortality after surgical resection of small bowel neuroendocrine neoplasms: a systematic review and meta-analysis. J Neuroendocrinol, 2021, 33(8):e13008. https:\/\/doi.org\/10.1111\/jne.13008","DOI":"10.1111\/jne.13008"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"[34] Park S, Parihar AS, Bodei L, Hope TA, Mallak N, Millo C, Prasad K, Wilson D, Zukotynski K, Mittra E. Somatostatin receptor imaging and theranostics: current practice and future prospects. J Nucl Med, 2021, 62(10):1323-1329. https:\/\/doi.org\/10.2967\/jnumed.120.251512","DOI":"10.2967\/jnumed.120.251512"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"[35] Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, \u00d6berg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Ta\u00efeb D, Virgolini I, Wild D, Herrmann K, Yao J. Consensus on molecular imaging and theranostics in neuroendocrine neoplasms. Eur J Cancer, 2021, 146:56-73. https:\/\/doi.org\/10.1016\/j.ejca.2021.01.008","DOI":"10.1016\/j.ejca.2021.01.008"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"[36] Barbu LA, Cercelaru L, \u015eurlin V, Mogoant\u0103 SS, \u0162enea Cojan TS, Marinescu D, M\u0103rg\u0103ritescu ND, Vasile L. Ki-67 and tumor size in small bowel tumors: findings from an exploratory immuno-histochemical analysis. Life (Basel), 2025, 15(12):1894. https:\/\/doi.org\/10.3390\/life15121894","DOI":"10.3390\/life15121894"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"[37] Checchin F, Malerba D, Gambella A, Puleri AR, Sambuceti V, Vanoli A, Grillo F, Preda L, Bortolotto C. Radiomic analysis for Ki-67 classification in small bowel neuroendocrine tumors. Cancers (Basel), 2026, 18(3):463. https:\/\/doi.org\/10.3390\/cancers18030463","DOI":"10.3390\/cancers18030463"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"[38] Tian J, Chen W. Prediction of Ki-67 expression and malignant potential in gastrointestinal stromal tumors: novel models based on CE-CT and serological indicators. BMC Cancer, 2024, 24(1):1412. https:\/\/doi.org\/10.1186\/s12885-024-13172-y","DOI":"10.1186\/s12885-024-13172-y"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"[39] Barbu LA, Cercelaru L, V\u00eelcea ID, \u015eurlin V, Mogoant\u0103 SS, \u0162enea Cojan TS, M\u0103rg\u0103ritescu ND, \u0162enea Cojan AM, C\u0103luianu V, Popescu M, Mogo\u015f GFR, Vasile L. Enteroenteric fistula following multiple magnet ingestion in an adult: case report, literature review and management algorithm. Healthcare (Basel), 2025, 13(19):2523. https:\/\/doi.org\/10.3390\/healthcare13192523","DOI":"10.3390\/healthcare13192523"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"[40] Wacka E, Nicikowski J, Jarmuzek P, Zembron-Lacny A. Anemia and its connections to inflammation in older adults: a review. J Clin Med, 2024, 13(7):2049. https:\/\/doi.org\/10.3390\/jcm13072049","DOI":"10.3390\/jcm13072049"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"[41] Liu J, Li S, Zhang S, Liu Y, Ma L, Zhu J, Xin Y, Wang Y, Yang C, Cheng Y. Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio can predict clinical outcomes in patients with metastatic non-small-cell lung cancer treated with Nivolumab. J Clin Lab Anal, 2019, 33(8):e22964. https:\/\/doi.org\/10.1002\/jcla.22964","DOI":"10.1002\/jcla.22964"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"[42] Keskinkilic M, Semiz HS, Ataca E, Yavuzsen T. The prognostic value of immune-nutritional status in metastatic colorectal cancer: prognostic nutritional index (PNI). Support Care Cancer, 2024, 32(6):374. https:\/\/doi.org\/10.1007\/s00520-024-08572-6","DOI":"10.1007\/s00520-024-08572-6"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"[43] M\u0103rg\u0103ritescu ND, Marinescu D, \u0162enea-Cojan T\u015e, Vasile L, Cercelaru L, Mogo\u015f GFR, Mogoant\u0103 S\u015e, Barbu LA. Small bowel GISTs: clinicopathological patterns and the role of inflammatory markers. Rom J Morphol Embryol, 2025, 66(3):571-580. https:\/\/doi.org\/10.47162\/RJME.66.3.14","DOI":"10.47162\/RJME.66.3.14"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"[44] \u0162enea Cojan TS, \u015eurlin V, Mogoant\u0103 SS, M\u0103rg\u0103ritescu