{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T05:21:43Z","timestamp":1741238503562,"version":"3.38.0"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"03","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objectives: To determine the effectiveness of intrauterine misoprostol along with oxytocin versus oxytocin monotherapy for the prevention of primary postpartum haemorrhage.\nMethod: The quasi-randomised controlled trial took place at the Akbar Niazi Teaching Hospital, Islamabad, Pakistan, from February to August 2021, and comprised women who underwent lower segment caesarean section and at full-term pregnancy who had risk factors for experiencing postpartum haemorrhage. The subjects were randomised into experimental group A and control group B. Group A subjects received both misoprostol and oxytocin, while those in group B received oxytocin only. Data was analysed using SPSS 26.\nResults: Of the 120 subjects, 60(50%) were in group A with mean age 28.72\u00b15.82 years and mean gestational age 38.02\u00b11.1 weeks. The remaining 60(50%) subjects were in group B with mean age 29.47\u00b14.72 years and mean gestational age 37.50\u00b11.5 weeks. Group A subjects had fewer changes in haemoglobin levels post-operation than those in group B (p&lt;0.05). The number of operative towels used, contractility time of the uterus, and need for other drugs to control haemorrhage were significantly different in group A compared to group B.\nConclusion: Misoprostol along with oxytocin was found to be more effective in reducing blood loss in patients with postpartum haemorrhage.\nKey Words: Postpartum haemorrhage, Misoprostol, Oxytocin, Postoperative blood loss.<\/jats:p>","DOI":"10.47391\/jpma.11080","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T14:50:10Z","timestamp":1740495010000},"page":"405-408","source":"Crossref","is-referenced-by-count":0,"title":["A comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhage"],"prefix":"10.47391","volume":"75","author":[{"family":"Afnan Rizwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Hassaan","family":"Farooq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Uzma Nayyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Asma Irfan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mahwish Farooq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Maryam Siddique","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2025,2,23]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/11080\/3987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/11080\/3987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T14:58:39Z","timestamp":1741186719000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/11080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,23]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,2,25]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.11080","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"type":"electronic","value":"0030-9982"},{"type":"print","value":"0030-9982"}],"subject":[],"published":{"date-parts":[[2025,2,23]]}}}