{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:37:26Z","timestamp":1787031446858,"version":"build-2736575974"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"2","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To examine the therapeutic effects of Olea europaea L. leaves extract on carbon tetrachloride-induced liver injury in rats.\nMethod: The experimental study was conducted at the Department of Physiology, University of Karachi, Karachi, in July 2021, and comprised Albino Wistar male rats weighing 180-220gm. The animals were divided into control group I, carbon tetrachloride group II, Olea europaea L. + carbon tetrachloride group III and Olea europaea L. group IV. In Vitro model of hepatic toxicity was developed by carbon tetrachloride. A daily dose of 50mg\/kg of aqueous extract of olive leaves was administered orally and 0.8ml\/kg of carbon tetrachloride was administered twice a week subcutaneously for 28 days. On the 29th day, the animals were sacrificed, and tested for hepatic enzymes, lipid peroxidation markers and histopathology. Data was analysed using SPSS 20.\nResults: Of the 24 rats, 6(25%) were in each of the 4 groups. Alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin levels were significantly reduced (p&lt;0.05) in group II whereas, 4- hydroxynonenal, isoprostane and malondialdehyde levels were significantly increased (p&lt;0.05). However, total antioxidant level increased significantly (p&lt;0.05) in group III compared to group II. Histopathology showed severe liver damage in group II and mild damage in group III.\nConclusion: Olea europaea L. leaves extract was found to have profound hepatoprotective effects.\nKey Words: Antioxidants, Olea, carbon tetrachloride, alanine transaminase, alkaline phosphatase, liver injury, chronic, lipid peroxidation, bilirubin, aspartate aminotransferases, malondialdehyde, isoprostanes<\/jats:p>","DOI":"10.47391\/jpma-duhs-s13","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:34:00Z","timestamp":1707957240000},"page":"S63-S67","source":"Crossref","is-referenced-by-count":2,"title":["The hepatoprotective potentials of Olea europaea L. leaves against carbon tetrachloride-induced hepatic injury in rats"],"prefix":"10.47391","volume":"74","author":[{"family":"Amber Ayaz Memon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Lubna Naz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26547","published-online":{"date-parts":[[2024,2,11]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/download\/20251\/3071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/download\/20251\/3071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:34:00Z","timestamp":1707957240000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/20251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,11]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,14]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma-duhs-s13","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,11]]}}}