{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T20:13:35Z","timestamp":1648930415013},"reference-count":0,"publisher":"Pakistan Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Madam,&#x0D;\nThere is an increased prevalence of infertility in male population. With reference to a variety of mechanisms, oxidative stress (OS) is responsible for alteration in \u00a0structural and functional integrity of sperm leading to altered sperm parameters, hence leading to infertility (1).&#x0D;\nMetformin though proved to be a first-line hypoglycemic agent has demonstrated antioxidant properties in numerous tissues. It inhibits the mitochondrial respiratory chain in the liver, which leads to stimulation of AMP-activated protein kinase (AMPK)-dependent as well as AMPK-independent mechanisms (2). Metformin triggers alanine production within the Sertoli cells (SCs,) balances\u00a0 the NADH\/NAD+ equilibrium and provides antioxidant environment. This drug is a treatment of choice in treating females with Polycystic Ovaries (PCOS) on the basis of its capability to reduce insulin sensitivity as well as angiogenesis through the nuclear factor ?B (NF-?B) pathway which renders it to reduce oxidant species, thus improving the reproductive environment (3). Continuous....<\/jats:p>","DOI":"10.47391\/jpma.11-1318","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T13:11:36Z","timestamp":1611234696000},"page":"1-2","source":"Crossref","is-referenced-by-count":0,"title":["Metformin, Oxidative Stress and Male Infertility: Way Forward"],"prefix":"10.47391","author":[{"given":"Faiza","family":"Alam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Nida Farooqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Rehana Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2021,1,21]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"deposited":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T14:43:12Z","timestamp":1614696192000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/3142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.47391\/jpma.11-1318","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1,21]]}}}