ND, Caragea DC, \u0162enea Cojan IA, C\u0103luianu V, Marina\u015f MC, Mogo\u015f GFR, Vasile L, Barbu LA. Synchronous ileal metastasis from pancreatic ductal adenocarcinoma: case report and narrative review with practical diagnostic and management points. Life (Basel), 2025, 15(11):1684. https:\/\/doi.org\/10.3390\/life15111684","DOI":"10.3390\/life15111684"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"[45] Cioboata R, Nicolosu D, Balasoiu AT, Balteanu MA, Zlatian OM, Osman A, Biciusca V, Tieranu EN, Mogos GFR, Ghenea AE. Vitamin C and tuberculosis: examining the relationship between antioxidant defense and disease severity - preliminary findings from a southwestern Romanian study. J Clin Med, 2024, 13(22):6715. https:\/\/doi.org\/10.3390\/jcm13226715","DOI":"10.3390\/jcm13226715"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"[46] Mitroi DM, Balteanu MA, Cioboata R, Vlasceanu SG, Zlatian OM, Catana OM, Mirea AA, Mogos GFR, Rotaru I, Biciusca V. Hypercoagulability in tuberculosis: pathophysiological mechanisms, associated risks, and advances in management - a narrative review. J Clin Med, 2025, 14(3):762. https:\/\/doi.org\/10.3390\/jcm14030762","DOI":"10.3390\/jcm14030762"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"[47] Mogo\u015f GFR, Manciulea Profir M, Enache RM, Pavelescu LA, Popescu Ro\u015fu OA, Cretoiu SM, Marinescu I. Intestinal microbiota in early life: latest findings regarding the role of probiotics as a treatment approach for dysbiosis. Nutrients, 2025, 17(13):2071. https:\/\/doi.org\/10.3390\/nu17132071","DOI":"10.3390\/nu17132071"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"[48] Gaitanidis A, Patel D, Nilubol N, Tirosh A, Sadowski S, Kebebew E. Markers of systemic inflammatory response are prognostic factors in patients with pancreatic neuroendocrine tumors (PNETs): a prospective analysis. Ann Surg Oncol, 2018, 25(1):122-130. https:\/\/doi.org\/10.1245\/s10434-017-6241-4","DOI":"10.1245\/s10434-017-6241-4"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"[49] He B, He Q, Lai Z, Niu Z, Zhang J, Wang Y. The value of systemic inflammatory index and nutritional marker in predicting acute calculus cholecystitis and its severity. J Inflamm Res, 2025, 18:9505-9521. https:\/\/doi.org\/10.2147\/JIR.S521080","DOI":"10.2147\/JIR.S521080"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"[50] Marinescu I, Marinescu D, Mogoant\u0103 L, Efrem IC, Stovicek PO. SARS-CoV-2 infection in patients with serious mental illness and possible benefits of prophylaxis with Memantine and Amantadine. Rom J Morphol Embryol, 2020, 61(4):1007-1022. https:\/\/doi.org\/10.47162\/RJME.61.4.03","DOI":"10.47162\/RJME.61.4.03"},{"key":"ref50","unstructured":"[51] Bondoc EN, Marinescu D, Marinescu I, M\u0103lin RD, Stanca L, Z\u0103voi RE. Current understanding of psycho-neurobiology in depressive disorders with suicidal thoughts - translational models. Rom J Morphol Embryol, 2019, 60(2):389-402."},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"[52] En\u0103tescu VR, Kalinovi\u0107 R, Vlad G, Nussbaum LA, Hogea L, En\u0103tescu I, Marinescu I, Ifteni P, Simu M, Marian C, Giurgi-Oncu C, Papav\u0103 I. The presence of peripheral inflammatory markers in patients with major depressive disorder, the associated symptoms profiles and the antidepressant efficacy of Celecoxib. Farmacia, 2020, 68(3):483-491. https:\/\/doi.org\/10.31925\/farmacia.2020.3.14\"","DOI":"10.31925\/farmacia.2020.3.14"}],"container-title":["Romanian Journal of Morphology and Embryology"],"original-title":[],"link":[{"URL":"https:\/\/rjme.ro\/RJME\/resources\/files\/670126107115.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:00:38Z","timestamp":1784329238000},"score":1,"resource":{"primary":{"URL":"https:\/\/rjme.ro\/archive\/67\/1\/11\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,7,12]]},"published-print":{"date-parts":[[2026,7,12]]}},"URL":"https:\/\/doi.org\/10.47162\/rjme.67.1.11","relation":{},"ISSN":["1220-0522","2066-8279"],"issn-type":[{"value":"1220-0522","type":"print"},{"value":"2066-8279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]}}}