{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:11:40Z","timestamp":1778303500576,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"05","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To explore the prognostic value of systemic immune-inflammation in assessing patients with non-small cell lung cancer.\nMethod: The meta-analysis was conducted from May to July 2023, and comprised a comprehensive search PubMed, Excerpta Medica Database and Cochrane Library databases up to March 21, 2023, for relevant peer-reviewed articles evaluating the prognostic value of systemic immune-inflammation in patients with non-small cell lung cancer. Hazard ratio and 95% confidence interval were calculated to assess systemic immune-inflammation\u2019s relationship with overall survival and progression-free survival. Data was analysed using STATA 17.0.\nResults: Of the 135 studies initially identified, 32(23.7%) were analysed in detail, involving 12,040 patients. Increased systemic immune-inflammation was significantly associated with poor overall survival (hazard ratio: 1.31; 95% confidence interval: 1.21-1.41; p&lt;0.001) and progression-free survival (hazard ratio: 1.48; 95% confidence interval: 1.12-1.94; p&lt;0.001) in non-small cell lung cancer patients. Subgroup analysis confirmed these findings, with significant associations observed across various subgroups (country, sample size, cut-off value, survival analysis type, and TNM stage). Sensitivity analysis showed that the pooled hazard ratios remained stable, with no significant changes upon the exclusion of individual studies (p=0.75 for OS and p=0.83 for PFS). Publication bias was assessed and no significant bias was observed for either OS or PFS (Egger's test p=0.12 for OS and p=0.18 for PFS).\nConclusions: High systemic immune-inflammation was found to be a significant predictor of poor overall survival and progression-free survival in non-small cell lung cancer patients.\nKey Words: Systemic immune-inflammation index, Non-small cell lung cancer, Meta-analysis, Prognosis.<\/jats:p>","DOI":"10.47391\/jpma.20416","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:17:07Z","timestamp":1777663027000},"page":"749-757","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic role of the systemic immune-inflammation in patients with non-small cell lung cancer: a meta-analysis"],"prefix":"10.47391","volume":"76","author":[{"given":"Guomin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pucong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2026,4,20]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/20416\/4765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/20416\/4765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:44:14Z","timestamp":1778301854000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/20416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.20416","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"value":"0030-9982","type":"electronic"},{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}