{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:04:35Z","timestamp":1784329475632,"version":"3.55.0"},"reference-count":46,"publisher":"Societatea Romana de Morfologie","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rom J Morphol Embryol"],"published-print":{"date-parts":[[2026,7,10]]},"abstract":"<jats:p>Introduction: Adrenal tumors involve multidisciplinary challenges, including bone health impairment due to mild or fully manifested cortisol overproduction by the adrenal cortex. Aim: We aimed to assess dual-energy X-ray absorptiometry (DXA)-based category switch in non-surgery candidates who were initially diagnosed with non-functional adrenal tumors (NFATs) at computed tomography (CT). Patients, Materials and Methods: This was real-life setting associated with a longitudinal analysis in menopausal individuals (age range: 50 to 80 years) diagnosed with NFATs who had a central DXA scan at baseline and during monitorization. Exclusion criteria: malignancies, functional adrenal tumors. Results: The initial cohort (N=33) included: 21.21% of the patients had osteoporosis (group A), 60.61% had osteopenia (group B) and 18.18% had normal DXA (group C), with similar age and menopause duration, but higher body mass index (BMI) in group C vs. group A (35.33\u00b18.61 vs. 26.82\u00b14.00 kg\/m2; p=0.039). Hormonal and CT-based features were similar among the groups. Group C had higher osteocalcin vs. group B (30.93\u00b114.07 vs. 18.88\u00b18.42; p=0.051). Baseline morning (plasma) cortisol negatively correlated with DXA\u2013bone mineral density (BMD) at femoral neck (r=-0.539, p=0.017). Median follow-up was similar among the groups (50 months, Q1\u2013Q3 quartiles: 24 to 71 months). 66.67% of patients from group C experienced a DXA category switch vs. group B (20.00%; p=0.051). Decrease DXA category switch was more prevalent in group C vs. group A (p=0.021), respectively, group C vs. group B (p=0.013). Conclusions: Sharpest DXA\u2013BMD decline was between 48 and 72 months. The cumulative probabilities of decrease DXA category switch-free survival were higher in osteopenia vs. normal (p-value log-rank: 0.026), indicating that patients with normal results of DXA\u2013BMD were more likely to decrease category in comparison to the subjects initially confirmed with osteopenia. To our best knowledge, only a limited number of studies longitudinally assessed bone status in NFATs so far.<\/jats:p>","DOI":"10.47162\/rjme.67.1.15","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:55:06Z","timestamp":1784328906000},"page":"147-156","source":"Crossref","is-referenced-by-count":0,"title":["A longitudinal study of dual-energy X-ray absorptiometry status in menopausal women with adrenal tumors"],"prefix":"10.47162","volume":"67","author":[{"name":"Doctoral School, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Department of Clinical Endocrinology V, C.I. Parhon National Institute of Endocrinology, Bucharest, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra-Ioana","family":"Trandafir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Ionovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Occupational Medicine, University of Medicine and Pharmacy of Craiova, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana Cristina","family":"Terzea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pathology, C.I. Parhon National Institute of Endocrinology, Bucharest, Romania; Oncoteam Diagnostics, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana-Claudia","family":"Sima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Clinical Endocrinology V, C.I. Parhon National Institute of Endocrinology, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Costachescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Radiology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Carsote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Doctoral School, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Department of Clinical Endocrinology V, C.I. Parhon National Institute of Endocrinology, Bucharest, Romania; Department of Endocrinology, Carol Davila University of Med","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26736","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Magouri O, Bentebbaa FZ, Boutaybi L, Bouichrat N, Rouf S, Latrech H. Adrenal incidentalomas: clinical, biological, imaging and therapeutic features. Med Pharm Rep, 2025, 98(4):468-474. https:\/\/doi.org\/10.15386\/mpr-2862","DOI":"10.15386\/mpr-2862"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"[2] Yener S, Tuna G, Sahin H, Adiyaman SC, Saydam BO, Baris M, Islekel GH. Estimation of cortisol exposure in patients with adrenal incidentalomas. 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