{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T15:10:32Z","timestamp":1738509032548,"version":"3.35.0"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"02","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To measure biomarkers of oxidative stress and to determine hearing sensitivity by auditory brainstem response in premenopausal, perimenopausal and postmenopausal women.\nMethod: The cross-sectional, comparative study was conducted in the departments of Physiology and Audiology at the Post-Graduate Medical Institute, Lahore, and the Lahore General Hospital, Lahore, Pakistan, from November 2020 to November 2021, and comprised healthy female subjects grouped into premenopausal group 1, perimenopausal group 2 and postmenopausal group 3 as per their menstrual history. Blood samples were taken for measuring biological indicators of oxidative damage, while auditory integrity was assessed by measuring absolute latencies of waves I, III, V and interpeak latency of waves III and V at an intensity of 80dB by performing brainstem auditory evoked potential. Data was analysed using SPSS 23.\nResults: Of the 45 subjects, 15(33.3%) with mean age 41.3\u00b11.9 were in group 1, 15(33.3%) with mean age 46.7 \u00b1 3.7 years were in group 2, and 15(33.3%) with mean age 55.8\u00b12.7 years were in group 3. Significantly increased levels of thiobarbituric acid reactive substance were found in group 3 compared to groups 1 and 2 (p&lt;0.05). Regarding auditory brainstem response, a significant increase was observed in absolute latencies of waves I, III, V and interpeak latency between waves III and V in group 3 compared to the other groups (p&lt;0.05).\nConclusion: Oxidative stress had a debilitating impact on hearing sensitivity related to the menopausal status of women.\nKey Words: Menopause, Oxidative stress, Brainstem auditory evoked potential.<\/jats:p>","DOI":"10.47391\/jpma.20077","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T14:35:58Z","timestamp":1738161358000},"page":"243-248","source":"Crossref","is-referenced-by-count":0,"title":["Oxidative stress markers and brainstem auditory evoked potential in premenopausal, perimenopausal and postmenopausal females"],"prefix":"10.47391","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9549-2221","authenticated-orcid":false,"given":"Asma","family":"Ashraf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seher","family":"Naeem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madiha","family":"Akram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muniza","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2025,1,26]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/mail.jpma.org.pk\/index.php\/public_html\/article\/download\/20077\/3981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/mail.jpma.org.pk\/index.php\/public_html\/article\/download\/20077\/3981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T14:36:43Z","timestamp":1738507003000},"score":1,"resource":{"primary":{"URL":"https:\/\/mail.jpma.org.pk\/index.php\/public_html\/article\/view\/20077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,26]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2025,1,26]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.20077","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"type":"electronic","value":"0030-9982"},{"type":"print","value":"0030-9982"}],"subject":[],"published":{"date-parts":[[2025,1,26]]}}}