{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T08:47:45Z","timestamp":1648802865336},"reference-count":0,"publisher":"Pakistan Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: to investigate the prevalence and severity of lower urinary tract symptoms (LUTS) among calcium channel blocker (CCB) users and its impact on patients\u2019 quality of life (QOL) Methods: This cross-sectional study was conducted among CCB-users, recruited using convenience sampling, at one hospital and 2 community pharmacies at Lahore, Pakistan during November 2017-July 2018. Urdu version of the International Prostate Symptom Score (IPSS) and EQ-5D-3L were used to assess LUTS and QOL, respectively. All data were entered and analyzed using SPSS version 22.Results: The median age of the study participants (N = 410) was 50.84, with majority of males. Around 26% of study participants were on CCB monotherapy whereas 73.7% were on CCB combinations with other antihypertensive agents. Overall prevalence of LUTS was 74.9%, with storage symptoms more common than voiding. The most common troublesome symptom was nocturia (89.5%) followed by increased daytime urinary frequency (87.1%). Median IPSS-QOL index, EQ-5D index and EQVAS score in our participants were 3, 0.621 and 60, respectively. Moreover, LUTS were significantly associated with reduced QOL (mean rank IPSS QOL-index: none-mild = 156.76 and moderate-severe = 221.85, p &lt; 0.001; median EQ 5D index; none-mild = 0.796 and moderate-severe = 0.416; mean rank EQ-VAS: none-mild = 228.51, moderate-severe = 197.78, p = 0.022).Conclusion: Around 75% of CCB-users suffer from clinically significant LUTS which is associated with significant reduction in patient\u2019s QOL. An earlier detection and management of LUTS by healthcare provider among CCB-users may and improve the overall QOL.\nContinuous...<\/jats:p>","DOI":"10.47391\/jpma.1162","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T13:37:45Z","timestamp":1612877865000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of lower urinary tract symptoms among calcium channel blocker-users and its impact on quality of life"],"prefix":"10.47391","author":[{"family":"Muhammad Salman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Amer Hayat Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Syed Azhar Syed Sulaiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jeffery David Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Junaid Habib Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Naureen Shehzadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Khalid Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2021,2,9]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"deposited":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T14:29:02Z","timestamp":1614695342000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.47391\/jpma.1162","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,9]]}}}