{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T18:28:59Z","timestamp":1648924139691},"reference-count":0,"publisher":"Pakistan Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To describe the growth pattern of children with celiac disease (CD) after introduction of a gluten-free diet (GFD).\nMethods: In this retrospective, children 2\u201316 years old with biopsy-proven CD in 2015\u20132018 were included in the study conducted at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Serial measurements of height-for-age z-score (HAZ) and weight-for-age z-score (WAZ), were recorded at 0, 4, 8, 12, and 16 months. Data on insulin-like growth hormone-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) obtained at diagnosis and during follow-up were retrieved. Clinical, demographic, and laboratory data were extracted from patients' medical files.\nResults: The median age for the patients was 8.9 years (range, 2.4\u201316 years). Males constituted 53.2%. The mean WAZ at diagnosis was -2.8\u00b11.9 and the mean HAZ was -3\u00b10.99. Trend analysis indicated a significant time effect for WAZ (p&lt;0.001) and for HAZ (p&lt;0.001). The mean IGF-1 was 133.4\u00b196.8 ng\/ml and the mean IGFBP-3 was 3174\u00b11081 ng\/ml. There was significant increase in the secretion of IGF-1 (p=0.01) and IGFBP-3 (p=0.004) during the first 8 months of a GFD.\nConclusion: The administration of a GFD for Saudi children with CD normalizes their growth parameters within 16 months of follow-up and improves the endogenous secretion of growth factors.\nKeywords: Celiac disease, growth, child, Continuous...<\/jats:p>","DOI":"10.47391\/jpma.1308","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T13:17:32Z","timestamp":1611667052000},"page":"1-17","source":"Crossref","is-referenced-by-count":0,"title":["The impact of a gluten-free diet on the growth pattern of Saudi children with celiac disease"],"prefix":"10.47391","author":[{"family":"Omar Ibrahim Saadah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2021,1,26]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"deposited":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T14:42:00Z","timestamp":1614696120000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.47391\/jpma.1308","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1,26]]}}}