{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T09:13:18Z","timestamp":1753521198277},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"10 (Supple-08)","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Aim: To assess the role of serum micro ribonucleic acids 323-3p, 517a and 519d in the diagnosis of ectopic pregnancy.\r\nMethod: The case-control study was conducted at the Gynaecology Department of Al-Yarmouk Teaching Hospital, Baghdad, Iraq, from June 1, 2020, to May 1, 2021, and comprised women with ectopic pregnancy in group A, and those with a viable intrauterine pregnancy in group B. Serum samples were taken for beta human chorionic gonadotropin measurement and for micro ribonucleic acids 323-3p, 517a and 519d testing using polymerase chain reaction. Data was analysed using SPSS 24.\r\nResults: Of the 100 women with mean age 26.8\u00b15.29 years, 50(50%) were in each of the 2 groups. There was no significant difference between the groups in terms of age, gravida, parity, abortion, and gestational age (p&gt;0.05). The mean beta human chorionic gonadotropin in group B was significantly greater than group A (p=0.001). In group A, micro ribonucleic acid 323-3p expression was significantly higher, mean micro ribonucleic acid 517a expression was significantly lower and mean micro ribonucleic acid 519d expression was significantly lower compared to group B (p&lt;0.05). At micro ribonucleic acid 323-3p cut-off point 2.415, the test accurately distinguished between ectopic and viable pregnancy with 92% sensitivity, 100% specificity and total area under the curve 0.994 (p=0.001).\r\nConclusion: Serum micro ribonucleic acid 323-3p, 517a and 519d might be helpful biomarkers in the diagnosis and follow-up of patients with ectopic pregnancy.\r\nKey Words: Pregnancy, Gestational, Gynecology, Ectopic, Chorionic Gonadotropin, Polymerase Chain Reaction, MicroRNAs<\/jats:p>","DOI":"10.47391\/jpma-bagh-16-13","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T14:24:38Z","timestamp":1728397478000},"page":"S52-S55","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of serum level of MicroRNA323-3p, MicroRNA517a and MicroRNA519d in Ectopic pregnancy: a comparative study"],"prefix":"10.47391","volume":"74","author":[{"family":"Farah Ahmed Dera'a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Fadia Jassim Alizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2024,9,28]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/21790\/3620","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/21790\/3620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T14:25:35Z","timestamp":1728656735000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/21790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,28]]},"references-count":0,"journal-issue":{"issue":"10 (Supple-08)","published-online":{"date-parts":[[2024,9,28]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma-bagh-16-13","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"type":"electronic","value":"0030-9982"},{"type":"print","value":"0030-9982"}],"subject":[],"published":{"date-parts":[[2024,9,28]]}}}